Effects of Diethylstilbestrol, Zeranol and Sex on Live, Blood Metabolite, Carcass and Endocrine Characteristics of Lambs

Wiggins, J. P.; Wilson, L. L.; Rothenbacher, H; Davis, Steven

doi:10.2527/jas1976.432518x

Cited by 29 publications

(18 citation statements)

References 18 publications

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“…Presumably, zeranol and estradiol exert their effects through common mechanisms that involve interaction between zeranol and estradiol and estrogen receptors within the hypothalamus and pituitary. The combination of direct tissue interactions and secondary effects produced through altered LH and FSH secretion was evident in histochemical changes in primary and secondary sex structures of rams and wethers implanted with zeranol or diethylstilbestrol (Rothenbacher et al, 1975;Wiggins et al, 1976). Data in this study refine, confirm and extend our understanding of the estrogenlike feedback effects of zeranol on the hypothalamo-hypophyseal unit, which controls the secretion of LH, FSH and PRL.…”

Section: Discussionsupporting

confidence: 70%

Luteinizing Hormone, Follicle Stimulating Hormone ad Prolactin Secretion in Ewes and Wethers after Zeranol or Estradiol Injection

Elsasser

Bolt

Bradley

et al. 1983

Journal of Animal Science

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Plasma concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (PRL) were determined over a 24-h period using radioimmunoassay in sheep injected with corn oil (control) or various doses of zeranol or estradiol-17 beta. Injection of .333, 1 or 10 mg of zeranol caused dose-related increases (P less than .01) in plasma PRL (peak levels at 12 to 18 h) and LH (peak levels at 12 to 20 h) in ovariectomized ewes. Similarly, PRL and LH increased following doses of 33 or 100 microgram of estradiol. Before the LH surge, plasma LH levels were significantly depressed (4 to 8 h). Plasma FSH levels were significantly decreased 4 to 8 h after zeranol and estradiol injection. Slight surges of FSH were observed at times similar to those of LH, but the peak level was never greater than control levels. Injection of 1 mg of zeranol or 100 microgram of estradiol into wethers resulted in a 24-h pattern of PRL secretion not significantly different of LH concentration and significantly prolonged inhibition of FSH secretion. These results indicate similarities in the effects of zeranol and estradiol on anterior pituitary hormone secretion within groups of animals of the same sex or reproductive state. Differences in secretion and plasma concentrations of LH, FSH and PRL due to underlying sexual dimorphism are maintained and expressed even when animals are challenged with structurally different compounds of varying estrogenic potencies.

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Section: Discussionsupporting

confidence: 70%

Luteinizing Hormone, Follicle Stimulating Hormone ad Prolactin Secretion in Ewes and Wethers after Zeranol or Estradiol Injection

Elsasser

Bolt

Bradley

et al. 1983

Journal of Animal Science

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“…This occurs when anabolic agents, such as trenbolone acetate (TBA), oestradiol and zeranol, are used to increase growth. Oestradiol and zeranol have oestrogenic activity (Katzenellenbogen et al, 1979), TBA has both androgenic and antioestrogenic activity (Neumann, 1976) and all three compounds inhibit pituitary LH secretion (Wiggins et al, 1976;Gettys et al, 1984;Cooper, 1985). However, to date the effects of these compounds on reproduction in heifers have not been subjected to a comprehensive study.…”

Section: Introductionmentioning

confidence: 99%

Effects of oestradiol, zeranol or trenbolone acetate implants on puberty, reproduction and fertility in heifers

Morán¹,

Prendiville²,

Quirke³

et al. 1990

Reproduction

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Summary. The effects of anabolic agents on reproduction in beef heifers were determined by using 300 mg trenbolone acetate (TBA), 36 = 43\m=.\8and 39\m=.\4for age and weight respectively]. Heifers in Group 4 were older (P < 0\m=.\05), but not heavier (P > 0\m=.\05), while those in Groups 2 and 5 were both older (P < 0\m=.\005) and heavier (P < 0\m=.\005) than the controls at puberty. Age and weight at puberty were not different in heifers assigned to Groups 3 and 4, or to Groups 2 and 6. The proportion of heifers showing oestrus before puberty (prepubertal oestrus) were 3/15, 12/15, 6/12, 7/15, 10/13 and 11/11 in Groups 1\p=n-\6 respectively. Heifers in Groups 2 and 5 had higher incidences of prepubertal oestrus than controls, while those in other treatment groups were not different. There was no treatment effect on the incidence of silent ovulations, but the incidence of non\x=req-\ ovulatory oestrus, after puberty, was increased from 4/48 in Group 1 to 26/40 (P < 0\m=.\001),15/56 (P < 0\m=.\05) and 34/57 (P < 0\m=.\001) in Groups 2, 4 and 5, respectively. Heifers in Group 6 had a higher incidence of non-ovulatory oestrus (P < 0\m=.\05), but not of prepubertal oestrus, than did those in Group 2. The uteri of heifers in Groups 2 and 5 were lighter (P < 0\m=.\05) than those of controls, while the uteri and ovaries of Group 6 heifers were lighter (P < 0\m=.\05) than those of Group 2 heifers. Heifers in Group 3 had lighter ovaries than heifers in Group 4 (P < 0\m=.\05). It is concluded that anabolic agents delayed puberty, increased the incidence of non-ovulatory oestrus and retarded reproductive tract development when given to beef heifers from 84 days of age onwards.

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“…Mating occurred with about 50% of the female mice diagnosed as having a uterine plug. Land (1976) found that when ewes were injected with 37 pg estradiol, has been shown to reduce LH levels in blood of lambs (Wiggins et al, 1976).…”

Section: Des Studiesmentioning

confidence: 98%

Fertility of female mice fed coumestrol and diethylstilbestrol

Elias

Kincaid

1984

Journal of Environmental Science and Health, Part B

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Coumestrol, a compound produced by various legumes which exerts estrogen-like activity in animals, and diethylstilbestrol (DES) were studied as chemical agents for controlling reproduction in mice. Female mice were fed control diets or diets containing 100 ppm coumestrol for eight days. Female mice were exposed to males and reproductive tracts examined 14 days later. Litter size was not affected by 100 ppm dietary coumestrol but feed consumption was reduced 17%. Similar trials were conducted with mice fed 1 ppm DES. Vaginal plugs were present in 50% of the females fed 1 ppm DES, but no fetal pups were present. Feed intake was reduced 37% by the DES. Levels of 0, .1, .25, .50, .75 and 1.0 ppm DES were compared in two strains of mice, Swiss and ICR. Reproduction in both strains was totally inhibited by all DES treatments. The use of DES to control rodent populations warrants further investigation.

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Effects of Diethylstilbestrol, Zeranol and Sex on Live, Blood Metabolite, Carcass and Endocrine Characteristics of Lambs

Cited by 29 publications

References 18 publications

Luteinizing Hormone, Follicle Stimulating Hormone ad Prolactin Secretion in Ewes and Wethers after Zeranol or Estradiol Injection

Luteinizing Hormone, Follicle Stimulating Hormone ad Prolactin Secretion in Ewes and Wethers after Zeranol or Estradiol Injection

Effects of oestradiol, zeranol or trenbolone acetate implants on puberty, reproduction and fertility in heifers

Fertility of female mice fed coumestrol and diethylstilbestrol

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