Effects of dietary ferulic acid supplementation on growth performance and skeletal muscle fiber type conversion in weaned piglets

Wang, Youxia; Chen, Xiaoling; Huang, Zhiqing; Chen, Shuai; Yu, Bing; Chen, Hong; Yu, Jie; Luo, Yuheng; Zheng, Ping; He, Jun

doi:10.1002/jsfa.11157

Cited by 21 publications

(13 citation statements)

References 41 publications

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“…An important clue to the basis of ferulic acid’s versatile protective effects may have been provided by recent studies reporting that, in low micromolar concentrations that are readily achievable with oral supplementation and likely by ingestion of anthocyanin-rich diets, ferulic acid upregulates expression of Sirt1 at both the mRNA and protein level. This effect has been demonstrated in chondrocytes, skeletal muscle fibres, testes, neural stem cells and hepatocytes, and hence may be broad in scope 6–11. Presumably, ferulic acid either upregulates transcription of the Sirt1 gene or prolongs the half-life of Sirt1 mRNA.…”

Section: Upregulation Of Sirt1 By Ferulic Acidmentioning

confidence: 95%

Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity

et al. 2022

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Ferulic acid, a bacterial metabolite of anthocyanins, seems likely to be a primary mediator of the health benefits associated with anthocyanin-rich diets, and has long been employed in Chinese cardiovascular medicine. In rodent studies, it has exerted wide-ranging antioxidant and anti-inflammatory effects, the molecular basis of which remains rather obscure. However, recent studies indicate that physiologically relevant concentrations of ferulic acid can boost expression of Sirt1 at mRNA and protein levels in a range of tissues. Sirt1, a class III deacetylase, functions to detect a paucity of oxidisable substrate, and in response works in various ways to promote cellular survival and healthful longevity. Sirt1 promotes ‘cell cleansing’ and cell survival by boosting autophagy, mitophagy, mitochondrial biogenesis, phase 2 induction of antioxidant enzymes via Nrf2, and DNA repair—while inhibiting NF-kB-driven inflammation, apoptosis, and cellular senescence, and boosting endothelial expression of the protective transcription factor kruppel-like factor 2. A deficit of the latter appears to mediate the endothelial toxicity of the SARS-CoV-2 spike protein. Ferulic acid also enhances the activation of AMP-activated kinase (AMPK) by increasing expression and activity of its activating kinase LKB1—whereas AMPK in turn amplifies Sirt1 activity by promoting induction of nicotinamide phosphoribosyltranferase, rate-limiting for generation of Sirt1’s obligate substrate NAD+. Curiously, AMPK acts by independent mechanisms to potentiate many of the effects mediated by Sirt1. Hence, it is proposed that ferulic acid may exert complementary or synergistic health-promoting effects when used in conjunction with clinically useful AMPK activators, such as the nutraceutical berberine. Additional nutraceuticals which might have potential for amplifying certain protective effects of ferulic acid/berberine are also discussed.

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Section: Upregulation Of Sirt1 By Ferulic Acidmentioning

confidence: 95%

Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity

et al. 2022

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“…A recent study in 21-day-old piglets demonstrated that FA could promote muscle fiber type conversion from fast-twitch to slow-twitch via the Sirt1/AMPK/PGC-1α signaling pathway, moreover a decrease of lactate dehydrogenase (LDH) activity, that is positively associated with glycolytic fibers confirming that FA could promote the transformation of muscle fiber type from fast-twitch to slow-twitch. [39].…”

Section: Morphometry Of Muscle Fibersmentioning

confidence: 99%

“…These differences in our study might be because FA does not bind to β 2 -AR and there might be other receptors or other mechanisms that recognize FA and promote muscle deposition. A recent study indicates that FA has mitochondrial and enzymatic pathways that promote fiber type conversion from fast-twitch to slow-twitch and myogenic regulators targeting hypertrophy in oxidative fibers [39]. Therefore, further research is required to confirm the initial action mechanism of FA to promote growth in lambs.…”

Section: Gene Expression In Longissimus Thoracis Musclementioning

confidence: 99%

Growth performance, carcass traits, muscle fiber characteristics and skeletal muscle mRNA abundance in hair lambs supplemented with ferulic acid

Peña-Torres¹,

Castillo-Salas²,

Jiménez‐Estrada³

et al. 2022

J Anim Sci Technol

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Ferulic acid (FA) is a phytochemical with various bioactive properties. It has recently been proposed that due to its phytogenic action it can be used as an alternative growth promoter additive to synthetic compounds. The objective of the present study was to evaluate the growth performance, carcass traits, fiber characterization and skeletal muscle gene expression on hair-lambs supplemented with two doses of FA. Thirty-two male lambs (n = 8 per treatment) were individually housed during a 32 d feeding trial to evaluate the effect of FA (300 and 600 mg d −1 ) or zilpaterol hydrochloride (ZH; 6 mg d −1 ) on growth performance, and then slaughtered to evaluate the effects on carcass traits, and muscle fibers morphometry from Longissimus thoracis (LT) and mRNA abundance of β 2 -adrenergic receptor (β 2 -AR), MHC-I, MHC-IIX and IGF-I genes. FA increased final weight and average daily gain with respect to non-supplemented animals (p ˂ 0.05). The ZH supplementation increased LT muscle area, with respect to FA doses and control (p ˂ 0.05). Cross-sectional area (CSA) of oxidative fibers was larger with FA doses and ZH (p ˂ 0.05). Feeding ZH increased mRNA abundance for β 2 -AR compared to FA and control (p ˂ 0.05), and expression of MHC-I was affected by FA doses and ZH (p ˂ 0.05). Overall, FA supplementation of male hair lambs enhanced productive variables due to skeletal muscle hypertrophy caused by MHC-I up-regulation. Results suggest that FA has the potential like a growth promoter in lambs.

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“…Ferulic acid has shown remarkable anti-inflammatory and antioxidant activity in pre-clinical studies and, as sodium ferulate, is widely used in cardiovascular medicine in China [90,91]. Recent studies have found that this may reflect, in large part, the ability of ferulic acid to up-regulate SIRT1 expression at the mRNA and protein level [92][93][94][95][96][97]. This effect has been demonstrated in a number of cell types, and hence appears to be a general effect; its mechanistic basis remains unclear.…”

Section: Manifold Nutraceutical and Dietary Options For Activation Of...mentioning

confidence: 99%

Nutraceutical and Dietary Strategies for Up-Regulating Macroautophagy

McCarty

2022

IJMS

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Macroautophagy is a “cell cleansing” process that rids cells of protein aggregates and damaged organelles that may contribute to disease pathogenesis and the dysfunctions associated with aging. Measures which boost longevity and health span in rodents typically up-regulate macroautophagy, and it has often been suggested that safe strategies which can promote this process in humans may contribute to healthful aging. The kinase ULK1 serves as a trigger for autophagy initiation, and the transcription factors TFEB, FOXO1, ATF4 and CHOP promote expression of a number of proteins which mediate macroautophagy. Nutraceutical or dietary measures which stimulate AMPK, SIRT1, eIF5A, and that diminish the activities of AKT and mTORC1, can be expected to boost the activities of these pro-autophagic factors. The activity of AMPK can be stimulated with the phytochemical berberine. SIRT1 activation may be achieved with a range of agents, including ferulic acid, melatonin, urolithin A, N1-methylnicotinamide, nicotinamide riboside, and glucosamine; correction of ubiquinone deficiency may also be useful in this regard, as may dietary strategies such as time-restricted feeding or intermittent fasting. In the context of an age-related decrease in cellular polyamine levels, provision of exogenous spermidine can boost the hypusination reaction required for the appropriate post-translational modification of eIF5A. Low-protein plant-based diets could be expected to increase ATF4 and CHOP expression, while diminishing IGF-I-mediated activation of AKT and mTORC1. Hence, practical strategies for protecting health by up-regulating macroautophagy may be feasible.

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Effects of dietary ferulic acid supplementation on growth performance and skeletal muscle fiber type conversion in weaned piglets

Cited by 21 publications

References 41 publications

Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity

Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity

Growth performance, carcass traits, muscle fiber characteristics and skeletal muscle mRNA abundance in hair lambs supplemented with ferulic acid

Nutraceutical and Dietary Strategies for Up-Regulating Macroautophagy

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