Effects of dietary
            <i>Glycyrrhiza</i>
            polysaccharide supplementation on growth performance, intestinal antioxidants, immunity and microbiota in weaned piglets

Zhang, Cai; Li, Chenxu; Zhao, Pengli; Shao, Qi; Ma, Yanbo; Bai, Dongying; Liao, Chengshui; He, Lei; Huang, Shucheng

doi:10.1080/10495398.2022.2086878

Cited by 9 publications

(6 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Akin to most clinical medicine, medical herbs, phytogenic, and phytocompounds have been used in animals through multiple mechanisms, including regulation of cell development, metabolism of nutrients, bacterial composition of gut microbiota, etc. Other studies have also reported that Glycyrrhiza uralensis-related products used as feed additives inhibit the relative amount of Enterobacter, Enterococcus, Clostridium and Bacteroides [50,51] and increase the relative abundance of Lactobacillus [52] at genus levels in weaned piglets. In this study, we analyzed gut microbiota to evaluate the relative amount of probiotic as well as pathogenic and zoonotic bacteria genera in growth-finishing pigs, indicated that GUE did not alter the bacterial composition gut microbiota in growth-finishing pigs (Figure 7).…”

Section: Discussionmentioning

confidence: 92%

Systematic Myostatin Expression Screening Platform for Identification and Evaluation of Myogenesis-Related Phytogenic in Pigs

Ou,

Hsu,

Haung

et al. 2023

Bioengineering

View full text Add to dashboard Cite

Skeletal muscle growth in livestock impacts meat quantity and quality. Concerns arise because certain feed additives, like beta-agonists, may affect food safety. Skeletal muscle is a specialized tissue consisting of nondividing and multinucleated muscle fibers. Myostatin (MSTN), a protein specific to skeletal muscle, is secreted and functions as a negative regulator of muscle mass by inhibiting the proliferation and differentiation of myoblasts. To enhance livestock muscle growth, phytogenic feed additives could be an alternative as they inhibit MSTN activity. The objective of this study was to establish a systematic screening platform using MSTN activity to evaluate phytogenics, providing scientific evidence of their assessment and potency. In this study, we established a screening platform to monitor myostatin promoter activity in rat L8 myoblasts. Extract of Glycyrrhiza uralensis (GUE), an oriental herbal medicine, was identified through this screening platform, and the active fractions of GUE were identified using a process-scale liquid column chromatography system. For in vivo study, GUE as a feed additive was investigated in growth-finishing pigs. The results showed that GUE significantly increased body weight, carcass weight, and lean content in pigs. Microbiota analysis indicated that GUE did not affect the composition of gut microbiota in pigs. In summary, this established rodent myoblast screening platform was used to identify a myogenesis-related phytogenic, GUE, and further demonstrated that the active fractions and compounds inhibited MSTN expression. These findings suggest a novel application for GUE in growth performance enhancement through modulation of MSTN expression. Moreover, this well-established screening platform holds significant potential for identifying and assessing a diverse range of phytogenics that contribute to the process of myogenesis.

show abstract

Section: Discussionmentioning

confidence: 92%

Systematic Myostatin Expression Screening Platform for Identification and Evaluation of Myogenesis-Related Phytogenic in Pigs

Ou,

Hsu,

Haung

et al. 2023

Bioengineering

View full text Add to dashboard Cite

show abstract

“…In vivo studies of polysaccharides have also demonstrated their ability to relieve inflammation. Zhang et al showed that dietary Glycyrrhiza polysaccharide supplementation can significantly increase the relative mRNA expression of sIgA, IL-10, TGF-β, and TLR-4 in weaned piglets and significantly downregulate the relative mRNA expression of IL-2 [ 45 ]. Additionally, Xie et al demonstrated that jejunal p-NF-κB and total NF-κB levels in pigs are inhibited following the addition of Enteromorpha polysaccharides–zinc to feed, and intestinal inflammation-related cytokines such IL-6, IL-8, IL-12, and TNF-α are downregulated [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Rehmannia glutinosa Polysaccharides: Optimization of the Decolorization Process and Antioxidant and Anti-Inflammatory Effects in LPS-Stimulated Porcine Intestinal Epithelial Cells

Ren

Yan

et al. 2023

Antioxidants

View full text Add to dashboard Cite

Polysaccharide decolorization has a major effect on polysaccharide function. In the present study, the decolorization of Rehmannia glutinosa polysaccharides (RGP) is optimized using two methods—the AB-8 macroporous resin (RGP-1) method and the H2O2 (RGP-2) method. The optimal decolorization parameters for the AB-8 macroporous resin method were as follows: temperature, 50 °C; macroporous resin addition, 8.4%; decolorization duration, 64 min; and pH, 5. Under these conditions, the overall score was 65.29 ± 3.4%. The optimal decolorization conditions for the H2O2 method were as follows: temperature, 51 °C; H2O2 addition, 9.5%; decolorization duration, 2 h; and pH, 8.6. Under these conditions, the overall score was 79.29 ± 4.8%. Two pure polysaccharides (RGP-1-A and RGP-2-A) were isolated from RGP-1 and RGP-2. Subsequently, their antioxidant and anti-inflammatory effects and mechanisms were evaluated. RGP treatment activated the Nrf2/Keap1 pathway and significantly increased the activity of antioxidant enzymes (p < 0.05). It also inhibited the expression of pro-inflammatory factors and suppressed the TLR4/NF-κB pathway (p < 0.05). RGP-1-A had a significantly better protective effect than RGP-2-A, likely owing to the sulfate and uronic groups it contains. Together, the findings indicate that RGP can act as a natural agent for the prevention of oxidation and inflammation-related diseases.

show abstract

“…The polysaccharide compounds in Cassia Semen are mostly water-soluble polysaccharides composed of galactose and mannose. The structure of the polysaccharides consists of a main chain of mannose linked through 1-4 connections, with a galactose molecule attached to the sixth carbon atom of every sixth mannose, forming a galactomannan [7].…”

Section: Polysaccharide Compoundsmentioning

confidence: 99%

Recent progress in the study of chemical constituents and pharmacological effects of Cassia Semen

Sang

2024

View full text Add to dashboard Cite

Cassia Semen is the mature seed of the leguminous plant Cassia obtusifolia L. or Cassia tora L. They are known for clearing heat, improving vision, and promoting bowel movements. Modern chemical research has shown that Cassia Semen is rich in anthraquinones, naphthopyranones, and fatty acids, among other chemical components. Pharmacological studies have demonstrated various effects of Cassia Semen, including lowering blood lipid levels, reducing blood pressure, regulating blood glucose, promoting bowel movements, protecting the liver, improving vision, exhibiting antioxidant and anti-aging properties, inhibiting bacteria, and exerting anti-cancer effects. By reviewing recent domestic and international modern research on Cassia Semen, this article provides a literature review on its chemical constituents, pharmacological effects, and recent progress in clinical studies. The aim is to offer references for the rational clinical application of Cassia Semen, the mechanisms of its pharmacological and toxicological effects, as well as the modern development of traditional Chinese medicine.

show abstract

Effects of dietary Glycyrrhiza polysaccharide supplementation on growth performance, intestinal antioxidants, immunity and microbiota in weaned piglets

Cited by 9 publications

References 52 publications

Systematic Myostatin Expression Screening Platform for Identification and Evaluation of Myogenesis-Related Phytogenic in Pigs

Systematic Myostatin Expression Screening Platform for Identification and Evaluation of Myogenesis-Related Phytogenic in Pigs

Rehmannia glutinosa Polysaccharides: Optimization of the Decolorization Process and Antioxidant and Anti-Inflammatory Effects in LPS-Stimulated Porcine Intestinal Epithelial Cells

Recent progress in the study of chemical constituents and pharmacological effects of Cassia Semen

Contact Info

Product

Resources

About