Effects of dietary factors on oxidation of low-density lipoprotein particles

Lapointe, Annie; Couillard, Charles; Lemieux, Simone

doi:10.1016/j.jnutbio.2006.01.001

Cited by 142 publications

(103 citation statements)

References 158 publications

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“…Coronary heart disease was also associated with a higher ox-LDL/LDLcholesterol ratio, which is consistent with previous studies [2][3][4]. Women with cancer also had a higher ox-LDL/LDL-cholesterol ratio than women without cancer in this study, which is consistent with a previous study that showed elevated ox-LDL in women with breast or ovarian cancer [30].A healthy food pattern, such as the Mediterranean style diet, has been associated with decreased oxidizability of LDL particles [31][32][33][34] …”

supporting

confidence: 92%

“…A healthy food pattern, such as the Mediterranean style diet, has been associated with decreased oxidizability of LDL particles [31][32][33][34] …”

Section: Discussionmentioning

confidence: 99%

“…A healthy food pattern, such as the Mediterranean style diet, has been associated with decreased oxidizability of LDL particles [31][32][33][34], reduced inflammation [35][36][37], reduced risk of cardiovascular disease [31], and lower mortality [38]. Dietary factors have been shown to modulate ox-LDL, but inconsistent results have been shown for antioxidant supplements and ox-LDL [33].…”

Section: Discussionmentioning

confidence: 99%

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Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling women

et al. 2008

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Objective-The objective of this study was to determine whether total serum carotenoids, alphatocopherol, selenium, and obesity were independently associated with oxidized low-density lipoproteins (ox-LDL) in moderately to severe disabled older women living in the community.Methods-Serum ox-LDL, carotenoids, alpha-tocopherol, and selenium were measured in a population-based sample of 543 moderately to severely disabled women, aged 65 and older, in the Women's Health and Aging Study I in Baltimore, Maryland.Results-Total serum carotenoids, smoking, overweight (BMI 25-29.9 kg/m 2 ), and obesity (BMI≥30 mg/kg 2 ) were significantly associated with ox-LDL/LDL-cholesterol ratio after adjusting for age, C-reactive protein, and chronic diseases. Alpha-tocopherol and selenium were not significantly associated with ox-LDL/LDL-cholesterol ratio.Conclusions-Older women who are overweight or obese or who have low total serum carotenoids are more likely to have higher lipoprotein oxidation. Weight reduction in overweight/obese women and increased intake of carotenoid-rich foods may potentially reduce lipoprotein oxidation. Keywordsbody mass index; carotenoids; low-density lipoproteins; obesity; oxidative stress Oxidation of low-density lipoproteins is considered a key factor in the pathogenesis of atherosclerosis and cardiovascular disease [1]. Oxidized low-density lipoproteins (ox-LDL) are taken up by scavenger receptors on macrophages and contribute to the formation of foam cells and atherosclerotic lesions [1]. Elevated circulating ox-LDL are associated with more severe atherosclerotic lesions [2], and high circulating levels of ox-LDL have been shown to be independently predictive of subclinical atherosclerosis [3] and acute coronary heart disease [4].Obesity is a strong risk factor for cardiovascular disease [5]. Both abdominal obesity and general obesity (body mass index >30 kg/m 2 ) were shown to be independently associated with circulating ox-LDL among men and women, aged in Spain [6]. Among subjects with LDL is a large particle that contains one apoB molecule and a large number of triacylglycerol, free cholesterol, cholesterol ester, and phospholipid molecules [9]. LDL contains carotenes and xanthophylls, the two major classes of carotenoids in humans, and carotenoids protect LDL against oxidation [10]. The carotenoid content of LDL has been shown to be strongly correlated with serum carotenoid concentrations [11,12].Although carotenoids are known to protect LDL particles from oxidation, the relationship between total serum carotenoid concentrations and circulating ox-LDL has not been well characterized in humans. We hypothesized that both obesity and low total serum carotenoids were associated with elevated circulating ox-LDL in older adults. To address this hypothesis, we assessed serum ox-LDL among older women living in the community who participated in the Women's Health and Aging Study I. Subjects and MethodsSubjects in this study were women, aged 65 and older, who participated in the Women's Health and...

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supporting

confidence: 92%

“…A healthy food pattern, such as the Mediterranean style diet, has been associated with decreased oxidizability of LDL particles [31][32][33][34] …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling women

et al. 2008

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“…Supplementation with antioxidant vitamins increased arterial elasticity and reduced blood pressure in patients with multiple cardiovascular risk factors [19], slowed down the atherosclerotic progression [20], and showed a beneficial effect on endothelial flow [21]. In a cohort analysis, antioxidant supplementation decreased total cancer incidence and total mortality in men [22].…”

Section: Discussionmentioning

confidence: 99%

Role of antioxidant vitamins administration on the oxidative stress

Tomoeda¹,

Kubo

Yoshizawa

et al. 2013

Open Medicine

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AbstractThe health-promoting effects of antioxidant vitamins C and E supplementation are unclear. This study investigated the effects of vitamins C and E on the activities of reactive oxygen species (ROS)-scavenging enzymes and protein and lipid peroxidation statuses under resting and exercise-induced conditions. Thirteen healthy, previously untrained males (age 20–21 years) participated in this study. Seven subjects performed physical exercise using a cycle ergometer, and six performed a 6-min walk test (6MWT) prior to vitamin administration and after 1-week oral administration of vitamin C (1000 mg/day) and vitamin E (300 IU/day). Venous blood samples were collected before and after exercise. Plasma vitamin C concentration, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity, and protein carbonyl and thiobarbituric acid-reactive substance (TBARS) contents were measured. Antioxidant supplementation increased vitamin C concentration by 34% (p<0.05), decreased SOD activity by 17% (p<0.05), increased GPx activity by 13% (p<0.05), and increased the GPx/SOD activity ratio by 37% (p<0.05). Protein carbonyl and TBARS contents were unaffected. Antioxidant vitamins effectively increase the plasma GPx/SOD activity ratio, but fail to reduce protein carbonyl levels induced by exercise.

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“…The Panel considers that both TBARS and MDA, when used alone, are not reliable markers of lipid peroxidation (Griffiths et al, 2002;Knasmuller et al, 2008;Lykkesfeldt, 2007). The Panel also considers that no evidence has been provided to establish that the oxidation lag time of LDL particles ex vivo or that autoantibodies against oxidised LDL particles predict the resistance of LDL particles to peroxidation in vivo (Griffiths et al, 2002;Lapointe et al, 2006;Verhoye and Langlois, 2009).…”

Section: Maintenance Of Normal Cardiac Function (Id 1767 3595 4509)mentioning

confidence: 99%

Scientific Opinion Part I on the substantiation of health claims related to various food(s)/food constituent(s) not supported by pertinent human data (ID 411, 559, 1174, 1184, 1197, 1380, 1409, 1656, 1667, 1670, 1763, 1767, 1806, 1884, 1908, 1997, 2141, 2

Products¹

2011

EFSA Journal

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SUMMARYFollowing a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924. This opinion addresses the scientific substantiation of health claims in relation to various food(s)/food constituent(s) not supported by pertinent human data. The scientific substantiation is based on the information provided by the Member States in the consolidated list of Article 13 health claims and references that EFSA has received from Member States or directly from stakeholders.The references provided in relation to the claims evaluated in this opinion included studies which assessed the effects of food(s)/food constituent(s) other than the food(s)/food constituent(s) which are the subject of the claims, and/or investigated health outcomes unrelated to the claimed effects. No 1 On request from the European Commission, Question

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Effects of dietary factors on oxidation of low-density lipoprotein particles

Cited by 142 publications

References 158 publications

Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling women

Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling women

Role of antioxidant vitamins administration on the oxidative stress

Scientific Opinion Part I on the substantiation of health claims related to various food(s)/food constituent(s) not supported by pertinent human data (ID 411, 559, 1174, 1184, 1197, 1380, 1409, 1656, 1667, 1670, 1763, 1767, 1806, 1884, 1908, 1997, 2141, 2

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