The effect of feeding broccoli byproduct-wheat straw silage (BBWS) (69:31 ratio, DM basis) on performance, microbial N synthesis (MNS), rumen and blood parameters in Fashandy lambs were evaluated. Three diets, with equal metabolisable energy and crude protein (CP) with a forage to concentrate ratio of 27:73 (DM basis), were formulated in which forage (lucerne and wheat straw) was replaced by BBWS (0, 100, or 200 g/kg of diet DM). These were assigned to 3 groups (n = 15/group) in a completely randomized block design for a 70-d period in which diets were offered as a total mixed ration. For each animal, dry matter intake (DMI), average daily gain (ADG), in vivo apparent digestibility, MNS, N retention, rumen and blood parameters were measured. The BBWS diets had no influence on DMI, ADG, and feed conversion efficiency, in vivo apparent digestibility coefficients of DM, OM, CP, and ash-free NDF. Neither MNS and N retention nor serum concentrations of glucose, triglycerides, creatinine, cholesterol, urea N, triiodothyronine, thyroxine, total protein, albumin, and globulin were affected. Rumen pH, NH3-N, short-chain fatty acid concentrations, the ratio of acetic to propionic acid, and protozoa numbers were, also, not influenced. In summary, BBWS may be fed to Fashandy lambs up to 200 g/kg of diet DM without any adverse impacts on growth performance.