Effects of Dietary Galactooligosaccharides on Immune System in Mice

Sato, Takeharu; Nakamura, Yasuyuki; Ozawa, O.

doi:10.4327/jsnfs.61.79

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…Fecal IgA concentrations in the GOS-fed mice did not change significantly but tended to be higher than those in the control mice (data not shown). However, in Balb/c mice, fecal IgA was reported to significantly increase 2 weeks after the start of GOS administration (27). Further studies are necessary to determine whether AD suppression was associated with modulation and/or acceleration of the immune response in the gut.…”

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confidence: 99%

Oral administration of a galactooligosaccharide preparation inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice

Tanabe

Hochi²

2010

Int J Mol Med

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Abstract. Anti-allergic effects of galactooligosaccharide (GOS), which is found in breast milk and frequently added to food for promoting health, were evaluated in a human-like mouse model of atopic dermatitis (AD). NC/Nga mice were fed 5.5% GOS for 8 weeks, and we examined whether this treatment suppressed the development of AD-like skin lesions in these mice. Mice fed GOS exhibited significantly less symptoms of dermatitis, reduced scratching frequency, and lower levels of serum total immunoglobulin E compared to control. At the end of the 8-week-experimental period, spleens were removed, and the splenocytes were stimulated with phorbol 12-myristate 13-acetate and ionomycin, following which production of cytokines and a chemokine was analyzed. Elevated levels of Th1 cytokines such as interferon-Á were observed in splenocytes from GOS-fed mice. However, the levels of Th2 cytokines such as interleukin (IL)-13 were unchanged. Furthermore, GOS inhibited the production of inflammatory cytokines such as IL-1ß, IL-6, IL-17, and tumor necrosis factor-· but enhanced production of immunomodulatory IL-10. The results indicate that GOS effectively blocked AD-like skin lesions in the mice by at least partly inducing production of IL-10 and suppressing the production of cytokines such as IL-17, which are involved in skin inflammation.

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confidence: 99%

Oral administration of a galactooligosaccharide preparation inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice

Tanabe

Hochi²

2010

Int J Mol Med

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“…There have been many reports indicating that ingestion of prebiotics increases production of IgA, which is important for protection against infection in the intestinal mucosa. Indigestible carbohydrates, such as fructooligosaccharides (FOS) [ 1 ], galactooligosaccharides (GOS) [ 2 ], and lactosucrose [ 3 ] have immunomodulating properties in the intestine that are associated with an increase in short-chain fatty acids and change in the composition of the intestinal microbiota in the intestine. Additionally, it has been reported that probiotic bacteria and beta-glucans sensitize the immune cells in the GALT and enhance production of antibodies; that is, intestinal contents other than absorbable nutrients are also deeply involved in the modulation of vital functions.…”

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confidence: 99%

Continuous intake of resistant maltodextrin enhanced intestinal immune response through changes in the intestinal environment in mice

Miyazato

Kishimoto

Takahashi

et al. 2016

Bioscience of Microbiota, Food and Health

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We investigated the effect of resistant maltodextrin (RMD), a non-viscous soluble dietary fiber, on intestinal immune response and its mechanism in mice. Intestinal and fecal immunoglobulin A (IgA) were determined as indicators of intestinal immune response, and changes in the intestinal environment were focused to study the mechanism. BALB/c mice were fed one of three experimental diets, a control diet or a diet containing either 5% or 7.5% RMD, for two weeks. Continuous intake of RMD dose-dependently increased total IgA levels in the intestinal tract. Total IgA production from the cecal mucosa was significantly increased by RMD intake, while there were no significant differences in mucosal IgA production between the control group and experimental groups in the small intestine and colon. Continuous intake of RMD changed the composition of the cecal contents; that is, the composition of the cecal microbiota was changed, and short-chain fatty acids (SCFAs) were increased. There was an increased trend in Bacteroidales in the cecal microbiota, and butyrate, an SCFA, was significantly increased. Our study demonstrated that continuous intake of RMD enhanced the intestinal immune response by increasing the production of IgA in the intestinal tract. It suggested that the increase in total SCFAs and changes in the intestinal microbiota resulting from the fermentation of RMD orally ingested were associated with the induction of IgA production in intestinal immune cells, with the IgA production of the cecal mucosa in particular being significantly increased.

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Absorption of the Indigestible Disaccharide, β-1,4-Mannobiose, from Coconut by the Rat Portal Vein

Kanatani¹,

Kimura²,

Asanoma³

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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Effects of Dietary Galactooligosaccharides on Immune System in Mice

Cited by 6 publications

References 23 publications

Oral administration of a galactooligosaccharide preparation inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice

Oral administration of a galactooligosaccharide preparation inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice

Continuous intake of resistant maltodextrin enhanced intestinal immune response through changes in the intestinal environment in mice

Absorption of the Indigestible Disaccharide, β-1,4-Mannobiose, from Coconut by the Rat Portal Vein

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