Effects of dietary phytic acid on serum and hepatic lipid levels in diabetic KK mice

Lee, Sung-Hyeon; Park, Hong-Ju; Cho, So-Young; Jung, Hyuk-Sang; Cho, Soo-Mook; Cho, Yong-Sick; Lillehoj, Hyun S.

doi:10.1016/j.nutres.2005.09.004

Cited by 38 publications

(33 citation statements)

References 16 publications

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“…They observed lower serum total cholesterol and low-density lipoprotein cholesterol concentrations as well as hepatic total lipid and total cholesterol due to an increase in the level of dietary phytic acid from 0 to 1.5%. Similarly, Lee et al (2007) reported lower serum low-density lipoprotein cholesterol and hepatic triacylglycerol in aged mice due to an increase in dietary phytic acid from 0 to 1.5%. In their study, the apparent absorption of total lipid and cholesterol was also reduced, whereas fecal cholesterol and lipid contents were increased by the dietary phytic acid.…”

Section: Effect Of Phytic Acid On Energy Digestibilitymentioning

confidence: 83%

“…Lee et al (2005) fed diabetic mice diets containing 0, 1 and 1.5% phytic acid to investigate the effect of phytic acid on the levels of lipids in the serum and liver. They observed lower serum total cholesterol and low-density lipoprotein cholesterol concentrations as well as hepatic total lipid and total cholesterol due to an increase in the level of dietary phytic acid from 0 to 1.5%.…”

Section: Effect Of Phytic Acid On Energy Digestibilitymentioning

confidence: 99%

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Review: Anti-nutritional effects of phytic acid in diets for pigs and poultry – current knowledge and directions for future research

2013

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Woyengo, T. A. and Nyachoti, C. M. 2013. Review: Anti-nutritional effects of phytic acid in diets for pigs and poultry Á current knowledge and directions for future research. Can. J. Anim. Sci. 93: 9Á21. Plant feedstuffs contain phytic acid (PA), which is a storage form of phosphorus. Phytic acid is, however, poorly hydrolyzed by pigs and poultry, and it has a capacity to complex dietary nutrients, thereby reducing nutrient digestibility. Reduced nutrient digestibility by PA implies reduced efficiency of utilization of the nutrients and increased discharge of the unabsorbed nutrients to the environment. Phytic acid has also recently been shown to increase the endogenous nutrient losses (ENL) in pigs and poultry. Because the increased ENL in the gastrointestinal tract are associated with increased maintenance requirement for the lost nutrients and of energy spent on their secretion, an increase in ENL due to PA implies that there are other adverse effects of PA on nutrient utilization in addition to reducing nutrient digestibility. In this review, the effects of PA on performance of pigs and poultry, and on the digestibility and ENL in these animals are discussed in detail. Also, the mechanisms by which PA reduces nutrient digestibility and increases gastrointestinal ENL in pigs and poultry are discussed, and areas that need further research to gain more insight into these mechanisms are suggested.Key words: Phytic acid, pig, poultry, nutrient utilization Woyengo, T. A. et Nyachoti, C. M. 2013. Effets anti-nutritionnels de l'acide phytique dans la ration des porcs et de la volaille Á connaissances actuelles et pistes pour les recherches a`venir. Can. J. Anim. Sci. 93: 9Á21. Les aliments ve´ge´taux renferment de l'acide phytique (AP), compose´servant a`stocker le phosphore. Malheureusement, les porcs et la volaille hydrolysent mal cet acide, qui, de plus, a tendance a`rendre les nutriments plus complexes, donc a`en re´duire la digestibilite´. Une digestibilite´plus faible des e´le´ments nutritifs suppose en retour une assimilation moins efficace et l'expulsion dans l'environnement d'une plus grande quantite´de nutriments non absorbe´s. Re´cemment, on a aussi montre´que l'AP augmente les pertes endoge`nes de nutriments (PEN) chez le porc et la volaille. L'augmentation des PEN dans le tube digestif est associe´e aux besoins de maintenance plus e´leve´s ne´cessaires pour compenser les nutriments perdus et l'e´nergie de´pense´e lors de leur se´cre´tion. La hausse des PEN attribuable a`l'AP laisse pre´sumer que celui-ci a d'autres effets secondaires sur l'assimilation des nutriments qu'une digestibilite´re´duite. L'analyse examine en de´tail les conse´quences de l'AP sur le rendement des porcs et de la volaille et sur la digestibilite´ainsi que les PEN chez ces animaux. On y discute aussi des me´canismes par lesquels l'AP re´duit la digestibilite´des nutriments et augmente les PEN dans le tube digestif des porcs et de la volaille. Les auteurs pre´conisent qu'on approfondissent les recherches dans ces domaines afin d'en...

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Section: Effect Of Phytic Acid On Energy Digestibilitymentioning

confidence: 83%

Section: Effect Of Phytic Acid On Energy Digestibilitymentioning

confidence: 99%

Review: Anti-nutritional effects of phytic acid in diets for pigs and poultry – current knowledge and directions for future research

2013

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“…(182) ); insulin and/or plasma cholesterol and TAG (688 -690) ; lipid levels in liver and serum (691) ; detoxification capacity of liver and levels of GSH transferase and cytochrome P-450 (692) ; immune response (99) ; renal stones (693) ; calcification of cardiovascular system (694) ; dental caries and platelet aggregation, treatment of hypercalciura and kidney stones, and Pb poisoning (218) ; gene expression (695,696) Resistant starch (697) :…”

Section: Appendixmentioning

confidence: 99%

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

2010

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Epidemiological studies have clearly shown that whole-grain cereals can protect against obesity, diabetes, CVD and cancers. The specific effects of food structure (increased satiety, reduced transit time and glycaemic response), fibre (improved faecal bulking and satiety, viscosity and SCFA production, and/or reduced glycaemic response) and Mg (better glycaemic homeostasis through increased insulin secretion), together with the antioxidant and anti-carcinogenic properties of numerous bioactive compounds, especially those in the bran and germ (minerals, trace elements, vitamins, carotenoids, polyphenols and alkylresorcinols), are today well-recognised mechanisms in this protection. Recent findings, the exhaustive listing of bioactive compounds found in whole-grain wheat, their content in whole-grain, bran and germ fractions and their estimated bioavailability, have led to new hypotheses. The involvement of polyphenols in cell signalling and gene regulation, and of sulfur compounds, lignin and phytic acid should be considered in antioxidant protection. Whole-grain wheat is also a rich source of methyl donors and lipotropes (methionine, betaine, choline, inositol and folates) that may be involved in cardiovascular and/or hepatic protection, lipid metabolism and DNA methylation. Potential protective effects of bound phenolic acids within the colon, of the B-complex vitamins on the nervous system and mental health, of oligosaccharides as prebiotics, of compounds associated with skeleton health, and of other compounds such as a-linolenic acid, policosanol, melatonin, phytosterols and para-aminobenzoic acid also deserve to be studied in more depth. Finally, benefits of nutrigenomics to study complex physiological effects of the 'whole-grain package', and the most promising ways for improving the nutritional quality of cereal products are discussed. Whole-grain wheat: Bioactive compounds: Physiological mechanisms: Health IntroductionThere is growing evidence that whole-grain cereal products protect against the development of chronic diseases. The most important of these in terms of public health are obesity (1,2) , the metabolic syndrome (3,4) , type 2 diabetes (5,6) , CVD (7) and cancers (8 -12) . Whole-grain cereal consumption has also been shown to be protective against mortality, as was shown with inflammation-related death (i.e. noncardiovascular and non-cancer inflammatory diseases such as, for example, respiratory system diseases) (13) and with cancer and CVD (4,14,15) . These conclusions are supported by the effects of consuming refined cereal products (bread, pasta and rice), as these have been associated with an increased risk of digestive tract, pharynx, larynx and thyroid cancers in northern Italians (16) . However, an association between a lower risk of developing a chronic disease and a high whole-grain cereal consumption does not mean a direct causal relationship and provides no information about the physiological mechanisms involved.These metabolic diseases are related to our daily lifestyle, no...

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“…Phytic acid is also an antioxidant [42], an anticancer agent [43,44] and a useful agent against diabetes [45,46]. It can form soluble and insoluble complexes with proteins [47,48].…”

Section: Treatment With Phytic Acidmentioning

confidence: 99%

Peanut proteins: Applications, ailments and possible remediation

Ghatak

Sen

2013

Journal of Industrial and Engineering Chemistry

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Effects of dietary phytic acid on serum and hepatic lipid levels in diabetic KK mice

Cited by 38 publications

References 16 publications

Review: Anti-nutritional effects of phytic acid in diets for pigs and poultry – current knowledge and directions for future research

Review: Anti-nutritional effects of phytic acid in diets for pigs and poultry – current knowledge and directions for future research

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

Peanut proteins: Applications, ailments and possible remediation

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