Effects of Dietary Folate Deficiency on Developmental Increase of Myelin Lipids in Rat Brain

Hirono, Haruko; Wada, Yoshiro

doi:10.1093/jn/108.5.766

Cited by 20 publications

(10 citation statements)

References 27 publications

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“…These FOLR1 mutants are defective in their binding to folate, and lead to inositol and choline insufficiencies, which in turn result in perturbed myelination (Steinfeld et al, 2009). This phenotype is similar to the disturbed myelination in 6-week-old rats fed with a folatedeficient diet (Hirono and Wada, 1978). Mutant forms of FOLR1 result in mislocalization of the protein and loss of FOLR1 from the cell membrane.…”

Section: Folate Action In Neurodegenerative Disease and Nervous Systementioning

confidence: 96%

Folate action in nervous system development and disease

Balashova

Visina²,

Borodinsky³

2018

Developmental Neurobiology

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The vitamin folic acid has been recognized as a crucial environmental factor for nervous system development. From the early fetal stages of the formation of the presumptive spinal cord and brain to the maturation and maintenance of the nervous system during infancy and childhood, folate levels and its supplementation have been considered influential in the clinical outcome of infants and children affected by neurological diseases. Despite the vast epidemiological information recorded on folate function and neural tube defects, neural development and neurodegenerative diseases, the mechanisms of folate action in the developing neural tissue have remained elusive. Here we compiled studies that argue for a unique role for folate in nervous system development and function and its consequences to neural disease and repair. © 2018 Wiley Periodicals, Inc. Develop Neurobiol 78: 391-402, 2018.

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Section: Folate Action In Neurodegenerative Disease and Nervous Systementioning

confidence: 96%

Folate action in nervous system development and disease

Balashova

Visina²,

Borodinsky³

2018

Developmental Neurobiology

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“…Conversely, rats fed 6 weeks on a low folate diet had decreased concentrations of DHA in plasma and platelets (Durand et al, 1996). Most importantly, dietary folate deficiency has been found to cause the depletion of DHA in rat nervous tissue (Hirono and Wada, 1978).…”

Section: Introductionmentioning

confidence: 99%

The relationship between folate and docosahexaenoic acid in men

et al. 2005

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Objective: Docosahexaenoic acid (DHA,, an essential omega 3 fatty acid, may protect against disorders of emotional regulation as well as cardiovascular disease. Animal studies demonstrate that dietary folate can increase tissue concentrations of DHA, although the literature, to date, includes no human studies examining the possibility that folate status may affect plasma DHA concentrations. The objective of this study is to determine if the blood concentrations of folate and DHA are correlated in humans. Design: Retrospective study. Setting: An American research hospital. Subjects: A total of 15 normal and 22 hostile and aggressive subjects, with a mean age of 38 years. Methods: Concentrations of plasma polyunsaturated essential fatty acids and red blood cell folate (RBC folate) were obtained prior to 1996, before American flour was enriched with folate. Results: RBC folate was significantly correlated with plasma DHA, r ¼ 0.57, P ¼ 0.005 in the aggressive group. Age, smoking and alcohol consumption did not alter the results. No other essential fatty acids were significantly associated with RBC folate in either group. Conclusions: The positive relationship between plasma DHA and RBC folate concentrations suggests that these two nutrients should be examined together in order to make the most accurate inferences about their relative contributions to disease pathogenesis. Our findings present one explanation why some conditions associated with hostility and low DHA status, such as cardiovascular disease and emotional disorders, are also associated with low folate status.

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“…These variations in MBP expression with folate status might have been at least partially attributable to differences in methyl status and methylation reactions. Folate deficiency was previously shown to decrease myelin lipids in rat brain [15] , and the low methylation status in our FD animals might have reduced the transmethylation reaction and thus decreased the synthesis of MBP.…”

Section: Discussionmentioning

confidence: 75%

“…While there is abundant evidence of the effect of folate intake on CNS development of the offspring [13][14][15] , little is known about its effects on the maternal MBP and brain during pregnancy and lactation. Therefore, this study examined the effects of dietary folic acid on the expressions of MBP and two markers for oligodendrocytes and neurons -myelin oligodendrocyte glycoprotein (MOG) and neuronal nuclear antigen (NeuN) -in the maternal brain and spinal cord at various reproductive states.…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Folic Acid on the Expression of Myelin Basic Protein in the Brain and Spinal Cord of Pregnant and Lactating Rats

Lee

et al. 2010

Ann Nutr Metab

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Background/Aims: This study investigated the effects of dietary folic acid on the expression of myelin basic protein (MBP) in the maternal brain and spinal cord during pregnancy and lactation. Methods: Female Sprague-Dawley rats were fed either a folic-acid-supplemented diet (FS, 8 mg/kg diet) or a folic-acid-deficient diet (FD, 0 mg/kg diet) from 2 weeks prior to mating until the end of lactation. The expressions of MBP were analyzed using Western blot analysis and immunohistochemistry, and myelin oligodendrocyte glycoprotein (MOG), and neuronal nuclear antigen by immunohistochemistry. Results: The cerebrocortical expression of MBP was 87% higher at day 20 of pregnancy than before pregnancy in FS animals (p < 0.05) but did not change significantly in FD animals. No significant change was observed in the hippocampus or spinal cord in either dietary treatment group. The cerebrocortical MOG and NeuN expressions were significantly lower in FD animals than in FS animals before pregnancy and increased at day 20 of pregnancy but did not differ with the dietary folic acid level. Conclusions: Folic acid deficiency did not increase the expression level of MBP in the cerebral cortex during pregnancy, suggesting that folate intake during pregnancy plays an important role in the maintenance of myelin.

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Effects of Dietary Folate Deficiency on Developmental Increase of Myelin Lipids in Rat Brain

Cited by 20 publications

References 27 publications

Folate action in nervous system development and disease

Folate action in nervous system development and disease

The relationship between folate and docosahexaenoic acid in men

Effects of Dietary Folic Acid on the Expression of Myelin Basic Protein in the Brain and Spinal Cord of Pregnant and Lactating Rats

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