Effects of dietary soy protein on skeletal muscle volume and strength in humans with various physical activities

Hashimoto, Ryohei; Sakai, Atsuko; Murayama, Masumi; Ochi, Arisa; Abe, Tomoki; Hirasaka, Katsuya; Ohno, Ayako; Teshima-Kondo, Shigetada; Yanagawa, Hiroaki; Yasui, Natsuo; Inatsugi, Mikiko; Doi, Daisuke; Takeda, Masanori; Mukai, Rie; Terao, Junji; Nikawa, Takeshi

doi:10.2152/jmi.62.177

Cited by 25 publications

(22 citation statements)

References 18 publications

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“…weight maintenance or diet-induced modest weight loss), on muscle composition in older adults with overweight or obesity. Protein supplementation (10 g/day) was associated with increased thigh muscle cross-sectional area (MSCA) in bedridden, frail older adults (>70 years), whereas the current study population represents the average US older adult who is still active, independent, and not severely protein-malnourished [ 53 ]. Therefore, current results suggest that higher dietary protein intake for 12 weeks does not influence muscle composition in healthy older adults with overweight or obesity.…”

Section: Discussionmentioning

confidence: 99%

Effects of a High-Protein Diet Including Whole Eggs on Muscle Composition and Indices of Cardiometabolic Health and Systemic Inflammation in Older Adults with Overweight or Obesity: A Randomized Controlled Trial

et al. 2018

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Age-related increases in intermuscular adipose tissue (IMAT) impair muscle quality, decrease functional capacity, and promote several cardiometabolic and inflammatory disorders. Whether these age-related alterations in muscle composition improve by consuming a high-protein (HP) diet with whole eggs are unclear. This parallel-design, randomized-controlled trial assessed the effects of a 12-week eucaloric HP diet with three whole eggs per day (1.4 g protein kg−1 day−1) versus a normal-protein diet void of eggs (NP, 0.8 g protein kg−1 day−1) on muscle composition (IMAT), cardiometabolic health, and systemic inflammation in older adults with overweight or obesity (12 men and 10 women; age 70 ± 5 years, BMI 31.3 ± 3.2 kg/m2, mean ± SD). No changes in muscle composition were observed over time, independent of protein intake. Total body weight was reduced in both groups (−3.3 ± 1.2%) and lean mass was preserved only with the HP diet. LDL concentration and hip circumference decreased only with the NP diet, while MCP-1 and HsCRP concentrations increased over time in both groups. A HP diet with whole eggs promotes lean mass retention with modest weight loss, but does not positively influence muscle composition, cardiometabolic health or systemic inflammation, compared to a NP diet void of eggs.

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Section: Discussionmentioning

confidence: 99%

Effects of a High-Protein Diet Including Whole Eggs on Muscle Composition and Indices of Cardiometabolic Health and Systemic Inflammation in Older Adults with Overweight or Obesity: A Randomized Controlled Trial

et al. 2018

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“…Effect of protein source on muscle hypertrophy may vary depending on exercise intensity as well. For example, Hashimoto et al had reported the soy protein supplementation increased skeletal muscle volume compared with caseinate supplementation in the subjects under the low physical activity but not high physical activity [24]. Additionally, in the bedridden patients, caseinate supplementation significantly increased skeletal muscle volume than no supplementation while its significant increase was not observed by soy protein supplementation [24].…”

Section: Discussionmentioning

confidence: 99%

Effect of different sources of dietary protein on muscle hypertrophy in functionally overloaded mice

Aoyama

Hirooka

Shimoda

et al. 2019

Biochemistry and Biophysics Reports

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Dietary protein intake is important for skeletal muscle protein synthesis. In this study, we investigated the differential effect of protein sources on hypertrophy of plantaris muscle induced by surgical ablation of gastrocnemius and soleus muscles. Six-week old mice were fed diets containing caseinate, whey, or soy as protein sources for 2 weeks. Plantaris muscle hypertrophy was induced by a unilateral ablation of synergistic muscles after a week. Food intake of soy protein-fed mice was higher than that of caseinate and whey-fed mice, resulting in higher body and fat weights. Plantaris muscle weight in sham-operated mice was not different across the groups. Overload-operated plantaris muscle weight and increased ratio of overloaded muscle to sham-operated muscle weights were higher in caseinate-fed mice than in whey- and soy protein-fed mice, suggesting caseinate as a promising protein source for muscle hypertrophy.

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“…However, this study did not demonstrate any differences in exercise capacity between the different supplementation groups. Conversely, genistein or soy supplementation has been shown to provide several benefits in vivo or in vitro on muscle, including preventing atrophy [ 19 , 20 ], modulating metabolism [ 21 , 22 ], and promoting regeneration [ 23 , 24 ]. Here, we show that SPE, SPC and SPI consumption led to increased muscle function compared with MPI, did not display any detrimental effects and were equivalent in efficacy to WPI.…”

Section: Discussionmentioning

confidence: 99%

Chronic dietary supplementation with soy protein improves muscle function in rats

et al. 2017

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Athletes as well as elderly or hospitalized patients use dietary protein supplementation to maintain or grow skeletal muscle. It is recognized that high quality protein is needed for muscle accretion, and can be obtained from both animal and plant-based sources. There is interest to understand whether these sources differ in their ability to maintain or stimulate muscle growth and function. In this study, baseline muscle performance was assessed in 50 adult Sprague-Dawley rats after which they were assigned to one of five semi-purified “Western” diets (n = 10/group) differing only in protein source, namely 19 kcal% protein from either milk protein isolate (MPI), whey protein isolate (WPI), soy protein isolate (SPI), soy protein concentrate (SPC) or enzyme-treated soy protein (SPE). The diets were fed for 8 weeks at which point muscle performance testing was repeated and tissues were collected for analysis. There was no significant difference in food consumption or body weights over time between the diet groups nor were there differences in terminal organ and muscle weights or in serum lipids, creatinine or myostatin. Compared with MPI-fed rats, rats fed WPI and SPC displayed a greater maximum rate of contraction using the in vivo measure of muscle performance (p<0.05) with increases ranging from 13.3–27.5% and 22.8–29.5%, respectively at 60, 80, 100 and 150 Hz. When the maximum force was normalized to body weight, SPC-fed rats displayed increased force compared to MPI (p<0.05), whereas when normalized to gastrocnemius weight, WPI-fed rats displayed increased force compared to MPI (p<0.05). There was no difference between groups using in situ muscle performance. In conclusion, soy protein consumption, in high-fat diet, resulted in muscle function comparable to whey protein and improved compared to milk protein. The benefits seen with soy or whey protein were independent of changes in muscle mass or fiber cross-sectional area.

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Effects of dietary soy protein on skeletal muscle volume and strength in humans with various physical activities

Abstract: The supplementation of soy protein would be one of the effective foods which prevent the skeletal muscle atrophy caused by immobilization or unloading.

Cited by 25 publications

References 18 publications

Effects of a High-Protein Diet Including Whole Eggs on Muscle Composition and Indices of Cardiometabolic Health and Systemic Inflammation in Older Adults with Overweight or Obesity: A Randomized Controlled Trial

Effects of a High-Protein Diet Including Whole Eggs on Muscle Composition and Indices of Cardiometabolic Health and Systemic Inflammation in Older Adults with Overweight or Obesity: A Randomized Controlled Trial

Effect of different sources of dietary protein on muscle hypertrophy in functionally overloaded mice

Chronic dietary supplementation with soy protein improves muscle function in rats

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