Effects of dietary supplementation with essential oils and organic acids on the growth performance, immune system, fecal volatile fatty acids, and microflora community in weaned piglets

Yang, Caimei; Zhang, Lingling; Cao, Guangtian; Feng, Jie; Yue, Min; Xu, Yinglei; Dai, Bin; Han, Qianjie; Guo, Xiqin

doi:10.1093/jas/sky426

Cited by 74 publications

(61 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, the Firmicutes level was increased and the Proteobacteria level was decreased. Earlier studies have shown that Firmicutes, Bacteroidetes and Proteobacteria were the most dominant phyla in pigs [53][54] which was similar with our study. At the genus level, we observed that the Escherichia was signi cantly decreased.…”

Section: Discussionsupporting

confidence: 93%

Effect of dietary pyrroloquinoline quinone disodium in sows on intestinal health of the offspring

Wang

Zhang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Pyrroloquinoline quinone (PQQ) is a putative essential nutrient and redox modulator in microorganisms, cell and animal models. The objective of this study was to investigate the effects of pyrroloquinoline quinone disodium (PQQ·Na2) in sows during gestation and lactation on intestinal health in the offspring.Results: The activities of SOD and GSH-Px were significantly (P<0.05) increased by PQQ·Na2 supplementation, and MDA activity was decreased (P<0.05) in the plasma of piglets. CAT, SOD and GSH-Px activities were significantly (P<0.05) increased, and MDA activity was decreased (P<0.05) in the small intestine of piglets. The mRNA expression levels of SOD1, CAT and MGST1 in the jejunum were increased in newborn piglets (P<0.05), and the mRNA expression levels of HO1, SOD1, CAT, SOD2, GPX4, GPX1 and GCLC in the jejunum were increased in weaned piglets (P<0.05). The mRNA expression of ZO-1 was increased (P<0.05) in the jejunum of newborn piglets, and the mRNA expression of Occludin and ZO-1 was increased (P<0.05) in the jejunum of weaned piglets. The villous height of the duodenum and jejunum of weaned piglets was increased (P<0.05) by dietary PQQ·Na2. In weaned piglets, Bacteroidetes and Firmicutes were the most prevalent phyla in both the Con and PQQ·Na2 treatment groups, and the most prevalent genera were Alloprevotella and Bacteroides. At the phylum level, the abundance of Firmicutes was significantly increased (P<0.05), and the abundance of Proteobacteria was significantly decreased (P<0.05). At the genus level, the abundance of Alloprevotella was significantly increased (P<0.05), and the abundance of Actinobacillus and Escherichia was decreased (P<0.05).Conclusions: In conclusion, dietary supplementation with PQQ·Na2 in sows during gestation and lactation had positive effects on intestinal health in offspring.

show abstract

Section: Discussionsupporting

confidence: 93%

Effect of dietary pyrroloquinoline quinone disodium in sows on intestinal health of the offspring

Wang

Zhang

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…In pig farming, the weaning phase is characterized by high levels of stress resulting in decreased feed intake, growth retardation and a higher tendency to develop gastrointestinal diseases [1,2] that may require the use of antimicrobial compounds. Thus, alternatives include the use of feed supplements able to improve general health status by modulating the digestive process and the intestinal microbiota, such as probiotics, prebiotics and organic acids [3][4][5]. In light of this, short chain fatty acids (SCFA) play a fundamental role in modulating the intestinal microbial population and in promoting the digestion phase [6].…”

Section: Introductionmentioning

confidence: 99%

Effects of Tributyrin Supplementation on Growth Performance, Insulin, Blood Metabolites and Gut Microbiota in Weaned Piglets

Sotira

Dell’Anno

Caprarulo

et al. 2020

Animals

View full text Add to dashboard Cite

The aim of this study was to investigate the effects of tributyrin supplementation on the production traits, the main metabolic parameters and gut microbiota in weaned piglets. One hundred and twenty crossbred piglets (Large White × Landrace) were randomly divided into two experimental groups (six pens each; 10 piglets per pen): the control group (CTRL), that received a basal diet, and the tributyrin group (TRIB) that received the basal diet supplemented with 0.2% tributyrin. The experimental period lasted 40 days. Production traits were measured at days 14, 28 and 40. A subset composed of 48 animals (n = 4 for each pen; n = 24 per group) was considered for the evaluation of serum metabolic parameters and hair cortisol by enzyme-linked immunosorbent assay (ELISA), and faecal microbiota by real-time polymerase chain reaction (PCR). Our results showed that the treatment significantly increased body weight (BW) at day 28 and day 40 (p = 0.0279 and p = 0.0006, respectively) and average daily gain (ADG) from day 28 to day 40 (p = 0.046). Gain to feed ratio (G:F) was significantly higher throughout the experimental period (p = 0.049). Even if the serum parameters were in the physiological range, albumin, albumin/globulin (A/G) ratio, glucose and high-density lipoproteins (HDL) fraction were significantly higher in the TRIB group. On the contrary, tributyrin significantly decreased the urea blood concentration (p = 0.0026), which was correlated with lean gain and feed efficiency. Moreover, serum insulin concentration, which has a regulatory effect on protein and lipid metabolism, was significantly higher in the TRIB group (p = 0.0187). In conclusion, this study demonstrated that tributyrin can be considered as a valid feed additive for weaned piglets.

show abstract

“…The main mode of action of OA is the ability to penetrate bacterial cells when they are non-dissociated, which could disrupt the normal physiology of certain types of bacteria ( Khan and Iqbal, 2015 ). Essential oils (EO), natural bioactive compounds derived from plants, were studied recently and considered as an effective additive in improving animal growth, immune system and modulating intestinal health as well as diarrhea ( Yang et al., 2019 ). The antimicrobial activity of EO has been extensively tested in vitro against a wide range of pathogenic bacteria, therefore it could be considered as one of the alternatives in maintaining the balance of microbiota ( Kalemba and Kunicka, 2003 ; Ouwehand et al., 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Micro-encapsulated essential oils and organic acids combination improves intestinal barrier function, inflammatory responses and microbiota of weaned piglets challenged with enterotoxigenic Escherichia coli F4 (K88+)

Lahaye²,

et al. 2020

Animal Nutrition

View full text Add to dashboard Cite

This study evaluated the effects of micro-encapsulated (protected) organic acids (OA) and essential oils (EO) combination, P(OA + EO), and effects of a regular blend of free acids (FA) on the growth, immune responses, intestinal barrier and microbiota of weaned piglets challenged with enterotoxigenic Escherichia coli (ETEC) F4 (K88 + ). A total of 30 crossbred (Duroc × Landrace × Large White) weaned barrows (7.41 ± 0.06 kg, 28 d old) were assigned randomly to 5 treatments: 1) non-challenged positive control (PC), 2) ETEC F4 (K88 + )-challenged negative control (NC), 3) NC + kitasamycin at 50 mg/kg + olaquindox at 100 mg/kg + free acidifier (FA) at 5 g/kg, 4) NC + kitasamycin at 50 mg/kg + olaquindox at 100 mg/kg + P(OA + EO) at 1 g/kg (P1), 5) NC + kitasamycin at 50 mg/kg + olaquindox at 100 mg/kg + P(OA + EO) at 2 g/kg (P2). Each dietary treatment had 6 replicates of one piglet each and the study lasted for 3 wk. On d 7, pigs in NC, FA, P1 and P2 were orally dosed with 10 mL of ETEC F4 (K88 + ) culture (1 × 10 9 CFU/mL). From d 7 to 14 after the ETEC F4 (K88 + ) challenge, P1 increased gain-to-feed ratio (G:F) significantly ( P < 0.05) compared with NC and FA groups. From d 14 to 21, P2 increased the average daily gain of pigs ( P < 0.05) compared with NC and FA groups. Compared with NC, P2 reduced tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-10 concentrations ( P < 0.05) in sera collected at 4 h later after ETEC F4 (K88 + ) challenge. On d 21, P1 increased occludin and zonula occludens-1 protein expression in ileum compared with NC ( P < 0.05). After this 3-wk experiment, alpha diversity of gut microbiota was decreased by P2 compared with PC, and P1 increased the relative abundance of Lactobacillus in ileum, cecum and colon ( P < 0.05). In conclusion, dietary P(OA + EO) additive at 2 g/kg combined with antibiotics could improve piglet performance and attenuate inflammation, and P(OA + EO) additive at 1 g/kg combined with antibiotics improved intestinal barrier and increased beneficial microbiota composition after an F4 (K88 + ) challenge.

show abstract

Effects of dietary supplementation with essential oils and organic acids on the growth performance, immune system, fecal volatile fatty acids, and microflora community in weaned piglets

Cited by 74 publications

References 44 publications

Effect of dietary pyrroloquinoline quinone disodium in sows on intestinal health of the offspring

Effect of dietary pyrroloquinoline quinone disodium in sows on intestinal health of the offspring

Effects of Tributyrin Supplementation on Growth Performance, Insulin, Blood Metabolites and Gut Microbiota in Weaned Piglets

Micro-encapsulated essential oils and organic acids combination improves intestinal barrier function, inflammatory responses and microbiota of weaned piglets challenged with enterotoxigenic Escherichia coli F4 (K88+)

Contact Info

Product

Resources

About