Effects of dietary quercetin on the innate immune response and resistance to white spot syndrome virus in Procambarus clarkii

Zhang, Yunfei; Xiao, Chongyang; Zhu, Faming

doi:10.1016/j.fsi.2021.09.012

Cited by 15 publications

(5 citation statements)

References 44 publications

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“… 28 , 29 Adding quercetin to the diet may also affect the innate immunity of crayfish and protect crayfish from white spot syndrome virus infection. 30 A study showed that quercetin could weaken the effect of hydrogen peroxide on endoplasmic reticulum morphology and tyrosinase output in melanocytes. 31 Kaempferol decreased the expression of major proinflammatory cytokines in psoriatic lesions and down-regulated the signal of proinflammatory nuclear factor kappa B (NF-κB) in the skin.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Potential Molecular Mechanism of Sijunzi Decoction in the Treatment of Non-Segmental Vitiligo Based on Network Pharmacology and Molecular Docking

Du¹,

Wang²,

Gao³

et al. 2023

CCID

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Background Non-segmental vitiligo is a common decolorized skin disease. The purpose of this study was to reveal the active components of Sijunzi decoction (SJZD) and the target genes for the treatment of non-segmental vitiligo. Methods Based on TCMSP and GEO databases, effective components and targets of SJZD in the treatment of non-segmental vitiligo were revealed by network pharmacology. GO and KEGG were used to analyze the biological functions of SJZD targets. The Cytoscape-cytoHubba plugin was used to identify hub target genes. SsGSEA method was used to analyze the infiltration level of immune cells in non-segmental vitiligo. Molecular docking was performed to predict the interaction between active compounds and hub target genes. Finally, real-time PCR detection was also performed. Results It was found that 104 active compounds may be effective ingredients in the treatment of non-segmental vitiligo. These 104 compounds acted on 42 differentially expressed target genes. KEGG analysis showed that target genes were significantly enriched in immune-related pathways such as MAPK and TNF signaling pathways. A total of 6 hub target genes (AKT1, CASP3, PPARG, SIRT1, TNF and TP53) were identified using the Cytoscape-cytoHubba plugin. Molecular docking showed that active compounds quercetin, kaempferol, formononetin and naringenin had good binding to hub target genes. We also found that Type 2 T helper cells, CD56bright natural killer cell and CD56dim natural killer cell infiltration levels were abnormal in non-segmental vitiligo and correlated with AKT1. Conclusion The results of this study indicate that quercetin, kaempferol, formononetin and naringenin in SJZD may play an important role in the treatment of non-segmental vitiligo by acting on AKT1, CASP3, PPARG, SIRT1, TNF and TP53 to regulate immune cell infiltration and multiple signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Exploring the Potential Molecular Mechanism of Sijunzi Decoction in the Treatment of Non-Segmental Vitiligo Based on Network Pharmacology and Molecular Docking

Du¹,

Wang²,

Gao³

et al. 2023

CCID

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“…Quercetin is a flavonoid which is present in many fruits and vegetables, such as white onion bulbs, fennel leaves, red onion, sweet potatoes, berries, citrus fruits, and tea [12]. Anti-inflammatory, antioxidant, and anti-cancer characteristics are just a few of the health advantages of quercetin [13]. In many neurodegenerative conditions, the combination of anti-inflammatory and antioxidant properties can increase neuron survival and help to decrease cell death, delaying the onset of disease [14].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Protective and Ameliorative Role of Quercetin Nanoparticles against Histopathological Changes Induced in the Cerebral Cortex of Rats by Acrolein

sanad,

nasar,

Farouk

2024

Bulletin of Faculty of Science, Zagazig University

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Alzheimer's disease is the most prevalent cause of dementia. The flavonoid quercetin has low bioavailability. Quercetin nanoparticles have been shown to have greater bioavailability. The purpose of the current investigation was to assess any potential histopathological damage caused by acrolein in the cerebral cortex. The potential effects of quercetin nanoparticles against the neurotoxicity caused by acrolein were also investigated. In the present investigation, rats were divided into six groups as follows: control group; acrolein-treated group in which rats were given acrolein (3 mg/kg) for 30 days; quercetin nanoparticles treated group in which rats were given quercetin nanoparticles (30 mg/kg) for 30 days; ameliorative group in which rats were given acrolein and quercetin nanoparticles at the same time daily for 30 days; protective group in which rats received first quercetin nanoparticles for 30 days, followed by acrolein for another 30 days; recovery group in which rats received acrolein for 30 days, and they left without any treatment for an additional 30 days. The results indicated that acrolein administration was linked to histopathological changes and significant damage in the cerebral cortex. These were visible in acute ischemia neuronal damage, which was manifested as nuclear pyknosis, neuronophagia, and focal areas of Malacia connected to gliosis. It has been resulted that the treatment of rats with quercetin nanoparticles protected and improved the cerebral cortex from the oxidative stress caused by acrolein. This result could pave the way for additional research in nanomedicine and a new line of therapeutic intervention in Alzheimer's disease using nanoparticles.

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“…Applying bioactive immunostimulants is safe from chemical residues, serves as an alternative to antibiotics, is environmentally friendly, and significantly enhances the immune system of aquatic animals (Van Hai, 2015;Vijayaram et al, 2022). Herbal plants containing phenolic and flavonoid compounds have been reported to enhance innate immune in shrimp, such as the herbal plant zingerone, Scutellaria baicalensis, and Galla chinensis (Chang et al, 2012;Pan and Yan, 2020), Procambarus clarkia (Zhang et al, 2021) and Ocimum basilicum (Abdel-Tawwab et al, 2022). The immunity parameters with normal range in shrimp are total hemocyte count (THC) 4.10 -5.01 x 10 6 cell mL -1 , and differential hemocyte count (DHC), , and semi granular cells (45.03-50.85%) (Fadjar et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

In Silico and In Vivo Potential of Fraction Red Betel Leaf as an Immunostimulant Agent in White-leg Shrimp

Saputra,

Andayani

et al. 2023

WVJ

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Production of white-leg shrimp (Litopenaeus vannamei) in aquaculture with advanced technology ultimately results in high mortality rates in cultivation. Infectious diseases, including Vibrio spp., can cause mortality with necrosis symptoms in the white-leg shrimp hepatopancreas. Disease prevention through enhancing immunity is highly effective in controlling diseases in shrimps. The current study aimed to obtain information on the compounds present in the fraction of Piper (P.) crocatum as an immunostimulant agent used in silico. The current study investigated the absorption, distribution, metabolism, excretion, and toxicity (ADME/T), and determined the optimal fraction dosage of P. crocatum when injected as an immunostimulant substance. In this study, in silico analysis was conducted by accessing several servers, while the shrimp’s immune response was evaluated using a completely randomized design experiment with four treatments (10 individuals/container) and three replications, including 0 (control), 0.5 µg/g, 1 µg/g, and 1.5 µg/g. The shrimp’s immunity was examined by injecting the P. crocatum fraction initially, followed by a second injection 24 hours later. Shrimp hemolymph was collected before the injection of the P. crocatum fraction and 24 hours after the injection. Hemolymph was collected at both time intervals to assess total hemocyte count (THC), differential hemocyte count (DHC), and phenoloxidase (PO) as the immune response of shrimp before and after administration of P. crocatum fraction. Two compounds were confirmed immunostimulant agents in a fraction of P. crocatum, 2-Amino-1,3,4-octadecanetriol, and erucamide. The immune response values for THC (14.17 ± 2.45 × 106 cells mL-1), DHC hyaline (53 ± 4.5%), semi-granular cells (52 ± 4.0%), and granular cells (43 ± 40%), and PO (0.112 ± 0.016 units/λ=490) at a concentration of 1.5 µg/g showed a significant increase in number and percentage compared to the control. These results indicate the presence of two compounds in fraction one P. crocatum, as candidates for immunostimulant agents. Administration of 1.5 µg/g of a fraction of P. crocatum is the appropriate dose as an immunostimulant agent when administered via injection method for white-leg shrimp.

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Effects of dietary quercetin on the innate immune response and resistance to white spot syndrome virus in Procambarus clarkii

Cited by 15 publications

References 44 publications

Exploring the Potential Molecular Mechanism of Sijunzi Decoction in the Treatment of Non-Segmental Vitiligo Based on Network Pharmacology and Molecular Docking

Exploring the Potential Molecular Mechanism of Sijunzi Decoction in the Treatment of Non-Segmental Vitiligo Based on Network Pharmacology and Molecular Docking

Assessment of the Protective and Ameliorative Role of Quercetin Nanoparticles against Histopathological Changes Induced in the Cerebral Cortex of Rats by Acrolein

In Silico and In Vivo Potential of Fraction Red Betel Leaf as an Immunostimulant Agent in White-leg Shrimp

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