2023
DOI: 10.1055/a-2041-1516
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Effects of Dietary Sodium and Protein Intake on Glomerular Filtration Rate in Subjects with Type 2 Diabetes Treated with Sodium-Glucose Cotransporter 2 Inhibitors

Abstract: Background: Approximately one forth of patients treated with SGLT2 inhibitors (SGLT2i) experience an acute estimated glomerular filtration rate (eGFR) reduction of more than 10% (“dippers”). High sodium and protein intake can increase intraglomerular pressure and predispose to a decline of renal function. We investigated whether measured creatinine clearance (CrCl) is a sensitive enough method to detect the initial dip of GFR and if dietary sodium and protein intake might influence the extent of the early cha… Show more

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