Effects of dietary polyamines at physiologic doses in early-weaned piglets

Sabater-Molina, María; Larqué, Elvira; Torrella, F.; Plaza, Javier; Lozano, Teresa; Muñoz, Antonio; Zamora, Salvador

doi:10.1016/j.nut.2009.01.017

Cited by 42 publications

(41 citation statements)

References 37 publications

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“…Our finding that spermine supplementation altered morphology of the gastrointestinal tract is consistent with previous outcomes in 14-day-old suckling (Cheng et al, 2006;Sabater-Molina et al, 2009) and 24-day-old weaned (Kang et al, 2012) piglets. However, the currently observed increase in villus height and decrease in crypt depth contrasts with the reduced villus height and increased crypt depth observed in piglets receiving a spermine supplement before 2 weeks of age (Cheng et al, 2006;Sabater-Molina et al, 2009).…”

Section: Discussionsupporting

confidence: 92%

“…However, the currently observed increase in villus height and decrease in crypt depth contrasts with the reduced villus height and increased crypt depth observed in piglets receiving a spermine supplement before 2 weeks of age (Cheng et al, 2006;Sabater-Molina et al, 2009). It is plausible that these differences reflect the ages of the piglets used, and animal age has been identified as a critical determinant of the intestinal response to spermine Values within a row, and main effect, with different superscript letters differ significantly at P < 0.01.…”

Section: Discussionmentioning

confidence: 74%

“…The differing intestinal response to spermine supplementation in the present compared with previous studies may also be attributed to differences in the concentrations provided. Based on the mean spermine levels present in milk (Sabater-Molina et al, 2009), the dose provided in the present study was designed to represent an approximate increase of 20% above the daily level consumed via the milk. The concentrations of spermine used in the previous studies were all substantially higher than those used in the present study: 10 times (Sabater-Molina et al, 2009), 1891 times (Cheng et al, 2006) and between 324 and 1971 times (Kang et al, 2012) the current dose.…”

Section: Discussionmentioning

confidence: 99%

“…The doses of spermine and spermidine used were calculated to provide 20% more than normally received in sow's milk. This figure was based on an estimated average intake of 950 ml/piglet per day, and sows milk containing 4.87 nmol/ml of spermine and 21.19 nmol/ml of spermidine (Sabater-Molina et al, 2009). …”

Section: Methodsmentioning

confidence: 99%

“…Spermidine concentrations in sow's milk increase as lactation progresses peaking on day 49 of lactation (Kelly et al, 1991). Oral supplementation with spermine advanced intestinal maturation in piglets dosed from 2 to 15 days of age (Sabater-Molina et al, 2009) and 11 to 14 days of age (Cheng et al, 2006). However, animal age appears to be a critical determinant of the intestinal response to spermine supplementation (Shimizu et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

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Effect of oral polyamine supplementation pre-weaning on piglet growth and intestinal characteristics

Wettere

Willson

Pain

et al. 2016

Animal

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A high proportion of piglets fail to adapt to the changing composition of their diet at weaning, resulting in weight loss and increased susceptibility to pathogens. Polyamines are present in sow milk and promote neonatal maturation of the gut. We hypothesised that oral spermine and spermidine supplementation before weaning would increase piglet growth and promote gastrointestinal development at weaning. In Experiment One, one pair of liveweight (LW)-matched piglets per litter from first and third lactation sows received 2 ml of a 0 (Control) or 463 nmol/ml spermine solution at 14, 16, 18, 20 and 22 days of age (n = 6 piglets/treatment per parity). Villus height and crypt depth in the duodenum and jejunum were measured at weaning (day 23 postpartum). In Experiment Two, piglets suckling 18 first and 18 third lactation sows were used. Within each litter, piglets received 2 ml of either water (Control), 463 nmol/ml spermine solution or 2013 nmol/ml spermidine solution at 14, 16, 18, 22 and 24 days of age (n = 54 piglets/treatment per sow parity). Piglets were weighed individually at 14, 18, 24 (weaning) and 61 days of age. In Experiment One, oral spermine supplementation resulted in a 41% increase in villus height, a 21% decrease in crypt depth and 79% decrease in the villus height : crypt depth ratio compared with control piglets ( P < 0.01). In Experiment Two, spermine and spermidine-supplemented piglets suckling first lactation sows grew faster ( P < 0.05) between days 14 and 18 postpartum than control piglets: 0.230 ± 0.011 and 0.227 ± 0.012 v. 0.183 ± 0.012 kg/day, respectively. Spermine supplementation tended ( P < 0.1) to increase piglet LW gain from weaning to day 37 post-weaning compared with control piglets (0.373 ± 0.009 v. 0.341 ± 0.010 kg/day). In conclusion, spermine supplementation increased villus height at weaning, and appears to have the potential to improve the pre-and post-weaning growth of conventionally weaned piglets.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of oral polyamine supplementation pre-weaning on piglet growth and intestinal characteristics

Wettere

Willson

Pain

et al. 2016

Animal

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Current Status of the Polyamine Research Field

Pegg

Casero

2011

Methods in Molecular Biology

205

175

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This chapter provides an overview of the polyamine field and introduces the 32 other chapters that make up this volume. These chapters provide a wide range of methods, advice, and background relevant to studies of the function of polyamines, the regulation of their content, their role in disease, and the therapeutic potential of drugs targeting polyamine content and function. The methodology provided in this new volume will enable laboratories already working in this area to expand their experimental techniques and facilitate the entry of additional workers into this rapidly expanding field.

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Dietary fructooligosaccharides and potential benefits on health

et al. 2009

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Fructooligosaccharides (FOS) are oligosaccharides that occur naturally in plants such as onion, chicory, garlic, asparagus, banana, artichoke, among many others. They are composed of linear chains of fructose units, linked by beta (2-1) bonds. The number of fructose units ranges from 2 to 60 and often terminate in a glucose unit. Dietary FOS are not hydrolyzed by small intestinal glycosidases and reach the cecum structurally unchanged. There, they are metabolized by the intestinal microflora to form short-chain carboxylic acids, L -lactate, CO(2), hydrogen and other metabolites. FOS have a number of interesting properties, including a low sweetness intensity; they are also calorie free, non-cariogenic and are considered as soluble dietary fibre. Furthermore, FOS have important beneficial physiological effects such as low carcinogenicity, a prebiotic effect, improved mineral absorption and decreased levels of serum cholesterol, triacylglycerols and phospholipids. Currently FOS are increasingly included in food products and infant formulas due to their prebiotic effect stimulate the growth of nonpathogenic intestinal microflora. Their consumption increases fecal bolus and the frequency of depositions, while a dose of 4-15 g/day given to healthy subjects will reduce constipation, considered one of the growing problems of modern society, and newborns during the first months of life.

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Effects of dietary polyamines at physiologic doses in early-weaned piglets

Cited by 42 publications

References 37 publications

Effect of oral polyamine supplementation pre-weaning on piglet growth and intestinal characteristics

Effect of oral polyamine supplementation pre-weaning on piglet growth and intestinal characteristics

Current Status of the Polyamine Research Field

Dietary fructooligosaccharides and potential benefits on health

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