Effects of dietary conjugated linoleic acid on some aspecific immune parameters and acute phase protein in weaned piglets

Corino, C.; Bontempo, V.; Sciannimanico, D.

doi:10.4141/a01-041

Cited by 24 publications

(13 citation statements)

References 8 publications

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“…Sugano et al (1998) reported that CLA increased the production of non-specific immunoglobulins such as IgA, IgG, and IgM and decreased IgE concentration in rats. Corino et al (2002) also observed an increase in serum IgG of piglets Effects of dietary CLA supplementation on weaned pigs 49 due to dietary CLA supplementation. These studies indicated that CLA had positive modulatory impact on the humoral immune response.…”

Section: Discussionmentioning

confidence: 73%

Effects of dietary conjugated linoleic acid supplementation on performance and immune function of weaned pigs

Lai

Yin²,

Li³

et al. 2005

Archives of Animal Nutrition

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Two experiments were conducted to evaluate the effect of dietary conjugated linoleic acid (CLA) on performance and immune responses of weaned pigs. In Exp. I, 72 crossbred pigs weaned at 19 to 23 days of age and weighing 7.20 +/- 0.11 kg were randomly allotted to four diets supplemented with CLA at 0, 1, 2 or 3%. On day 14, pigs were injected with ovalbumin (1mg per kg BW) and blood samples were collected on day 7 and 14 after injection to test the specific OVA antibody. In Exp. II, 36 crossbred pigs weaned at 26 to 30 days of age and weighing 8.12 +/- 0.14 kg were randomly divided into two diets containing either 0 or 2% CLA. On day 14 and 28, blood samples were obtained to determine the lymphocyte proliferation and PGE2 levels in both trials, and CD4+, CD8+ T cells subsets and interleukin-1beta production were tested in Exp. II. In Exp. I both average daily gain and average daily feed intake of weaned pigs were improved quadratically and feed efficiency was increased linearly by CLA supplementation. Lymphocyte proliferation response to concanavalin A was increased quadratically as dietary CLA concentration increased on day 14 and 28. Ovalbumin antibody production levels were increased linearly on day 7 after injection of ovalbumin and increased quadratically on day 14 after injection, which follows the increased CLA levels, whereas CLA reduced linearly the production of prostaglandin E2 (PGE2). The results of Exp. II indicated that CLA improved performance, lymphocyte proliferation, and increased the CD8+ lymphocyte population, while reduced the production of PGE2 and interleukin-lbeta (IL- 1beta). These results suggest that the supplementation of CLA enhanced lymphocyte proliferation function, possibly by regulating the PGE2 production, and improved growth performance of pigs. Further studies are needed to determine the mechanism of CLA-induced inhibition of IL-1beta production.

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Section: Discussionmentioning

confidence: 73%

Effects of dietary conjugated linoleic acid supplementation on performance and immune function of weaned pigs

Lai

Yin²,

Li³

et al. 2005

Archives of Animal Nutrition

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“…An increase in the level of lysozyme in sows and piglets receiving CLA was another observed physiological eff ect of this fatty acid. Lysozyme, which is present in secretions and leucocytes, is very effi cient against gram-positive bacteria (Corino et al, 2002). Weber et al (2001) reported that a supplement of CLA increased the level of serum antibodies against bacteria of the species Mycoplasma hyopnemoniae.…”

Section: Resultsmentioning

confidence: 99%

Effect of feeding sows on rations enriched with conjugated linoleic acid (CLA) and the growth capacity and survival of their piglets

Hadaš¹,

Čechová²,

Nevrkla³

2013

Acta Univ. Agric. Silvic. Mendelianae Brun.

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The evaluation of the effect of supplements of conjugated linoleic acid (CLA) given to pregnant and lactating sows on the phenotypic manifestation of their reproductive performance and on the birth and weaning weight of piglets was performed under conditions of a commercial herd of pigs. The experiment involved altogether 40 hybrid sows divided into two equal groups, i.e. Controls with 20 sows and Experimental Group with also 20 sows. Experimental Group received within the time interval from the 108th day of pregnancy to the 28th day after the parturition a supplement of 2 % of CLA. In individual litters the following performance parameters were recorded: number of all newborn piglets, number of piglets born alive, number of stillbirths, number of weaned piglets and individual weights of newborn piglets and weaned piglets. Obtained results concerning numbers of all newborn piglets in Controls and Experimental Group (i.e. 12.20 ± 2.09 and 11.85 ±2.58, respectively) indicate that supplementing of the feeding ration with CLA in the last stage of pregnancy does not influence the size of litter. In Controls, numbers of piglets born alive were higher by 0.4 animals per litter; this difference, however, was statistically insignificant. Also the weights of newborn and weaned piglets were not influenced by the supplement of CLA. Statistically significant differences (P ≤ 0.01) were found out between Controls and Experimental Group in numbers of weaned piglets, viz. 9.75 ± 1.68 vs. 8.35 ± 1.39, respectively, and between corresponding losses until weaning, viz. 0.95± 1.39 vs. 2.60 ± 1.93 in Controls and Experimental Group, respectively (P ≤ 0.01).

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“…In contrast, Bontempo et al [ 24 ] and Corino et al [ 13 ] reported that 0.5% CLA supplementation to sows during lactation had no effect on NEFA levels. Corino et al [ 18 ] also observed no difference in NEFA concentration with increasing amount of CLA, whereas triacylglycerol levels markedly decreased in rabbits. On the other hand, Ostrowska et al [ 40 ] found that dietary CLA treatment significantly increased plasma NEFA and triacylglycerol levels in pigs, with no effect on plasma glucose and insulin levels.…”

Section: Discussionmentioning

confidence: 98%

“…As these results are contradictory, further research is needed to elucidate the effects of dietary CLA on milk yield and body weight changes in lactating sows. Regarding immunity in piglets, Corino et al [ 13 , 18 ] found that increasing levels of CLA fed to sows or weaned piglets markedly increased the immunoglobulin G (IgG) concentrations of piglets during suckling and post-weaning. Therefore, transfer of CLA from sows to milk could reduce mortality in piglets by increasing immunity.…”

Section: Introductionmentioning

confidence: 99%

Dietary Conjugated Linoleic Acid (CLA) increases milk yield without losing body weight in lactating sows

et al. 2014

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This study was conducted to evaluate the effects of dietary conjugated linoleic acid (CLA) on the performance of lactating sows and piglets as well as the immunity of piglets suckling from sows fed CLA. Eighteen multiparous Duroc sows with an average body weight (BW) of 232.0 ± 6.38 kg were randomly selected and assigned to two dietary treatments (n = 9 for each treatment), control (no CLA addition) and 1% CLA supplementation. For the control diet, CLA was replaced with soybean oil. Experimental diets were fed to sows during a 28-day lactation period. Litter size for each sow was standardized to nine piglets by cross-fostering within 24 hours after birth. Sow milk and blood samples were taken from sows and piglets after 21 and 27 days of lactation, respectively. Loss of BW was significantly (p < 0.05) higher in sows fed control diet compared to sows fed CLA diet. Piglet weights at weaning and weight gain during suckling were significantly (p < 0.05) higher in sows fed CLA compared to sows fed control diet. Serum non-esterified fatty acid (NEFA) and urea nitrogen concentrations were significantly (p < 0.05) lower in sows fed CLA than in sows fed soybean oil. IgG concentrations of the groups supplemented with CLA increased by 49% in sow serum (p < 0.0001), 23% in milk (p < 0.05), and 35% in piglet serum (p < 0.05) compared with the control group. Sows fed CLA showed an increase of 10% in milk yield compared with sows fed soybean oil (p < 0.05), even though there was no difference in daily feed intake between the treatments. Milk fat content was significantly (p < 0.05) lower in sows fed CLA than in sows fed soybean oil. Solid-not-fat yield was significantly (p < 0.05) higher in sows supplemented with CLA than in sows fed control diet and also protein-to-fat ratio in milk was significantly (p < 0.05) higher in sows fed CLA compared with the control group. The results show that CLA supplementation to sows increased milk yield without losing BW during lactation, whereas soybean oil supplementation resulted in severe BW loss.

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Effects of dietary conjugated linoleic acid on some aspecific immune parameters and acute phase protein in weaned piglets

Cited by 24 publications

References 8 publications

Effects of dietary conjugated linoleic acid supplementation on performance and immune function of weaned pigs

Effects of dietary conjugated linoleic acid supplementation on performance and immune function of weaned pigs

Effect of feeding sows on rations enriched with conjugated linoleic acid (CLA) and the growth capacity and survival of their piglets

Dietary Conjugated Linoleic Acid (CLA) increases milk yield without losing body weight in lactating sows

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