Effects of Dietary Schizandra chinensis, Brussels sprouts and Illicium verum extracts on carcinogen metabolism systems in mouse liver

Hendrich, Suzanne; Bjeldanes, Leonard F.

doi:10.1016/0278-6915(86)90317-0

Cited by 18 publications

(4 citation statements)

References 32 publications

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“…These detoxi fication enzymes, such as GSTs can reduce carcinogenicity by conjugation reactions with GSH, which is an efficient biochemical mechanism that transforms the carcinogen to a compound with lower biological activity and increased excretability (12,14). Previously Brussels sprouts have been found to influence hepatic and intestinal GSTs in rodents (7,(27)(28)(29)(30)(31)(32). In humans evidence for induction of biotransformation enzymes by dietary Effects of Brussels sprouts on GSTs in humans anticarcinogenic compounds is sparse.…”

Section: Discussionmentioning

confidence: 99%

Effects of consumption of Brussels sprouts on intestinal and lymphocytic glutathione S-transferases in humans

et al. 1995

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A high intake of glucosinolate-containing cruciferous vege tables, such as Brussels sprouts (Brassica oleraceae), has been linked to a decreased cancer risk, but the underlying mechanism is still unclear. The aim of this study was to reveal possible modulating effects of consumption of Brussels sprouts on duodenal, rectal and lymphocytic (i) glutathione S-transferase (GST) enzyme activity, (ii) GST isozyme levels and (iii) glutathione (GSH) content. Ten healthy non-smoking volunteers were randomly assigned to two groups in a cross-over design. Five persons started on a glucosinolate-free diet (control period), while the other five consumed 300 g/day cooked Brussels sprouts, at the expense of 300 g glucosinolate-free vegetables (sprouts period). After 7 days the regimen was changed for a further week. At the end of both periods blood samples and duodenal and rectal biopsies were taken. Mean GST activity showed marked differences between duodenal, rectal and lymphocytic cytosols (737 ± 54, 321 ± 29 and 154 ± 14 nmol/min/mg protein respectively), but was uninfluenced by the dietary regimen. Isozyme distribution varied greatly between the tissues. In duodenum GST-a, -7C and -[i iso zymes were expressed in considerable amounts (8441 ± 1365,3002 ± 223 and 536 ± 248 ng/mg protein respectively). Rectal biopsies also contained above three GST classes, but here GST-n was the most pronounced expressed isozyme (2849 ± 246) followed by GST-|n (495 ± 242), while GSTa was only present in minor quantities (149 ± 31). In lymphocytes only GST-71; (755 ± 96) and GST-p, (83 ± 54) could be detected. As a result of the dietary regimen rectal GST-a and -71 levels were slightly increased at the end of the sprouts period, by 30 and 15% respectively. GSH contents were uninfluenced by the dietary regimen. In conclusion, consumption of glucosinolate-containing Brussels sprouts for 1 week results in increased rectal GST-a and -tc isozyme levels. We hypothesize that these enhanced detoxification enzyme levels may partly explain the epidemiological association between a high intake of glucosinolates (cruciferous vegetables) and a decreased risk of colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Effects of consumption of Brussels sprouts on intestinal and lymphocytic glutathione S-transferases in humans

et al. 1995

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“…Interestingly, however, the antimutagenic activity of Ephedra sinica has been noted both in vitro and in vivo (Horikawa et al, 1994). Furthermore, the acetone extract of Coix lachryma-jobi has also been shown to inhibit the growth of tumour in mice (Numata et al, 1994), and the effect of Illicium verum extract on a carcinogen metabolism system in mouse liver has also been reported (Henrich, 1983;Henrich, 1986). It could be postulated that the antiangiogenic activity of these plants, rather than their cytotoxicity, might contribute to their antitumour action.…”

Section: Resultsmentioning

confidence: 93%

Inhibitory effects of Vietnamese medicinal plants on tube‐like formation of human umbilical venous cells

Nam

Kim

Bae

et al. 2003

Phytotherapy Research

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Seven of 58 plant materials from Vietnamese medicinal plants showed strong to moderate inhibitory activity on the tube-like formation induced by human umbilical venous endothelial cells in the in vitro angiogenesis assay. These plant materials include the herb of Ephedra sinica, leaves and stem of Ceiba pentandra, seed of Coix lachryma-jobi, rhizome of Drynaria fortunei, fruits and stem of Illicium verum and stem of Bombax ceiba. Of these, the methanol extracts of the herb of Ephedra sinica and stem of -Ceiba pentandra exhibited the strongest activities with inhibition percentages of 89.3% and 87.5% at 30 and 100 microgram/mL, respectively.

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“…chinensis is well known for its medicinal properties and has been used in traditional medicine, especially in China and Russia. The active compounds in S. chinensis seeds have been characterized and several animal studies have shown the beneficial effects of S. chinensis phytochemicals, for example, it has been shown that S. chinensis extracts can induce cell-cycle arrest in breast cancer cells [10]. S. chinensis extracts have also been tested in combination with other chemotherapeutic agents, including carbon tetrachloride, halothane, 3′-methyl-4-dimethylamino-azobenzene, deoxycholic acid, hepatotoxins, hydrogen peroxide, and doxorubicin [20].…”

Section: Discussionmentioning

confidence: 99%

“…chinensis seed extracts (SCSEs) have been shown to inhibit the growth of cultured human breast cancer cells by arresting the cell cycle [10]. The in vivo effects of SCSEs have also been studied using mouse and rat models.…”

Section: Introductionmentioning

confidence: 99%

Effect of <i>Schisandra chinensis</i> (Turcz) Schisandraceae seed extracts and cisplatin on cytotoxicity, genotoxicity and wound healing in MCF-7 cells

Li¹,

Yang²

2018

Trop. J. Pharm Res

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Purpose: Schisandra chinensis is a plant used in traditional Chinese and Russian medicine. An S. chinensis seed extract was tested for its ability to potentiate the effects of the anticancer agent cisplatin in MCF-7 breast cancer cells. Methods: S. chinensis seeds were extracted with ethanol and the ethanol was evaporated from the extracts to obtain an aqueous fraction of the S. chinensis seed extract (SCSE). MCF-7 cells were exposed to cisplatin alone or in combination with various concentrations of SCSE. The end points that

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Effects of Dietary Schizandra chinensis, Brussels sprouts and Illicium verum extracts on carcinogen metabolism systems in mouse liver

Cited by 18 publications

References 32 publications

Effects of consumption of Brussels sprouts on intestinal and lymphocytic glutathione S-transferases in humans

Effects of consumption of Brussels sprouts on intestinal and lymphocytic glutathione S-transferases in humans

Inhibitory effects of Vietnamese medicinal plants on tube‐like formation of human umbilical venous cells

Effect of <i>Schisandra chinensis</i> (Turcz) Schisandraceae seed extracts and cisplatin on cytotoxicity, genotoxicity and wound healing in MCF-7 cells

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