Effects of dietary ethanol, acetaldehyde, 2-propanol and acetone on the variation of several enzyme activities involved in alcohol metabolism of Drosophila melanogaster adults

Barbancho, M.

doi:10.1016/0965-1748(92)90064-l

Cited by 13 publications

(5 citation statements)

References 34 publications

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“…5). In accordance with the studies of HEINSTRA et al (1983), GEER et al (1985, ANDER-SON and BARNETT (1991) and BARBANCHO (1992) certain elements of our results also indicate that different genetic factors are responsible for the utilization and detoxification of ethanol in the larvae. In the analysis of the genetic background, we found that at low concentrations, when utilization is assumed to be the crucial process, differences in larval survival were larger between the two Adh genotypes than between the two lines ( Fig.…”

Section: Discussionsupporting

confidence: 93%

Differences in the Effect of Ethanol on Fertility and Viability Components Among Laboratory Strains of Drosophila Melanogaster

Bokor

Pecsenye

2004

Hereditas

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We studied the effect of ethanol on several fitness components in six Drosophila melanogaster strains. Mating success, fecundity, egg-to-larva, egg-to-pupa and egg-to-adult survival and the number of emerging adults were estimated in a single series of experiments. The strains either had different combinations of genetic background and Adh genotypes with identical OdhF genotype or different Adh-Odh two-locus genotypes with similar genetic background. Ethanol had the greatest effect on mating success and fecundity, while its influence was lower on survival. When the experimental conditions were contrasted to the natural environment of the flies the most significant results were the ones related to fecundity and larval survival. Ethanol had the highest selective effect on fecundity. The genetic factors contributed substantially to the variation in the fertility and viability components. The Adh locus hardly influenced mating success while it had a sizable effect on fecundity and on all survival components. The influence of Adh on fecundity greatly depended on the other genetic factors. Genetic background had the largest influence on the different survival components. The influence of the Odh locus was mostly observed through the Adh-Odh interaction.

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Section: Discussionsupporting

confidence: 93%

Differences in the Effect of Ethanol on Fertility and Viability Components Among Laboratory Strains of Drosophila Melanogaster

Bokor

Pecsenye

2004

Hereditas

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“…Through the use of cyanamide, Barbancho and co-workers (Barbancho, 1992;Martinez-Leal and Barbancho, 1992) found that elimination of all but 15% of the adult wild-type ALDH activity greatly increased the sensitivity of adults to environmental ethanol. This indicates that in adults the second step of acetaldehyde oxidation is mediated mainly by Drosophila ALDH.…”

Section: The Metabolic Fate Of Ethanolmentioning

confidence: 99%

The biological basis of ethanol tolerance in Drosophila

Geer

Heinstra

McKechnie

1993

Comparative Biochemistry and Physiology Part B: Comparative Bio

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“…In Drosophila melanogaster , a species which is tolerant to ethanol and feeds on fermenting fruit, 90% of ingested alcohols is degraded by the ADH pathway ( Heinstra et al., 1987). Although adult flies are able to select feeding sites that are compatible with their tolerance to ethanol, larvae adapt to alcohol contents of their diet by altering their enzymatic activity ( Barbancho , 1992).…”

Section: Introductionmentioning

confidence: 99%

Alcohol dehydrogenase allele frequencies in Bactrocera oleae (Dipt., Tephritidae): effect of ethanol addition in larval diet

Κωνσταντοπούλου

Raptopoulos

2003

J Applied Entomology

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The effect of ethanol in larval medium on Bactrocera oleae larvae was examined at four concentrations. Ethanol exerted a differential effect on the three alcohol dehydrogenase allele frequencies. While originally being at equilibrium under laboratory conditions, after three generations of larval development in a diet containing ethanol at 1% concentration, Adh-F allele frequency increased, that of Adh-I dropped significantly and the frequency of Adh-S remained unaltered. Adh-S allele seems to be adapted in nature where only minor quantities of alcohol are present in the insectsÕ natural host, while Adh-I is best adapted in the alcohol-free laboratory culture medium. The frequency of Adh-F allele remains unaltered when feral populations are introduced in the laboratory.

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Effects of dietary ethanol, acetaldehyde, 2-propanol and acetone on the variation of several enzyme activities involved in alcohol metabolism of Drosophila melanogaster adults

Cited by 13 publications

References 34 publications

Differences in the Effect of Ethanol on Fertility and Viability Components Among Laboratory Strains of Drosophila Melanogaster

Differences in the Effect of Ethanol on Fertility and Viability Components Among Laboratory Strains of Drosophila Melanogaster

The biological basis of ethanol tolerance in Drosophila

Alcohol dehydrogenase allele frequencies in Bactrocera oleae (Dipt., Tephritidae): effect of ethanol addition in larval diet

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