Effects of dietary Jatropha curcas on the haematology of weaned pigs

Chivandi, Eliton; Makuza, S. M.; Erlwanger, Kennedy Honey; Mtimuni, J. P.; Read, John S.; Tivapasi, Musavenga T.

doi:10.4314/zvj.v31i3.5360

Cited by 9 publications

(8 citation statements)

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“…Feeding of J. curcas seeds, fruits or leaves caused toxicity depending on the dose and the animal species tested. Raw or defatted seeds when force-fed to fish, chicks, pigs, goat, mice and rats caused severe toxicity symptoms before death [84][85][86][87][88]. Various organic and aqueous extract also exhibited different toxic symptoms depending on dose, mode of administration and sensitivity of the animals being tested [89][90][91].…”

Section: Phorbol Estersmentioning

confidence: 99%

Jatropha Diterpenes: a Review

Devappa

Makkar

Becker

2010

J Americ Oil Chem Soc

144

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Terpenes are the largest group of phytochemicals that exhibit diverse functions in mediating antagonistic and beneficial interactions in, and among, organisms. For many years the abundance and distribution of terpenoid compounds in plants have benefitted both nature and human civilization. Jatropha species, belonging to the family Euphorbiaceae, are a rich source of terpenoid compounds. Among the terpenes, diterpenoid compounds have dominated the research area in Jatropha species with respect to their novel chemical structures and medicinal values. The present review describes the chemistry and biological activities of an array of Jatropha diterpenes. The diterpenes isolated from Jatropha species belongs to rhamnofolane, daphnane, lathyrane, tigliane, dinorditerpene, deoxy preussomerin and pimarane skeletal structures. Among the 68 diterpenes collated in this review, the biological activity of compounds varied distinctly-the majority of the diterpenes exhibited cytotoxic, antitumor and antimicrobial activities in vitro. To name a few, jatrophone, spruceanol and jatrophatrione exhibited antitumor properties against P338 lymphocytic leukemia and japodagrol against KB carcinoma cells. Whereas, curcusone B exhibited anti-invasive effects against cholangiocarcinoma cells. The phorbol esters (Jatropha factor C1-C6) and Jatropherol exhibited insect deterrent/cytotoxic properties. Many diterpenes (jatrophalactam, faveline derivatives, multifolone, curcusone, jatrophone derivatives etc.) showed in-vitro cytotoxic activity, while japodagrin, jatrogrossidione derivatives and jatropholone derivatives exhibited antimicrobial activities. Jatropha diterpenoids having a wide spectrum of bioactivity could form lead compounds or could be used as templates for the synthesis of new compounds with better biological activity for utilization in the pharmaceutical industries.

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Section: Phorbol Estersmentioning

confidence: 99%

Jatropha Diterpenes: a Review

Devappa

Makkar

Becker

2010

J Americ Oil Chem Soc

144

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“…Methanol fraction from J. curcas oil induced tumor promotion upon topical initiation by Makkar et al [11], dimethylbenz(a)anthracene (DMBA) in mice, with 36% of the animals having skin tumors in 30 weeks [12]. Raw or defatted seeds when administered to fish, chicks, pigs, goats, mice, and rats were associated with toxic symptoms before death [13, 14]. Different aqueous extracts also exhibited different toxic symptoms depending on dose, mode of administration, and sensitivity of the animals that were tested [15, 16].…”

Section: Introductionmentioning

confidence: 99%

Effects of Biochemical Alteration in Animal Model after Short‐Term Exposure of Jatropha curcas (Linn) Leaf Extract

Igbinosa

Oviasogie

Igbinosa

et al. 2013

The Scientific World Journal

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This study aims to evaluate potential toxic effect of Jatropha curcas leaves methanol extract on laboratory rats as well as determine its LD50. A total of 80 male Wistar rats were used as the experimental animals, 40 for LD50 determination and the other 40 for toxicity study. Based on the pretest that was done in order to establish a range of toxicity, 4 dosages (86.00, 58.00, 46.00, and 34.0 kg/body weight) were chosen. The rats were randomly assigned into four groups with 10 rats in each group. Rats in groups 1, 2, 3, and 4 were given 0 mg/kg, 500 mg/kg, 1000 mg/kg, and 2000 mg/kg body weight of Jatropha curcas extract, respectively, by oral intubation for 21 days. Thereafter, clinical signs, change in body weight, toxicity symptoms, and biochemical parameters were obtained. The LD50 at 95% confidence limits for rats was 46.0 mg/kg body weight (44.95–52.69 mg/kg body mass). There was no clinical and biochemical signs of toxicity when the extract was administered at 500, 1000, and 2000 mg/kg body weight, respectively (P > 0.05). Results obtained from this study suggest that liver, kidney, and haematological system of rats tolerated methanolic leave extract of Jatropha curcas at a certain concentration.

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“…One of the most important nutritional requirements of animals is protein and, in most locally formulated rations in Malawi, this comes from Soybeans. Its wide use in feed rations is the result of the high protein, lysine and energy contents as well as its palatability 4 …”

Section: Introductionmentioning

confidence: 99%

“…Its wide use in feed rations is the result of the high protein, lysine and energy contents as well as its palatability. 4 Raw soybean cannot efficiently be utilized by livestock because of presence of anti-nutritional factors (ANFs) among which trypsin inhibitor is the most important. [5][6][7] Most of these ANFs have recently received attention as they affect protein digestibility and acceptance.…”

Section: Introductionmentioning

confidence: 99%

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The effect of the length of soaking time on trypsin inhibitor, crude protein and phosphorus contents of soybeans (Glycine max)

Mumba

Chilera

alinafe

2003

Int J Consumer Studies

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A study to determine the effect of soaking soybeans (Glycine max) at different periods of time on trypsin inhibitor, crude protein and phosphorus contents was carried out. The results showed that the length of soaking period had significant effect (P < 0.05) on trypsin inhibitor and crude protein contents. The activities of the trypsin inhibitor were 10% in roasted soybeans, 27.5% in raw and a range of 26.6% for those soaked in water for 24 h to 17.7% for soybeans soaked for 96 h or more, with a standard error of 6.56 on each of the values. The crude protein contents were 41.58% in raw, 31.43% in roasted and a range of 40.05–30.64% for those soaked in water for 24–120 h. The standard error on each value was 5.09%. On the other hand, length of soaking period had no significant effect on phosphorus content. It can be concluded from this that soaking soybeans in water can effectively remove the anti‐nutritional factors. While roasting is better, the use of fire wood may not be encouraged as it has caused a lot of deforestation with consequent occurrence of floods and hence food shortages. Such a good animal husbandry practice can help to improve the health of animals, which can in turn help to improve the health of the population.

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Effects of dietary Jatropha curcas on the haematology of weaned pigs

Cited by 9 publications

References 0 publications

Jatropha Diterpenes: a Review

Jatropha Diterpenes: a Review

Effects of Biochemical Alteration in Animal Model after Short‐Term Exposure of Jatropha curcas (Linn) Leaf Extract

The effect of the length of soaking time on trypsin inhibitor, crude protein and phosphorus contents of soybeans (Glycine max)

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