Effects of dietary resveratrol supplementation in sows on antioxidative status, myofiber characteristic and meat quality of offspring

Meng, Qiang; Sun, Shishuai; Bai, Yongsong; Luo, Zhengrong; Li, Zhongyu; Shi, Baoming; Shan, Anshan

doi:10.1016/j.meatsci.2020.108176

Cited by 41 publications

(29 citation statements)

References 45 publications

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“…From these results, dietary RES supplementation alleviated some gastrointestinal diseases caused by the oxidative stress-induced decrease of Tenericutes abundance in weaned piglets via increasing the abundance of Actinobacteria. Interestingly, OSOs and RES exposure failed to affect the alpha-diversity of the gut microbiome of piglets, suggesting similar ecological diversity of the colonic microbiota of piglets after different treatments, which was consistent with the previous research 40 .…”

Section: Discussionsupporting

confidence: 91%

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Resveratrol Alleviates Oxidative Stress Induced by Oxidized Soybean Oils and Improves Gut Function via Changing Gut Microbiota in Weaned Piglets

Gao

Meng

Song

et al. 2022

Preprint

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Background: The objective of this study was to investigate the effects of dietary resveratrol supplementation on growth performance, redox status, inflammatory state, and intestinal function of weaned piglets fed oxidized soybean oils.Methods: A total of twenty-eight castrated weaned male piglets with a similar body weight of 10.19 ±1 kg were randomly assigned to 4 dietary treatments for 28 days feeding trial with 7 replications per treatment and 1 piglet per replicate. Treatments were arranged as a 2×2 factorial with oil type [fresh soybean oils (FSOs) vs. oxidized soybean oils (OSOs)] and dietary resveratrol (RES) (0 vs. 300 mg/kg).Result: Inclusion of OSOs decreased the villus/crypt ratio (VCR), while the villus height (VH) and VCR in the jejunum of weaned piglets was increased by dietary RES (P< 0.05). The activities of lipase, chymotrypsin, and lactase were decreased by OSOs, however dietary RES supplementation increased the activities of lipase, chymotrypsin, lactase, and α-amylase in the jejunum of weaned piglets (P< 0.05). Dietary RES increased the apparent digestibility of crude fat (EE). Dietary RES supplementation in the diets supplemented with OSOs decreased the level of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) in the plasma of weaned piglets, but failed to influence the IL-1β, IL-6, IL-8, and TNF-α level when diets supplemented with FSOs. Dietary RES alleviated the decrease of total-superoxide dismutase activity in the plasma of weaned piglets fed OSOs (P< 0.05). Dietary supplemented with OSOs and RES decreased the level of H2O2 in the plasma of weaned piglets (P< 0.05). RES alleviates the intestinal barrier damage fed OSOs in weaned piglets by increasing the mRNA expression of ZO-1 and Occludin. It is noteworthy that inclusion of OSOs in diets increased the abundance of Actinobacteria, and decreased the abundance of Tenercutes (P< 0.05). RES increased the abundance of Firmicutes, and decreased the abundance of Bacteroidetes (P< 0.05). At the genus level, RES decreased the abundance of Prevotella-1, Prevotellaceae UCG003, and Clostridium_sensu_stricto_6 in the colon. OSOs decreased the level of acetic acid, and dietary RES increased the level of acetic acid and butyric acid in the colon of weaned piglets.Conclusions: Dietary RES supplementation improved the villus-crypt structure, digestive enzyme activities and alleviated OSOs induced digestive absorption disorder. In addition, RES may alleviate OSOs immune status and energy metabolism of weaned piglets by affecting gut microbiota and its metabolite SCFAs. Notably, this positive effect of RES on OSOs may be related to decrease in the abundance of Prevotella_1 and Prevotellaceae_UCG-003.

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Section: Discussionsupporting

confidence: 91%

“…Besides, dietary RES increased the SOD2 mRNA expression in the jejunum. Previous studies have also observed that RES improved the activities of various antioxidant enzymes 39,40 . In this study, OSOs increased the activity of DAO, while RES decreased the DAO activity and D-lactate content in the plasma of weaned piglets.…”

Section: Discussionmentioning

confidence: 68%

Resveratrol Alleviates Oxidative Stress Induced by Oxidized Soybean Oils and Improves Gut Function via Changing Gut Microbiota in Weaned Piglets

Gao

Meng

Song

et al. 2022

Preprint

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“…In this study, curcumin supplementation significantly inhibited the reduction in pH values among curcumin groups compared to the control group; this phenomenon may be related to changes in the antioxidant capacity. Supplementing the diet with antioxidants increased pH values in the meat of pigs and ducks—as the antioxidation capacity of animals was upregulated [ 16 , 28 ]. Shear force is an indicator of meat tenderness, reflecting the content and nature of connective tissue and the chemical structural state of the myofibrillar protein in muscle.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, increasing the levels of dietary curcumin in ducks significantly reduced shear force values. Meng et al (2020) reported that supplementing the diet with antioxidants decreased the shear force levels of pork as the antioxidation capacity increased and improved meat quality [ 28 ]. Drip loss is an indicator used to evaluate the sample water-holding capacity.…”

Section: Discussionmentioning

confidence: 99%

Effect of Dietary Curcumin Supplementation on Duck Growth Performance, Antioxidant Capacity and Breast Meat Quality

Jin

Yang

Liu

et al. 2021

Foods

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This study aimed at examining the effects of curcumin supplementation on growth performance, antioxidant capacity, and meat quality of ducks. To investigate these effects, 600 healthy ducks were randomly assigned to four treatment groups with 10 replicates pens, and each pen contained 15 ducks. Ducks were fed a diet containing curcumin at levels of 0, 300, 400, and 500 mg kg−1 in different groups. The results demonstrated that curcumin supplementation is beneficial to the growth performance (p < 0.05) of ducks and antioxidant capacity (p < 0.05) of duck meat. In addition, dietary curcumin raised the meat quality of ducks, improving the meat color, increasing water-holding capacity, and inhibiting lipid and protein oxidation. In conclusion, the present study provides important insights into both the nutrient and qualities of ducks, finding that a dietary inclusion of 400–500 mg/kg of curcumin (kg−1) has the greatest effect.

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“…Moreover, R has also been demonstrated to affect lipid metabolism, cell proliferation, differentiation, and apoptosis [ 39 , 40 , 41 ]. In farm animals, R-supplemented feed has been already tested with some positive results (e.g., in broilers [ 32 , 42 , 43 ] and swine [ 44 , 45 ]), thus, suggesting that this approach can be effectively implemented in farming practice. Moreover, recent advances in the extraction of R from grape pomace or Polygonum cuspidatum [ 46 , 47 , 48 ] lead us to believe that potential low-cost green processing for the fortification of feed products with this antioxidant might be soon introduced.…”

Section: Introductionmentioning

confidence: 99%

Discovering the Protective Effects of Resveratrol on Aflatoxin B1-Induced Toxicity: A Whole Transcriptomic Study in a Bovine Hepatocyte Cell Line

et al. 2021

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Aflatoxin B1 (AFB1) is a natural feed and food contaminant classified as a group I carcinogen for humans. In the dairy industry, AFB1 and its derivative, AFM1, are of concern for the related economic losses and their possible presence in milk and dairy food products. Among its toxic effects, AFB1 can cause oxidative stress. Thus, dietary supplementation with natural antioxidants has been considered among the strategies to mitigate AFB1 presence and its toxicity. Here, the protective role of resveratrol (R) has been investigated in a foetal bovine hepatocyte cell line (BFH12) exposed to AFB1, by measuring cytotoxicity, transcriptional changes (RNA sequencing), and targeted post-transcriptional modifications (lipid peroxidation, NQO1 and CYP3A enzymatic activity). Resveratrol reversed the AFB1-dependent cytotoxicity. As for gene expression, when administered alone, R induced neglectable changes in BFH12 cells. Conversely, when comparing AFB1-exposed cells with those co-incubated with R+AFB1, greater transcriptional variations were observed (i.e., 840 DEGs). Functional analyses revealed that several significant genes were involved in lipid biosynthesis, response to external stimulus, drug metabolism, and inflammatory response. As for NQO1 and CYP3A activities and lipid peroxidation, R significantly reverted variations induced by AFB1, mostly corroborating and/or completing transcriptional data. Outcomes of the present study provide new knowledge about key molecular mechanisms involved in R antioxidant-mediated protection against AFB1 toxicity.

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Effects of dietary resveratrol supplementation in sows on antioxidative status, myofiber characteristic and meat quality of offspring

Cited by 41 publications

References 45 publications

Resveratrol Alleviates Oxidative Stress Induced by Oxidized Soybean Oils and Improves Gut Function via Changing Gut Microbiota in Weaned Piglets

Resveratrol Alleviates Oxidative Stress Induced by Oxidized Soybean Oils and Improves Gut Function via Changing Gut Microbiota in Weaned Piglets

Effect of Dietary Curcumin Supplementation on Duck Growth Performance, Antioxidant Capacity and Breast Meat Quality

Discovering the Protective Effects of Resveratrol on Aflatoxin B1-Induced Toxicity: A Whole Transcriptomic Study in a Bovine Hepatocyte Cell Line

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