2017
DOI: 10.2527/jas2017.1588
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Effects of dietary calcium fructoborate supplementation on joint comfort and flexibility and serum inflammatory markers in dogs with osteoarthritis

Abstract: Symptoms of osteoarthritis (OA) afflict approximately 20% of adult dogs in NorthAmerica. Clinical signs consistent with OA include decreased range of motion of a joint, reduced physical activity, difficulty climbing stairs or onto furniture, and a reduced ability to rise from a lying position. A safe and effective nutraceutical supplement may benefit dogs suffering from OA. Calcium fructoborate (CFB), a mimetic of a naturally occurring molecule, has previously been reported to be safe and effective in humans w… Show more

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Cited by 5 publications
(8 citation statements)
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References 87 publications
(161 reference statements)
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“…None of the three trials of calcium fructoborate nutraceuticals (ctg. 7) had any effect, whether used alone or in combination with chondroitin-glucosamine [ 58 ]. For composite nutraceuticals (ctg.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…None of the three trials of calcium fructoborate nutraceuticals (ctg. 7) had any effect, whether used alone or in combination with chondroitin-glucosamine [ 58 ]. For composite nutraceuticals (ctg.…”
Section: Resultsmentioning
confidence: 99%
“…The low quality of the hydroxycitric acid trials and the lack of efficacy of the fructoborate trials did not allow one to definitively conclude on the use of these products. However, for both types of products, all trials were obtained from the same article [ 39 , 58 ], which could potentially bias our conclusions. Regarding composite nutraceuticals (ctg.…”
Section: Discussionmentioning
confidence: 99%
“…13 Common ingredients incorporated into therapeutic diets formulated for joint health include omega-3 fatty acids, GLM, glucosamine, and chondroitin sulfate. Results of several studies 1,3,4,10,[18][19][20][21]23 support that these ingredients are beneficial in the management of osteoarthritis, particularly in dogs since research involving cats is more limited (Table 1). The combination of chondroitin sulfate, glucosamine, and omega-3 fatty acids has also been shown to improve the joint status of search-and-rescue dogs as assessed by subjective means.…”
Section: Osteoarthritis Management With Nsaids and Multimodal Therapymentioning
confidence: 99%
“…Furthermore, lack of sensitivity and specificity is limiting the diagnostic competence of the conventional serum inflammatory markers including tumor necrosis factor-α (TNF-α), an important proinflammatory cytokine in the innate immune response; C-reactive protein (CRP), an acute-phase protein that plays an important physiological role in complement system activation; and the erythrocytes sedimentation rate (ESR), a well-validated and inexpensive test for the evaluation of inflammation. 5-7…”
Section: Introductionmentioning
confidence: 99%
“…13,18-20 We also endeavored to conduct the correlation between these 2 proteins with OA progression and with a set of conventional OA-related inflammatory markers, including TNF-α, CRP, and ESR. 5-7…”
Section: Introductionmentioning
confidence: 99%