Effects of Dietary Supplements on the Bioaccessibility of Se, Zn and Cd in Rice: Preliminary Observations from In Vitro Gastrointestinal Simulation Tests

Zhang, Ru; Li, Yonghua; Xu, Yuefeng; Zang, Zhenfeng; Li, Hairong; Wang, Li

doi:10.3390/ijerph17144978

Cited by 9 publications

(2 citation statements)

References 45 publications

(49 reference statements)

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“…Zn bioaccessibility refers to the fraction of soluble Zn in the digestion that was released from the rice grain. Zn bioaccessibility has been shown to be affected by Zn speciation, the digestion phase and various dietary components (Zhang et al 2020). The higher amount of bioaccessible Zn in progenies with high Zn density indicated that total Zn content had a positive effect on Zn bioaccessibility (Table 4).…”

Section: Discussionmentioning

confidence: 99%

Combination of High Zn Density and Low Phytic Acid for Improving Zn Bioavailability in Rice (Oryza stavia L.) Grain

Wang

Meng

et al. 2021

Rice

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Background Zn deficiency is one of the leading public health problems in the world. Staple food crop, such as rice, cannot provide enough Zn to meet the daily dietary requirement because Zn in grain would chelate with phytic acid, which resulted in low Zn bioavailability. Breeding new rice varieties with high Zn bioavailability will be an effective, economic and sustainable strategy to alleviate human Zn deficiency. Results The high Zn density mutant LLZ was crossed with the low phytic acid mutant Os-lpa-XS110–1, and the contents of Zn and phytic acid in the brown rice were determined for the resulting progenies grown at different sites. Among the hybrid progenies, the double mutant always displayed significantly higher Zn content and lower phytic acid content in grain, leading to the lowest molar ratio of phytic acid to Zn under all environments. As assessed by in vitro digestion/Caco-2 cell model, the double mutant contained the relatively high content of bioavailable Zn in brown rice. Conclusions Our findings suggested pyramiding breeding by a combination of high Zn density and low phytic acid is a practical and useful approach to improve Zn bioavailability in rice grain.

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Section: Discussionmentioning

confidence: 99%

Combination of High Zn Density and Low Phytic Acid for Improving Zn Bioavailability in Rice (Oryza stavia L.) Grain

Wang

Meng

et al. 2021

Rice

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“…43 The thiol group of Cys is a preferential metal-binding site considered to be largely implicated in its complexation with metals. 30 Zhang et al 45 reported that the addition of Met increased Cd bioaccessibility in rice in the intestinal phase. Vadas and Ahne 46 found that Cys could effectively solubilize Cd and Pb from contaminated soils because of its ability to form stable complexes with metals through its thiol ligand.…”

Section: Concentrations Of Met and Cys In Wheatmentioning

confidence: 99%

Variations in Cadmium and Lead Bioaccessibility in Wheat Cultivars and Their Correlations with Nutrient Components

Liu,

Xu,

Wang

et al. 2024

J. Agric. Food Chem.

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To reduce the health risks of exposure to Cd and Pb in wheat, a field experiment was conducted to investigate the differences in Cd and Pb bioaccessibility among the grains of 11 wheat cultivars and their relationships with the nutrient compositions of grains. The grain concentrations (Cd: 0.14–0.56 mg kg–1, Pb: 0.08–0.39 mg kg–1) and bioaccessibility (5.28–57.43% and 0.72–7.72% for Cd and Pb in the intestinal phase, respectively) of Cd and Pb differed significantly among the 11 cultivars. A safe wheat cultivar (Shannong16) with a relatively low health risk and the lowest grain Cd and Pb concentrations was selected. Ca, Mg, phytate, and methionine played key roles in affecting Cd and Pb bioaccessibility in wheat, with Ca and phytate significantly negatively correlated with Cd and Pb bioaccessibility. These findings can be used to optimize the selection strategy for safe wheat cultivars for healthy grain production in Cd-polluted farmland.

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Association of multiple trace metals in scalp hair with glioma risk: the mediating role of inflammation

Yan,

You,

Wang

et al. 2024

Ann Clin Transl Neurol

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ObjectiveTo explore the relationship between 35 trace metals in scalp hair and the glioma risk as well as the potential mediating roles of 27 plasma inflammatory cytokines.MethodsA case–control study involving 228 participants was performed in southeastern China. Trace metals in scalp hair were analyzed using inductively coupled plasma mass spectrometry, and multiplex cytokines were detected based on Luminex® technology. The least absolute shrinkage and selection operator (LASSO) regression in combination with four machine learning methods were used to select trace metals associated with gliomas. The joint exposure effect of trace metals was estimated using the generalized weighted quantile sum (gWQS) regression and quantile‐based g‐computation (qgcomp) algorithms.ResultsBoth LASSO regression and random forest algorithms identified five trace metals (gadolinium [Gd], lithium [Li], thulium [Tm], thorium [Th], and molybdenum [Mo]) associated with gliomas. After adjustments for potential confounders, Gd (odds ratio [OR] = 2.84, 95% confidence interval [CI]: 1.89–4.43) and Li (OR = 1.77, 95% CI: 1.04–3.02) concentrations were positively associated with glioma risk, while Tm (OR = 0.36, 95% CI: 0.17–0.73) and Th (OR = 0.45, 95% CI: 0.28–0.71) exhibited inverse associations. Both gWQS and qgcomp algorithms showed Gd contributed most to the mixture effect. Moreover, there was a significant interaction between Gd and Tm or Th on glioma risk (p < 0.05). Notably, granulocyte–macrophage colony‐stimulating factor (GM‐CSF) mediated the association between Gd exposure and glioma risk by 25.75%.InterpretationThese findings suggest potential associations of certain trace metals, especially for Gd, with glioma risk, and may provide new insights into the mechanisms underlying from an inflammatory response perspective.

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Effects of Dietary Supplements on the Bioaccessibility of Se, Zn and Cd in Rice: Preliminary Observations from In Vitro Gastrointestinal Simulation Tests

Cited by 9 publications

References 45 publications

Combination of High Zn Density and Low Phytic Acid for Improving Zn Bioavailability in Rice (Oryza stavia L.) Grain

Combination of High Zn Density and Low Phytic Acid for Improving Zn Bioavailability in Rice (Oryza stavia L.) Grain

Variations in Cadmium and Lead Bioaccessibility in Wheat Cultivars and Their Correlations with Nutrient Components

Association of multiple trace metals in scalp hair with glioma risk: the mediating role of inflammation

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