Effects of dietary soybean lecithin on plasma lipid transport and hepatic cholesterol metabolism in rats

LeBlanc, Marie Josée; Brunet, Sylvain; Bouchard, Guylaine; Lamireau, T.; Yousef, Ibrahim M.; Gavino, Victor C.; Lévy, Émile; Tuchweber, Béatriz

doi:10.1016/s0955-2863(02)00253-x

Cited by 53 publications

(53 citation statements)

References 38 publications

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“…L markedly increased bile flow, and the secretion rate of bile acid, CHOL, and PL in Abcb4ϩ/ϩ mice. This confirms our previous studies in rats in which we also found enhanced bile acid pool size (14). L, however, did not significantly alter the canalicular membrane content of proteins involved in lipid transport to bile (14).…”

Section: Discussionsupporting

confidence: 92%

“…The percentage of triglyceride in both diets was comparable, and the fatty acid composition did not differ significantly between diets. The composition of the C and Lsupplemented diets has been described elsewhere (13,14). The mice were housed under a 12:12-h light-dark cycle and with free access to food and drinking water.…”

Section: Methodsmentioning

confidence: 99%

“…Studies from this laboratory have shown that feeding animals L-enriched diets stimulates bile secretion under the basal condition and after hepatic bile salt loading (13,14). L also limits the development of hepatic fibrosis induced in animals by carbon tetrachloride or alcohol (15,16).…”

mentioning

confidence: 99%

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Dietary Lecithin Protects Against Cholestatic Liver Disease in Cholic Acid–Fed Abcb4− Deficient Mice

et al. 2007

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Mutations in multidrug resistance 3 gene (MDR3 or ABCB4) underlie progressive familial intrahepatic cholestasis type 3 (PFIC3), a severe pediatric liver disease progressing to cirrhosis. Abcb4Ϫ/Ϫ mice exhibit slowly developing hepatic lesions that can be accelerated by feeding a cholic acid (CA)-supplemented diet. We investigated the beneficial effects of a soybean lecithin (L)-supplemented diet in this model of liver disease. Abcb4Ϫ/Ϫ mice and wild-type (WT) controls were divided in four groups by the diet they were fed: control (C) diet, L-supplemented diet, CA-supplemented diet, and L-and CA-supplemented (LϩCA) diet. After 2 wk on these regimens, liver enzymes and bilirubin were measured in serum with bile flow, total bile acids, and cholesterol (CHOL) and phospholipid (PL) concentrations in bile. Ductular hyperplasia, portal fibroblastic cell proliferation, myofibroblast activation, and hepatic fibrosis were quantified on liver sections. Abcb4Ϫ/Ϫ mice fed the C diet exhibited mild liver damage. CA produced very high elevations of serum liver enzymes and bilirubin with significant bile duct proliferation, peribiliary fibroblast activation, and fibrosis. The L-supplemented diet dramatically mitigated the hepatic damage in CA-supplemented diet animals. We conclude that L is protective against liver disease in Abcb4Ϫ/Ϫ mice and suggest that it could offer potential benefit in PFIC3. (Pediatr Res 61: [185][186][187][188][189][190] 2007)

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

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Dietary Lecithin Protects Against Cholestatic Liver Disease in Cholic Acid–Fed Abcb4− Deficient Mice

et al. 2007

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“…A diet enriched with 20% soybean lecithin caused only a 17% increase in hepatic CYP7A1 activity in rats. 32) To our knowledge, the effect of glycolipids on CYP7A1 activity in rats is unknown. Previously, we found that the indigestible fraction of Chlorella had a greater capacity to bind bile acids in vitro than did CP on a dry weight basis.…”

Section: Discussionmentioning

confidence: 99%

Hypocholesterolemic Mechanism ofChlorella:Chlorellaand Its Indigestible Fraction Enhance Hepatic Cholesterol Catabolism through Up-Regulation of Cholesterol 7α-Hydroxylase in Rats

Shibata

Hayakawa

Egashira

et al. 2007

Bioscience, Biotechnology, and Biochemistry

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“…Choline is required for cell signalling and VLDL secretion from hepatocytes (42). Dietary choline as well as phosphatidylcholine has been shown to affect hepatic cholesterol homeostasis in rats, including increased excretion of cholesterol via the bile (43,44). The diets in this study were not supplemented with choline since both beef and fish muscle contain high amounts of total choline (45).…”

Section: Discussionmentioning

confidence: 99%

Dietary herring improves plasma lipid profiles and reduces atherosclerosis in obese low-density lipoprotein receptor-deficient mice

Gabrielsson

Wikström²,

Jakubowicz³

et al. 2011

Int J Mol Med

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Abstract. Diet is a significant modifiable risk factor for cardiovascular disease and high fish intake has been associated with vascular health in population studies. However, intervention studies have been inconclusive. In this study, male low-density lipoprotein receptor-deficient mice were given 16-week high fat/high sucrose diets, supplemented with either minced herring fillets or minced beef. The diets were matched in total fat and cholesterol content; taurine content and fatty acid composition was analysed. Body weights were recorded throughout the study; plasma lipids were analysed at week 8 and 16. Body composition and adipocyte size were evaluated at study end. Atherosclerosis was evaluated at week 12 (ultrasound) and at termination (en face histology). Herring-fed mice had a higher proportion of long-chain n-3 polyunsaturated fatty acids in the hepatic triacylglycerides (TAG) and phospholipid fractions. The herring-fed mice had increased body weight (P= 0.007), and reduced epididymal adipocyte size (P= 0.009), despite similar food intake and body composition as the beef-fed mice. The herring-fed mice had lower plasma TAG and verylow-density lipoprotein (VLDL)-cholesterol concentrations throughout the study (TAG; P= 0.0012 and 0.004, VLDLcholesterol; P=0.006 and 0.041, week 8 and 16, respectively). At week 16, the herring-fed had higher plasma concentrations of HDL-cholesterol (P=0.004) and less atherosclerotic lesions in the aortic arch (P=0.007) compared with the beef-fed mice.In conclusion, dietary herring in comparison to beef markedly improved vascular health in this mouse model, suggesting that herring provides an added value beyond its content of macronutrients.

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Effects of dietary soybean lecithin on plasma lipid transport and hepatic cholesterol metabolism in rats

Cited by 53 publications

References 38 publications

Dietary Lecithin Protects Against Cholestatic Liver Disease in Cholic Acid–Fed Abcb4− Deficient Mice

Dietary Lecithin Protects Against Cholestatic Liver Disease in Cholic Acid–Fed Abcb4− Deficient Mice

Hypocholesterolemic Mechanism ofChlorella:Chlorellaand Its Indigestible Fraction Enhance Hepatic Cholesterol Catabolism through Up-Regulation of Cholesterol 7α-Hydroxylase in Rats

Dietary herring improves plasma lipid profiles and reduces atherosclerosis in obese low-density lipoprotein receptor-deficient mice

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