Effects of dietary micelle silymarin on the growth performance, feed utilization and health of olive flounder (Paralichthys olivaceus)

Kim, Han-Se; Jo, Sehee; Yun, Kwan-Sik; Lee, Kyeong‐Jun

doi:10.1007/s10499-023-01135-2

Cited by 2 publications

(3 citation statements)

References 45 publications

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“…It is worth noting that the increase in total antioxidant levels on the 21st day of the experiment indicated a potential protective effect of silymarin against oxidative stress induced by diazinon exposure. Kim et al [ 56 ] found that the total antioxidant capacity in the hepatocytes of olive flounder ( Paralichthys olivaceus ) was enhanced by feeding them a diet supplemented with micelle silymarin.…”

Section: Discussionmentioning

confidence: 99%

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Evaluating Silymarin Extract as a Potent Antioxidant Supplement in Diazinon-Exposed Rainbow Trout: Oxidative Stress and Biochemical Parameter Analysis

Banaee,

Impellitteri,

Multisanti

et al. 2023

Toxics

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This study aimed to investigate the effects of diazinon on fish, focusing on hepatotoxic biomarkers and the potential protective effects of silymarin supplementation. One hundred eighty rainbow trout were randomly assigned to four groups: control, diazinon exposed (0.1 mg L−1), silymarin supplemented (400 mg kg−1), and diazinon + silymarin. Blood samples and liver tissue were collected after 7, 14, and 21 days of exposure to analyze biochemical parameters and oxidative biomarkers. Diazinon exposure in fish resulted in liver damage, as indicated by increased antioxidant enzyme activities in the hepatocytes. Silymarin showed the potential to mitigate this damage by reducing oxidative stress and restoring enzyme activities. Nevertheless, diazinon increased creatine phosphokinase activity, which may not be normalized by silymarin. Exposure to diazinon increased glucose, triglyceride, and cholesterol levels, whereas total protein, albumin, and globulin levels were significantly decreased in fish. However, silymarin controlled and maintained these levels within the normal range. Diazinon increased creatinine, urea, uric acid, and ammonia contents. Silymarin could regulate creatinine, urea, and uric acid levels while having limited effectiveness on ammonia excretion. Furthermore, diazinon increased malondialdehyde in hepatocytes, whereas administration of silymarin could restore normal malondialdehyde levels. Overall, silymarin showed potential as a therapeutic treatment for mitigating oxidative damage induced by diazinon in fish, but its effectiveness on creatine phosphokinase, glutathione reductase, and ammonia may be limited.

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Section: Discussionmentioning

confidence: 99%

“…This result indicated that silymarin had a protective effect against the oxidative damage induced by diazinon. A significant decrease in MDA contents was reported in the hepatocytes of olive flounder ( P. olivaceus ) fed with silymarin [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluating Silymarin Extract as a Potent Antioxidant Supplement in Diazinon-Exposed Rainbow Trout: Oxidative Stress and Biochemical Parameter Analysis

Banaee,

Impellitteri,

Multisanti

et al. 2023

Toxics

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“…Regarding its use in fish farming, some studies investigated the potential effects of silymarin on fish growth, health, and disease prevention. The results showed that dietary supplementation with silymarin improved the growth performance and health status of fish in several species (e.g., Pangasianodon hypophthalmus [30], Scophthalmus maximus [31], Oreochromis niloticus [32], or Oncorhynchus mykiss [26], Paralichthys olivaceus [33], Dicentrarchus labrax [34], or Cyprinus carpio [35]).…”

Section: Introductionmentioning

confidence: 99%

The Antioxidant and Hepatoprotective Potential of Berberine and Silymarin on Acetaminophen Induced Toxicity in Cyprinus carpio L.

Grădinariu,

Dediu,

Crețu

et al. 2024

Animals

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Berberine (BBR) and silymarin (SM) are natural compounds extracted from plants known for their antioxidant and chemoprotective effects on the liver. The present study aimed to investigate the beneficial properties of BBR and SM and the association of BBR with SM on liver function using fish as “in vivo” models. Moreover, the study investigated their hepatoprotective role after acetaminophen (APAP) exposure. For this purpose, the fish (N = 360; 118.4 ± 11.09 g) were fed with control or experimental diets for 9 weeks. In the experimental diets, the feed was supplemented with either SM (1 g/kg feed), BBR (100 and 200 mg/kg feed), or a combination of BBR with SM (SM 1 g/kg feed + BBR 100 mg/kg feed and, respectively, SM 1 g/kg feed + BBR 200 mg/kg feed). After the feeding trial, seven fish from each tank were randomly selected and exposed to a single APAP dose. The selected serum biochemical markers, oxidative stress markers, and lysozyme activity were used to evaluate the efficiency of the supplements on carp’s health profile, particularly regarding the hepatopancreas function. Our results showed that the inclusion of SM and BBR (either as a single or in combination) reduced the serum contents of total cholesterol, triglyceride, and alanine transaminase. An increase in the high-density cholesterol was observed after the administration of BBR or BBR in association with SM. Both supplements showed hepatoprotective activity against APAP-induced hepatotoxicity, especially BBR. The ameliorative effects of SM (1 g) in association with BBR (100 mg) were highlighted by the modulation of the nonspecific immune system and oxidative stress alleviation after APAP exposure.

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Effects of dietary micelle silymarin on the growth performance, feed utilization and health of olive flounder (Paralichthys olivaceus)

Cited by 2 publications

References 45 publications

Evaluating Silymarin Extract as a Potent Antioxidant Supplement in Diazinon-Exposed Rainbow Trout: Oxidative Stress and Biochemical Parameter Analysis

Evaluating Silymarin Extract as a Potent Antioxidant Supplement in Diazinon-Exposed Rainbow Trout: Oxidative Stress and Biochemical Parameter Analysis

The Antioxidant and Hepatoprotective Potential of Berberine and Silymarin on Acetaminophen Induced Toxicity in Cyprinus carpio L.

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