Effects of dietary supplementation with yeast glycoprotein on growth performance, intestinal mucosal morphology, immune response and colonic microbiota in weaned piglets

Huang, Feiruo; Ji, Wei; Wang, Jianlin; Li, Biao; Hu, Junpeng; Wu, Xin

doi:10.1039/c8fo02327a

Cited by 46 publications

(38 citation statements)

References 46 publications

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“…It has reported that weaning stress could cause intestinal injury with the reduced intestinal villi height, the deepened recess, the changes of intestinal morphology from dense and finger-like villi to smooth and tongue-like villi, and the reduced active absorption capacity of the small intestine [5]. Normal intestinal function depends on the local barrier, which prevents the translocation of bacteria and endotoxins contained within the intestinal lumen to extraintestinal sites, and largely prevents the occurrence of diarrhea [34]. Intestinal mucosa permeability is the principal basis for the diagnosis of the intestinal barrier dysfunction [34].…”

Section: Discussionmentioning

confidence: 99%

“…Normal intestinal function depends on the local barrier, which prevents the translocation of bacteria and endotoxins contained within the intestinal lumen to extraintestinal sites, and largely prevents the occurrence of diarrhea [34]. Intestinal mucosa permeability is the principal basis for the diagnosis of the intestinal barrier dysfunction [34]. Serum D-lactate and DAO can be used as indicators of intestinal integrity of the gastrointestinal tract [35].…”

Section: Discussionmentioning

confidence: 99%

“…The large intestine supports a dynamic microenvironment that varies with age and environmental factors [34]. Any alteration in the physical or chemical properties of colonic contents has the potential to impact the resident bacterial population and potentially favor or inhibit the establishment of pathogenic species.…”

Section: Discussionmentioning

confidence: 99%

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RETRACTED ARTICLE: Dietary garcinol supplementation improves diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets

Wang

Yao

et al. 2020

J Animal Sci Biotechnol

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Background: The effects of dietary garcinol on diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets were investigated. Method: One hundred forty four weaned piglets (Duroc × Yorkshire × Landrace) from 16 pens (9 piglets per pen) were randomly divided into four treatment groups: controls (CON) or those supplemented with 200 mg/kg (LOW), 400 mg/kg (MID), or 600 mg/kg (HIGH) diet garcinol. After 14-day trial, three piglets per pen were chosen to collect plasma, intestinal tissue and colonic digesta samples. Results: We demonstrated for the first time that garcinol promoted growth performance, as increased average daily feed intake (ADFI) and decreased feed/gain ratio (F/G); and reduced diarrhea incidence (P < 0.05); and strengthened antioxidant capacity, as an increased antioxidative index (P < 0.05). Additionally, garcinol ameliorated intestinal barrier dysfunction, as an increased villus height to crypt depth ratio, increased zonula occludens protein 1 (ZO-1), occludin and claudin-1 expression in the jejunum and ileum (P < 0.05), and decreased intestinal permeability (P < 0.05); and reduced inflammation, as decreased cytokine interleukin (IL)-6, IL-10, IL-1β and tumor necrosis factor-α (TNF-α) levels in the mucosa of the jejunum and ileum, and NF-κB p65 translocation (P < 0.05). Moreover, garcinol inhibited the growth of most harmful bacteria in the gut, especially Escherichia coli, and increased the growth of the beneficial bacteria Lactobacillus. Conclusion: This work provides a fundamental basis for the future development of garcinol-functional food use for improving diarrhea and intestinal barrier function in weaned piglets and for understanding the biological effects of garcinol and its potential as a functional feed additive.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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RETRACTED ARTICLE: Dietary garcinol supplementation improves diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets

Wang

Yao

et al. 2020

J Animal Sci Biotechnol

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“…The blood samples were collected from the jugular vein into two tubes (heparinized tubes and non-heparinized tubes) from fasted piglets at the end of the trial [13]. The blood samples were then centrifuged at 3000 g for 15 min.…”

Section: Methodsmentioning

confidence: 99%

Short-Term Oral UMP/UR Administration Regulates Lipid Metabolism in Early-Weaned Piglets

Zhang

Guo

Xie

et al. 2019

Animals

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Simple SummaryUridine monophosphate (UMP) and uridine (UR) are rich in sow’s milk. The results from this study showed that UMP and UR affect the lipid profile and lipid metabolism in weanling piglets. It is suggested that UMP and UR improve the energy status in early-weaned piglets.AbstractAs a main ingredient of milk, the nucleotides content is about 12–58 mg/g, which plays a critical role in maintaining cellular function and lipid metabolism. This study was conducted to evaluate the effects of short-term uridine monophosphate (UMP) and uridine (UR) administration on lipid metabolism in early-weaned piglets. Twenty-one weaned piglets (7 d of age; 3.32 ± 0.20 kg average body weight) were randomly assigned into three groups: The control (CON), UMP, and UR group, and oral administered UMP or UR for 10 days, respectively. The results showed that supplementation with UMP significantly increased (p < 0.05) serum low density lipoprotein (LDL) and tended to increase (p = 0.062) serum total cholesterol (TC) content of piglets when compared with the other two groups. Oral administration with UMP and UR significantly decreased (p < 0.05) the serum total bile acid (TBA) and plasma free fatty acids (FFA) of piglets, and significantly reduced the fatty acid content of C12:0 (p < 0.01) and C14:0 (p < 0.05) in liver. Experiments about key enzymes that are involved in de novo synthesis of fatty acid showed that the gene expression of liver X receptors (LXRα), sterol regulatory element-binding transcription factor 1 (SREBP1c), fatty acid desaturase 2 (FADS2), and fatty acid elongase 5 (ELOVL5) were remarkably down-regulated (p < 0.05) with UMP and UR treatment, and key factors of adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and carnitine palmitoyl transferase 1 (CPT-1α) involved in fatty acid catabolism were also decreased (p < 0.05). Additionally, the protein expression of phosphorylated-mTOR was not affected while phosphorylation of AKT was repressed (p < 0.05). In conclusion, short-term oral UMP or UR administration could regulate fatty acid composition and lipid metabolism, thus providing energy for early-weaned piglets.

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“…Os efeitos da suplementação alimentar com glicoproteína de levedura (800 mg/kg da ração), foram avaliados no desempenho e resposta imune a nível de microbiota intestinal na dieta de 240 leitões desmamados em média com 23 dias. Os animais alimentados com a glicoproteína de levedura apresentaram maior peso corporal final, aumento no ganho médio diário de peso e melhor conversão alimentar, além de proporcionarem melhor desenvolvimento intestinal, melhorando a saúde de leitões desmamados (Qin, et al, 2019).…”

Section: Levedurasunclassified

Uso de aditivos em dietas para leitões em fase de creche: uma revisão

Lima

Lopes

Silva

et al. 2020

RSD

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O uso de aditivos em dietas para leitões desmamados na suinocultura industrial tem como intuito diminuir o uso de antimicrobianos na produção suinícola, além de melhorar a saúde intestinal e desempenho produtivo dos animais. Portanto, neste estudo teve-se como objetivo elaborar uma revisão bibliográfica sobre os principais aditivos utilizados em dietas para leitões na fase de creche. Os aditivos atuam como probióticos e prebióticos, sendo estes essenciais na fase de creche devido aos desafios sanitários que os animais são submetidos, visto que promovem benefícios para a saúde dos animais. O sucesso na utilização dos aditivos na fase de creche está relacionado com a dosagem a ser utilizada e principalmente com o nível de desafio sanitário ao qual os animais são expostos. Alguns resultados de pesquisas nessa área indicam que os aditivos são mais eficientes em animais mais desafiados, o que justifica a variabilidade de resultados encontrados na literatura. Alguns estudos demonstram que o mecanismo de ação dos aditivos pode reduzir o uso de antimicrobianos nas dietas de leitões em fase de creche, além de agregar melhores resultados de desempenho zootécnico. De acordo com a revisão realizada, conclui-se que a utilização de aditivos em dietas de leitões em período de creche, pode garantir melhores índices produtivos dos animais, além de se apresentarem como boas alternativas frente ao uso de antibióticos.

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Effects of dietary supplementation with yeast glycoprotein on growth performance, intestinal mucosal morphology, immune response and colonic microbiota in weaned piglets

Abstract: Antibiotics are commonly provided to weaned piglets; however, this practice has become controversial due to the increased occurrences of microbial resistance, and alternatives are needed.

Cited by 46 publications

References 46 publications

RETRACTED ARTICLE: Dietary garcinol supplementation improves diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets

RETRACTED ARTICLE: Dietary garcinol supplementation improves diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets

Short-Term Oral UMP/UR Administration Regulates Lipid Metabolism in Early-Weaned Piglets

Uso de aditivos em dietas para leitões em fase de creche: uma revisão

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