Effects of Dietary Composition on Energy Expenditure During Weight-Loss Maintenance

Ebbeling, Cara B.; Swain, JaBaris D.; Feldman, Henry A.; Wong, William W.; Hachey, David L.; Garcia-Lago, Erica; Ludwig, David S.

doi:10.1001/jama.2012.6607

Cited by 347 publications

(284 citation statements)

References 50 publications

(45 reference statements)

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“…The proportion of calories derived from nutrients for the KD, which is similar to other studies (2,12,16,18), and control diet is described in Table 1. In addition, 8-wk-old male C57BL/6J mice were fed a KD or a normal diet (D12450B; Research Diets) for 1 wk.…”

Section: Animalssupporting

confidence: 68%

“…In patients with the metabolic syndrome, increased MCP-1 is associated with macrophage infiltration in fat tissue and a proinflammatory state (8). Recently, a short-term verylow-carbohydrate diet in overweight and obese humans resulted in increased concentrations of the inflammatory marker C-reactive protein (12), which is associated with an increased risk for the metabolic syndrome (18).…”

Section: Discussionmentioning

confidence: 99%

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Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice

Ellenbroek

Dijck

Töns

et al. 2014

American Journal of Physiology-Endocrinology and Metabolism

126

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Ellenbroek JH, van Dijck L, Töns HA, Rabelink TJ, Carlotti F, Ballieux BE, de Koning EJ. Long-term ketogenic diet causes glucose intolerance and reduced ␤-and ␣-cell mass but no weight loss in mice. Am J Physiol Endocrinol Metab 306: E552-E558, 2014. First published January 7, 2014 doi:10.1152/ajpendo.00453.2013.-High-fat, low-carbohydrate ketogenic diets (KD) are used for weight loss and for treatment of refractory epilepsy. Recently, short-time studies in rodents have shown that, besides their beneficial effect on body weight, KD lead to glucose intolerance and insulin resistance. However, the long-term effects on pancreatic endocrine cells are unknown. In this study we investigate the effects of long-term KD on glucose tolerance and ␤-and ␣-cell mass in mice. Despite an initial weight loss, KD did not result in weight loss after 22 wk. Plasma markers associated with dyslipidemia and inflammation (cholesterol, triglycerides, leptin, monocyte chemotactic protein-1, IL-1␤, and IL-6) were increased, and KD-fed mice showed signs of hepatic steatosis after 22 wk of diet. Long-term KD resulted in glucose intolerance that was associated with insufficient insulin secretion from ␤-cells. After 22 wk, insulin-stimulated glucose uptake was reduced. A reduction in ␤-cell mass was observed in KD-fed mice together with an increased number of smaller islets. Also ␣-cell mass was markedly decreased, resulting in a lower ␣-to ␤-cell ratio. Our data show that long-term KD causes dyslipidemia, a proinflammatory state, signs of hepatic steatosis, glucose intolerance, and a reduction in ␤-and ␣-cell mass, but no weight loss. This indicates that long-term high-fat, lowcarbohydrate KD lead to features that are also associated with the metabolic syndrome and an increased risk for type 2 diabetes in humans. pancreatic islet; ketogenic diet; glucose intolerance; ␤-cell; ␣-cell

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Section: Animalssupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice

Ellenbroek

Dijck

Töns

et al. 2014

American Journal of Physiology-Endocrinology and Metabolism

126

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“…In addition, DASH can be the focus of treatment because recent evidence shows (1) the ready adaptability and enhanced metabolic and CVD risk benefits with DASH plus additional protein [30], (2) modest weight loss through exercise and DASH with reduced energy intake improves insulin sensitivity [31], (3) the association of refined carbohydrates, sugared beverages, and processed foods (i.e., high glycemic load)-and not all higher fat foods-with weight gain, while many foods featured in DASH (e.g., fruits and vegetables, whole grains, nuts) are associated with weight stabilization or loss [32,33], and (4) traditional reduced calorie, lower fat, and higher carbohydrate weight loss diets can result in reduced resting energy expenditure (REE) and total energy expenditure ( TEE), setting the stage for weight regain [7,11]. Studies indicate that the amount of initial weight loss often is not affected by the macronutrient content of the dietary plan, but a higher protein diet may limit weight regain [7,8,11,34,35]. However, the types of foods and meal patterns for DASH are quite PRACTICE AND PUBLIC HEALTH POLICIES different from how most US adults eat [36], raising issues of feasibility and adherence.…”

Section: Policymentioning

confidence: 99%

Developing a new treatment paradigm for disease prevention and healthy aging

Winett

Davy

Marinik

et al. 2013

Behav. Med. Pract. Policy Res.

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An increasingly prevalent pattern of risk factors has emerged in middle-aged and older adults that includes the presence of type 2 diabetes or prediabetes, overweight or obese weight status with central obesity and very high body fat, low cardiorespiratory fitness (CRF), low strength, and a low lean-body-mass-to-body-fat ratio. Traditionally, these problems have been approached with a low-fat and low-calorie diet and with lower to moderate intensity activity such as walking. While the treatment has some clear benefits, this approach may no longer be optimal because it does not reflect more recent findings from nutrition and exercise sciences. Specifically, these fields have gained a greater understanding of the metabolic and functional importance of focusing on reducing body fat and central obesity while maintaining or even increasing lean body mass, a quality weight loss, and how to efficiently and effectively increase CRF and strength. Evidence is presented for shifting the treatment paradigm for disease prevention and healthy aging to include the DASH nutrition pattern but with additional protein, higher intensity, brief aerobic training, effortbased, brief resistance training, and structured physical activity. Recent interventions based on social cognitive theory for initiating and then maintaining health behavior changes show the feasibility and efficacy of the approach we are advocating especially within a multiple health behavior change format and the potential for translating the new treatment paradigm into practice. KEYWORDSDiabetes, Quality weight loss, Treatment paradigm, Multiple health behaviors IMPORTANCE OF THE PROBLEM, USUAL TREATMENT, CHANGING THE TREATMENT PARADIGM A pressing public health problem is the high prevalence of engagement in multiple, poor health behaviors, creating patterns of high risk for morbidity and mortality and contributing to considerable individual and societal financial burden [1,2]. One pattern that is becoming increasingly prevalent is the combination of prediabetes, overweight or obese weight status, central obesity (increased visceral adipose tissue), and low cardiorespiratory fitness (CRF) with gradual loss of lean body mass and strength [3], which further increases the risks for type 2 diabetes (T2D), cardiovascular diseases, and some cancers, disabilities, and premature death [4]. The prevalence of T2D, based on fasting glucose or hemoglobin A1c levels in adults, aged 45-64 years old, is~14 %, and the prevalence of prediabetes for adults >20 years old is~35 % [5]. For adults over 65 years old, the prevalence of T2D is 27 % and the prevalence of prediabetes is~50 % [5]. Overweight, not just obesity weight status, is often comorbid for central obesity (waist circumference (WC) ≥102 cm for men and ≥88 cm for women) [3], which is associated with increased risk of T2D, especially for women [6]. Overweight individuals with large WC's, though at high risk, are often not identified for interventions [6,7]. The normal agerelated loss of lean body mass beginning in m...

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“…While the role of dietary fats as an independent risk factor in obesity is still debated, it is largely recognized that they have a major contribution to this metabolic condition by increasing the energy density of food and thus facilitating excessive calory intake [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Maternal Knowledge, Attitudes and Practices Regarding Dietary Fats

Nădășan

Andreea

Tarcea

et al. 2016

Acta Medica Marisiensis

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Objective: The purpose of the study was to assess the knowledge, attitudes, and behavior regarding dietary fats among mothers in Romania. Material and methods: A sample of 305 mothers from Romania were included in a cross-sectional observational study. The online questionnaire addressed their knowledge, attitudes, and practices regarding the dietary fats used in their children's diet. The frequencies and proportions of the collected variables were calculated based on respondents' answers. Results: While almost all the respondents (94.8%) believed that mothers are supposed to know the difference between saturated and unsaturated fats, only less than half of them (39.7%) stated that they know the difference. As far as the types of margarine, although more than half of the respondents (64.7%) believed that mothers should be able to discriminate between the hydrogenated and interesterified margarine, only 11.5% claimed that they are able to discern between them. The actual ability to identify foods rich in saturated fats varied in a great degree from item to item. More common dietary fats such as sunflower oil, corn oil, and lard, were more frequently identified than less common dietary fats such as coconut oil and palm oil. Only 16.4% of the mothers were able to correctly differentiate hydrogenated from interesterified margarine. The most frequently used spreadable fat used in the children's diet was butter and the most frequently used cooking fats were sunflower oil, olive oil, and butter. Conclusion: The results of this study might be informative in the development of maternal nutrition education programs.

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Effects of Dietary Composition on Energy Expenditure During Weight-Loss Maintenance

Cited by 347 publications

References 50 publications

Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice

Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice

Developing a new treatment paradigm for disease prevention and healthy aging

Maternal Knowledge, Attitudes and Practices Regarding Dietary Fats

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