Effects of dietary supplementation of antimicrobial peptide-A3 on growth performance, nutrient digestibility, intestinal and fecal microflora and intestinal morphology in weanling pigs

Yoon, Jonghun; Ingale, S.L.; Kim, J.S.; Kim, K.H.; Lee, S.H.; Park, Y.K.; Kwon, I.K.; Chae, B. J.

doi:10.1016/j.anifeedsci.2012.06.009

Cited by 82 publications

(69 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been well established that antimicrobial feed additives beneficially affect the host animal by improving its intestinal balance (Fuller, 1989) and creating gut micro-ecological conditions that suppress harmful microorganisms like coliforms and by favoring beneficial microorganisms like Lactobacillus spp. (Heyman and Menard, 2002;Choi et al, 2011a;Yoon et al, 2012 and. In the current experiment, bacteriophages had the most notable effects against Clostridium spp.…”

Section: Discussionmentioning

confidence: 85%

“…In recent years, considerable efforts have been made for developing novel non-antibiotic feed additives which have the potential to improve the gut health, immunity and performance of pigs (Jin et al, 2009;Choi et al, 2011b;Yoon et al, 2012 and. Among various alternatives, bacteriophages have received attention due to their natural antimicrobial properties and lower propensity for the development of bacterial resistance (Gebru et al, 2010;Wittebole et al, 2014;Kim et al 2014b).…”

Section: Discussionmentioning

confidence: 99%

“…Small intestinal morphology Three cross-sections for each intestinal sample were prepared after staining with azure A and eosin using standard paraffin embedding procedures (Yoon et al, 2012). A total of ten intact, well-oriented crypt-villus units were selected in triplicate for each intestinal cross-section.…”

Section: Bacteriophagesmentioning

confidence: 99%

“…Therefore, the search continues for non-antibacterial growth promoters that are active in vivo, are fast acting, possess a broad spectrum in activity, do not induce bacterial resistance and subsequently promote growth performance of pigs. A number of research findings on the use of alternatives like probiotics, oligosaccharides, organic acids and antimicrobial peptides to replace antibiotics in feed have been documented with varying success (Kenny et al, 2011;Choi et al, 2011a;Yoon et al, 2012). In this context, bacteriophages are believed to be an ideal candidate, due to their natural antibacterial properties (Jamalludeen et al, 2009;Yan et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Bacteriophage cocktail and multi-strain probiotics in the feed for weanling pigs: effects on intestine morphology and targeted intestinal coliforms and Clostridium

Kim

Hosseindoust

Lee

et al. 2017

Animal

Self Cite

View full text Add to dashboard Cite

Two experiments were conducted to investigate the effects of dietary supplementation of bacteriophage cocktail, probiotics and a combination of these two supplements on performance and gut health of weanling pigs. In Experiment 1, 150 weaned piglets were randomly allotted to three treatments on the basis of BW. The dietary treatments included a basal diet supplemented with 0 (control), 1.0 and 1.5 g/kg bacteriophage cocktail. Pigs fed 1.0 and 1.5 g/kg bacteriophage product had greater (P < 0.05) average daily gain (ADG), apparent total tract digestibility of dry matter from day 22 to 35, ileal Lactobacillus spp., villus height (duodenum and jejunum), and fewer coliforms (ileum) and Clostridium spp. (ileum). In Experiment 2, 200 weaned piglets were randomly allotted to four treatments. Dietary treatments included basal diet, basal diet supplemented with 3.0 g/kg fermented probiotic product (P), 1.0 g/kg bacteriophage cocktail (B) and combination of 1.0 g/kg bacteriophage cocktail and 3.0 g/kg fermented probiotic product. Pigs fed bacteriophage cocktail diets had greater (P < 0.05) overall ADG, gain to feed ratio (G : F), fecal score from day 8 to day 21, and pigs fed bacteriophage cocktail diets had fewer coliforms (ileum) Clostridium spp. (ileum and cecum). Probiotics significantly increased G : F, colonization of Lactobacillus spp. in ileum. At day 35, bacteriophage treatment group showed greater (P < 0.05) villus height of the duodenum, but a deeper crypt in duodenum. The present results indicate that the bacteriophage cocktail had a potential to enhance the performance and gut health of weanling pigs, however their combination with probiotics did not show an interaction.

show abstract

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Bacteriophagesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bacteriophage cocktail and multi-strain probiotics in the feed for weanling pigs: effects on intestine morphology and targeted intestinal coliforms and Clostridium

Kim

Hosseindoust

Lee

et al. 2017

Animal

Self Cite

View full text Add to dashboard Cite

show abstract

“…Enhancing normal gut microflora by targeting intestinal pathogens through non-antibiotic approaches can improve the gut health, immunity, and performance of pigs and poultry (Suryanarayana et al 2012;Yoon et al 2012). Among various non-antibiotic alternatives, OA (Lambert and Stratford 1999;Suryanarayana et al 2012) and zinc sources (Hollis et al 2005) have been used previously.…”

Section: Discussionmentioning

confidence: 99%

Dietary bacteriophages as an alternative for zinc oxide or organic acids to control diarrhoea and improve the performance of weanling piglets

Hosseindoust¹,

Lee²,

Kim³

et al. 2017

Vet. Med.

View full text Add to dashboard Cite

ABSTRACT:In this study, the antibacterial substances ZnO, organic acids and a bacteriophage cocktail were added to the diet of weanling pigs to evaluate the effects on gut health. Dietary treatments were basal diet without any supplementation (Control) and basal diet either supplemented with 0.34% (2500 ppm) ZnO, 0.20% organic acids or with 0.10% bacteriophage cocktail. Faecal score was decreased in ZnO and bacteriophage cocktail treatments. The total number of ileal anaerobic bacteria, Bifidobacterium spp. and Lactobacillus spp. were higher in ZnO, bacteriophage cocktail and organic acids, while ileal coliforms and caecal Clostridium spp. were decreased in comparison to Control. Faecal coliforms (Day 7 and Day 21) and Clostridium spp. (Day 21 and Day 35) were lower in bacteriophage cocktail. The gain to feed ratio was improved in all supplemented groups. The digestibility of dry matter was increased at the end of the experiment in all supplemented groups, while that of crude protein was increased only at Day 21 in bacteriophage cocktail. Duodenal villus height was increased in ZnO and bacteriophage cocktail. Bacteriophage cocktail also showed a greater villus height in the small intestine. Supplementation of bacteriophage cocktail in weaning pig diets resulted in better growth performance, digestibility and gut development compared to Control, and thus, it can be concluded that its effects are comparable to ZnO or organic acids supplementation.

show abstract

Food Preservatives From Microbial Origin: Industrial Perspectives

Lakshmayya

Lekhya

Mohanta

et al. 2022

Role of Microbes in Industrial Products and Processes

View full text Add to dashboard Cite

Effects of dietary supplementation of antimicrobial peptide-A3 on growth performance, nutrient digestibility, intestinal and fecal microflora and intestinal morphology in weanling pigs

Cited by 82 publications

References 34 publications

Bacteriophage cocktail and multi-strain probiotics in the feed for weanling pigs: effects on intestine morphology and targeted intestinal coliforms and Clostridium

Bacteriophage cocktail and multi-strain probiotics in the feed for weanling pigs: effects on intestine morphology and targeted intestinal coliforms and Clostridium

Dietary bacteriophages as an alternative for zinc oxide or organic acids to control diarrhoea and improve the performance of weanling piglets

Food Preservatives From Microbial Origin: Industrial Perspectives

Contact Info

Product

Resources

About