Effects of dietary supplementation of fish oil plus vitamin D<sub>3</sub> on gut microbiota and fecal metabolites, and their correlation with nonalcoholic fatty liver disease risk factors: a randomized controlled trial

Li, Xueqi; Pan, Chi; Ma, Wenjun; Yang, Ting; Wang, Chong; Han, Weiwei; Zhang, Wei; Li, Hui; Li, Zhongxia; Zhao, Ting; Guo, Xiao-fei; Li, Duo

doi:10.1039/d3fo02319b

Food Funct.

2024

DOI: 10.1039/d3fo02319b

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Effects of dietary supplementation of fish oil plus vitamin D₃ on gut microbiota and fecal metabolites, and their correlation with nonalcoholic fatty liver disease risk factors: a randomized controlled trial

Xueqi Li,

Chi Pan,

Wenjun Ma

et al.

Abstract: We previous reported that fish oil plus vitamin D3 (FO+D) could ameliorate nonalcoholic fatty liver disease (NAFLD). However, it is unclear whether the beneficial effects of FO+D on NAFLD...

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Cited by 2 publications

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Metabolic disorders, inter-organ crosstalk, and inflammation in the progression of metabolic dysfunction-associated steatotic liver disease

Wang,

Yin,

Liu

et al. 2024

Life Sciences

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Metabolic disorders, inter-organ crosstalk, and inflammation in the progression of metabolic dysfunction-associated steatotic liver disease

Wang,

Yin,

Liu

et al. 2024

Life Sciences

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Micronutrient (iron, selenium, vitamin D) supplementation and the gut microbiome

Faradina,

Tinkov,

Skalny

et al. 2024

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review Deficiencies in micronutrients persist as widespread global challenges, where supplementation remains a crucial therapeutic approach. This review aims to elucidate the intricate relationships between micronutrient supplementation – specifically iron, selenium (Se), and vitamin D (Vit D) – and gut microbiota composition, investigating their collective impact on host health and disease susceptibility. Recent findings Maintaining balanced iron levels is essential for gut microbiota equilibrium and host health, as both iron deficiency and excess disrupt gut bacterial balance, affecting colon health. Se supplementation can restore and improve the gut microbial balance, influencing health outcomes not only in the gut but also in areas such as neuroprotection in the brain, testicular health, and metabolic syndrome. Clinical and experimental models demonstrate that Vit D modulates the gut microbiome, enhancing anti-inflammatory effects, supporting metabolic health, and potentially reducing the risk of gut-related behavioral changes and diseases. Summary Findings of this review emphasize that balanced iron levels are essential for maintaining a healthy gut microbiota composition and underscore the beneficial effects of Se and Vit D in modulating the gut microbiome. The interactions between micronutrients and the gut microbiome are complex but may have a broad spectrum of health outcomes.

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Effects of dietary supplementation of fish oil plus vitamin D₃ on gut microbiota and fecal metabolites, and their correlation with nonalcoholic fatty liver disease risk factors: a randomized controlled trial

Abstract: We previous reported that fish oil plus vitamin D3 (FO+D) could ameliorate nonalcoholic fatty liver disease (NAFLD). However, it is unclear whether the beneficial effects of FO+D on NAFLD...

Cited by 2 publications

References 62 publications

Metabolic disorders, inter-organ crosstalk, and inflammation in the progression of metabolic dysfunction-associated steatotic liver disease

Metabolic disorders, inter-organ crosstalk, and inflammation in the progression of metabolic dysfunction-associated steatotic liver disease

Micronutrient (iron, selenium, vitamin D) supplementation and the gut microbiome

Contact Info

Product

Resources

About

Effects of dietary supplementation of fish oil plus vitamin D3 on gut microbiota and fecal metabolites, and their correlation with nonalcoholic fatty liver disease risk factors: a randomized controlled trial

Abstract: We previous reported that fish oil plus vitamin D3 (FO+D) could ameliorate nonalcoholic fatty liver disease (NAFLD). However, it is unclear whether the beneficial effects of FO+D on NAFLD...

Cited by 2 publications

References 62 publications

Metabolic disorders, inter-organ crosstalk, and inflammation in the progression of metabolic dysfunction-associated steatotic liver disease

Metabolic disorders, inter-organ crosstalk, and inflammation in the progression of metabolic dysfunction-associated steatotic liver disease

Micronutrient (iron, selenium, vitamin D) supplementation and the gut microbiome

Contact Info

Product

Resources

About

Effects of dietary supplementation of fish oil plus vitamin D₃ on gut microbiota and fecal metabolites, and their correlation with nonalcoholic fatty liver disease risk factors: a randomized controlled trial