Effects of Dietarymyo-Inositol,<scp>D</scp>-chiro-Inositol and<scp>L</scp>-chiro-Inositol on Hepatic Lipids with Reference to the Hepaticmyo-Inositol Status in Rats Fed on 1,1,1-Trichloro-2,2-bis (p-chlorophenyl) Ethane

Okazaki, Yukako; Setoguchi, Tomoyasu; Katayama, Takahiro

doi:10.1271/bbb.60257

Cited by 10 publications

(8 citation statements)

References 20 publications

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“…It has been reported that inositol hexaphosphate and inositol can inhibit chemically induced rat hepatocarcinogenesis (Lee, Lee, & Choi, ). As the backbone and precursor of inositol phosphates, inositol is primarily used to treat diabetes (Dang, Mukai, Yoshida, & Ashida, ), hepatitis (Okazaki, Setoguchi, & Katayama, ), polycystic ovary syndrome (Santamaria et al, ), colorectal cancer (Fu, Song, Wen, Lu, & Cui, ) and other diseases. Inositol exhibits moderate anticancer activity, and it synergistically enhances the inhibitory effects of inositol hexaphosphate on the growth of colon (Shamsuddin, Ullah, & Chakravarthy, ) and mammary cancers (Vucenik, Yang, & Shamsuddin, ).…”

Section: Discussionmentioning

confidence: 99%

Identification of differential metabolic characteristics between tumor and normal tissue from colorectal cancer patients by gas chromatography–mass spectrometry

Meng

et al. 2017

Biomedical Chromatography

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Colorectal cancer (CRC) is one of the most common human malignancies and encompasses cancers of the colon and rectum. Although the gold-standard colonoscopy screening method is effective in detecting CRC, this method is invasive and can result in severe complications for patients. The purpose of this study was to determine differences in metabolites between CRC and matched adjacent nontumor tissues from CRC patients, to identify potential biomarkers that may be informative and developed screening methods. Metabolomic analysis was performed on clinically localized CRC tissue and matched adjacent nontumor tissue from 20 CRC patients. Unsupervised analysis, supervised analysis, univariate analysis and pathway analysis were used to identify potential metabolic biomarkers of CRC. The levels of 25 metabolites in CRC tissues were significantly altered compared with the matched adjacent nontumor tissues. Four metabolites (lactic acid, alanine, phosphate and aspartic acid) demonstrated good area under the curve of receiver-operator characteristic with acceptable sensitivities and specificities, indicating their potential as important biomarkers for CRC. Alterations of amino acid metabolism and enhanced glycolysis may be major factors in the development and progression of CRC. Lactic acid, alanine, phosphate, and aspartic acid could be effective diagnostic indicators for CRC.

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Section: Discussionmentioning

confidence: 99%

Identification of differential metabolic characteristics between tumor and normal tissue from colorectal cancer patients by gas chromatography–mass spectrometry

Meng

et al. 2017

Biomedical Chromatography

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“…[96] Theinsecticide DDT,when fed to rats,causes increases in liver weight and hepatic lipids.T he coadministration of lchiro-o rd-chiro-inositol with DDT promotes this effect. [97] 5.4. d-chiro-Inositol in Diabetes, Pregnancy,and Polycystic Ovary Syndrome d-chiro-Inositol is ac omponent, along with galactosamine,ofanuncharacterized modulator of insulin function:it stimulates pyruvate dehydrogenase phosphatase [98] and allosterically activates protein phosphatase 2C. [99] Athree-day fast causes a2 0% drop in the amount of d-chiro-inositol in muscle,w hich may contribute to the insulin resistance that occurs after short-term starvation.…”

Section: Biology and Medicinementioning

confidence: 99%

ChemInform Abstract: The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo‐Inositol Chemistry)

2016

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“…Ins is a saturated, circular, polyhydric alcohol that serves as the backbone and precursor of inositol phosphates. It is primarily used to treat diabetes, hepatitis, polycystic ovary syndrome [ 11 , 12 , 13 ], cardiovascular disease and other diseases. It exhibits moderate anticancer activity, and it synergistically enhances the inhibitory effects of IP6 on the growth of colon and mammary cancers [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Inositol Hexaphosphate and Inositol Inhibit Colorectal Cancer Metastasis to the Liver in BALB/c Mice

Song

Zhaoxia

et al. 2016

Nutrients

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Inositol hexaphosphate (IP6) and inositol (Ins), naturally occurring carbohydrates present in most mammals and plants, inhibit the growth of numerous cancers both in vitro and in vivo. In this study, we first examined the anti-metastatic effects of IP6 and Ins using a liver metastasis model of colorectal cancer (CRC) in BALB/c mice. CT-26 cells were injected into the splenic capsule of 48 BALB/c mice. The mice were then randomly divided into four groups: IP6, Ins, IP6 + Ins and normal saline control (n = 12 per group). IP6 and/or Ins (80 mg/kg each, 0.2 mL/day) were injected into the gastrointestinal tracts of the mice on the second day after surgery. All mice were sacrificed after 20 days, and the tumor inhibition rates were determined. The results demonstrated that the tumor weights of liver metastases and the tumor inhibition rates were reduced in the experimental groups compared to the control group and that treatment with the combination of IP6 and Ins resulted in greater inhibition of tumor growth than treatment with either compound alone. These findings suggest that IP6 and Ins prevent the development and metastatic progression of colorectal cancer to the liver in mice by altering expression of the extracellular matrix proteins collagen IV, fibronectin and laminin; the adhesion factor receptor integrin-β1; the proteolytic enzyme matrix metalloproteinase 9; and the angiogenic factors vascular endothelial growth factor, basic fibroblast growth factor, and transforming growth factor beta in the tumor metastasis microenvironment. In conclusion, IP6 and Ins inhibited the development and metastatic progression of colorectal cancer to the liver in BALB/c mice, and the effect of their combined application was significantly greater than the effect of either compound alone. This evidence supports further testing of the combined application of IP6 and Ins for the prevention of colorectal cancer metastasis to the liver in clinical studies.

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Effects of Dietarymyo-Inositol,D-chiro-Inositol andL-chiro-Inositol on Hepatic Lipids with Reference to the Hepaticmyo-Inositol Status in Rats Fed on 1,1,1-Trichloro-2,2-bis (p-chlorophenyl) Ethane

Cited by 10 publications

References 20 publications

Identification of differential metabolic characteristics between tumor and normal tissue from colorectal cancer patients by gas chromatography–mass spectrometry

Identification of differential metabolic characteristics between tumor and normal tissue from colorectal cancer patients by gas chromatography–mass spectrometry

ChemInform Abstract: The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo‐Inositol Chemistry)

Inositol Hexaphosphate and Inositol Inhibit Colorectal Cancer Metastasis to the Liver in BALB/c Mice

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