Effects of different anesthetic approaches on postoperative complications in HIV-infected patients

Abstract

ABSTRACT. The aim of this study was to investigate the effects of three different methods of anesthesia on patients with human immunodeficiency virus (HIV) infection, which could lead to an improvement in postoperative outcomes in these patients. A total of 90 patients undergoing an operation while being treated for an HIV infection were included in this study. Patients were divided into three groups (N = 30/group) based on the type of anesthesia administered: general anesthesia, local anesthesia, and combined spinal epidural anesthesia (CSEA). The effects of local infiltration of anesthesia and peripheral nerve block local anesthesia were examined in the local anesthesia group. The CSEA group examined the effects of spinal anesthesia in HIV-infected patients. We compared the vital (2015) signs of the three groups during the preoperative period, at incision, and during the postoperative recovery period. The CSEA group had a significantly higher mean preoperative CD4 + T lymphocyte count compared with the general anesthesia and local anesthesia groups (P < 0.05). We found that the three kinds of anesthesia methods administered to HIV-infected patients could be used with considerable safety and can be selected according to the clinical need and type of surgical procedure.

The consensus guideline of perioperative antiviral therapy for AIDS patients in China based on clinical practice

“…For instance, acute CMV infection, mycobacterial infections, and Kaposi’s sarcoma can all result in acute appendicitis ( 14 ). Opportunistic infections can also augment surgical risk; for example, pneumocystis and CMV infections increase the risk of cardiovascular disease ( 15 ). Tuberculosis and syphilis can elevate serum HIV load, accelerating disease progression after HIV infection and increasing the risk of transmission ( 16 ).…”