Effects of Dietary D‐Psicose on Diurnal Variation in Plasma Glucose and Insulin Concentrations of Rats

Matsuo, Tatsuhiro; Shirai, Yoko; Izumori, Ken

doi:10.1096/fasebj.20.4.a594-c

Cited by 10 publications

(11 citation statements)

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“…In agreement with previous studies, ,,, body weight and food intake were significantly lower in rats fed the d -psicose diet compared to rats fed the control diet in experiment 2. It therefore appears that although d -psicose provides no calories, rats fed the 3% d -psicose diet did not increase food intake to compensate for the displaced energy, resulting in reduced body weight.…”

Section: Discussionsupporting

confidence: 93%

“…17−23 Matsuo et al also found that when rats were fed diets with D-psicose, compared to sucrose-or fructose-based diet, D-psicose reduced fat content in the entire carcass and abdominal adipose tissue weight of rats. 18 Similarly, Hossain confirmed reduced lipid accumulation in the liver of type 2 diabetic rats given D-psicose in their drinking water. 16 The hypolipidemic action of D-psicose was also observed in animals fed a mixture of D-psicose and other sugars in their diet.…”

Section: D-mentioning

confidence: 80%

“…20 Hepatic CPT, an enzyme that catalyzes a rate-limiting step in fatty acid oxidation, 38 was marginally elevated by D-psicose during the dark period (p = 0.06 at 9:00 p.m.) (Figure 4). Given that D-psicose reduces liver levels of triglyceride 13,16 and adipose tissue weight, [15][16][17][18]22,23 these results probably imply that the combined effects of lowered fatty acid synthesis and enhanced fatty acid oxidation in the liver at least partly contribute to decreased liver triglyceride and adipose tissue weight in rats fed the D-psicose diet. This hypothesis may also support the results observed in 24 h energy expenditure; D-psicose enhanced energy expenditure in the light period and fat oxidation during the dark period (Figure 9).…”

Section: ■ Discussionmentioning

confidence: 94%

“…It has also been reported that the hypoglycemic action of d -psicose may be derived from decreased absorption of sugars, , enhanced insulin sensitivity, − and altered hepatic glucose metabolism via the translocation of glucokinase (GK) − Matsuo et al also found that when rats were fed diets with d -psicose, compared to sucrose- or fructose-based diet, d -psicose reduced fat content in the entire carcass and abdominal adipose tissue weight of rats . Similarly, Hossain confirmed reduced lipid accumulation in the liver of type 2 diabetic rats given d -psicose in their drinking water .…”

Section: Introductionmentioning

confidence: 89%

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d-Psicose, an Epimer of d-Fructose, Favorably Alters Lipid Metabolism in Sprague–Dawley Rats

Nagata

Kanasaki

Tamaru

et al. 2015

J. Agric. Food Chem.

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D-Psicose, a C3 epimer of D-fructose, is known to lower body weight and adipose tissue weight and affect lipid metabolism. The precise mechanism remains unknown. It has been reported that D-psicose has a short half-life and is not metabolized in the body. To determine how D-psicose modifies lipid metabolism, rats were fed diets with or without 3% D-psicose for 4 weeks. Rats were decapitated without fasting every 6 h over a period of 24 h. Changes in serum and liver lipid levels, liver enzyme activity, and gene expression were quantified in experiment 1. Rats fed D-psicose had significantly lower serum insulin and leptin levels. Liver enzyme activities involved in lipogenesis were significantly lowered by the D-psicose diet, whereas gene expression of a transcriptional modulator of fatty acid oxidation was enhanced. In experiment 2, feeding the D-psicose diet gave significantly lower body weight (389 ± 3 vs 426 ± 6 g, p < 0.05) and food intake (23.8 ± 0.2 vs 25.7 ± 0.4 g/day, p < 0.05) compared to the control diet. Rats fed the D-psicose diet gave significantly higher energy expenditure in the light period and fat oxidation in the dark period compared to rats fed the control diet, whereas carbohydrate oxidation was lower. In summary, these results indicate that the D-psicose diet decreases lipogenesis, increases fatty acid oxidation, and enhances 24 h energy expenditure, leading to d-psicose's potential for weight management.

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Section: Discussionsupporting

confidence: 93%

Section: D-mentioning

confidence: 80%

Section: ■ Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 89%

See 2 more Smart Citations

d-Psicose, an Epimer of d-Fructose, Favorably Alters Lipid Metabolism in Sprague–Dawley Rats

Nagata

Kanasaki

Tamaru

et al. 2015

J. Agric. Food Chem.

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“…4 Moreover, it also improves the gelling properties of food, increases flavor pleasantness, and reduces oxidation in the Maillard reaction. 5−7 Additionally, D-psicose has many advantageous physiological properties, including the ability to reduce the accumulation of intra-abdominal fat, 8,9 scavenge reactive oxygen species (ROS), 10 suppress hepatic lipase activity, 11 reduce postprandial glycemic elevation, 12,13 improve the metabolism of blood lipids, 14 protect the nervous system, 15 increase insulin resistance, 16,17 and treat atherosclerotic diseases. 18 D-Psicose is scarce in nature and difficult to chemically synthesize.…”

Section: ■ Introductionmentioning

confidence: 99%

Improving the Thermostability and Catalytic Efficiency of the d-Psicose 3-Epimerase from Clostridium bolteae ATCC BAA-613 Using Site-Directed Mutagenesis

Zhang¹,

Jia²,

Yu³

et al. 2016

J. Agric. Food Chem.

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d-Psicose is a highly valuable rare sugar because of its excellent physiological properties and commercial potential. d-Psicose 3-epimerase (DPEase) is the key enzyme catalyzing the isomerization of d-fructose to d-psicose. However, the poor thermostability and low catalytic efficiency are serious constraints on industrial application. To address these issues, site-directed mutagenesis of Tyr68 and Gly109 of the Clostridium bolteae DPEase was performed. Compared with the wild-type enzyme, the Y68I variant displayed the highest substrate-binding affinity and catalytic efficiency, and the G109P variant showed the highest thermostability. Furthermore, the double-site Y68I/G109P variant was generated and exhibited excellent enzyme characteristics. The Km value decreased by 17.9%; the kcat/Km increased by 1.2-fold; the t1/2 increased from 156 to 260 min; and the melting temperature (Tm) increased by 2.4 °C. Moreover, Co(2+) enhanced the thermostability significantly, including the t1/2 and Tm values. All of these indicated that the Y68I/G109P variant would be appropriate for the industrial production of d-psicose.

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Synthesis of and NMR studies on the four diastereomeric 1-deoxy-d-ketohexoses

Jones¹,

Jenkinson²,

Soengas³

et al. 2007

Tetrahedron: Asymmetry

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Effects of Dietary D‐Psicose on Diurnal Variation in Plasma Glucose and Insulin Concentrations of Rats

Cited by 10 publications

References 0 publications

d-Psicose, an Epimer of d-Fructose, Favorably Alters Lipid Metabolism in Sprague–Dawley Rats

d-Psicose, an Epimer of d-Fructose, Favorably Alters Lipid Metabolism in Sprague–Dawley Rats

Improving the Thermostability and Catalytic Efficiency of the d-Psicose 3-Epimerase from Clostridium bolteae ATCC BAA-613 Using Site-Directed Mutagenesis

Synthesis of and NMR studies on the four diastereomeric 1-deoxy-d-ketohexoses

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