Effects of different anesthetic methods on immune function and oxidative stress in patients undergoing laparoscopic herniorrhaphy.

Abstract

Introduction The influence of anesthetic method on the immune function and oxidative stress in patients receiving laparoscopic herniorrhaphy remains largely unknown. Aim To assess the effects of different anesthetic methods on the immune function and oxidative stress in patients undergoing laparoscopic herniorrhaphy. Material and methods A total of 280 eligible patients were randomly divided into two groups to receive total intravenous anesthesia (TIVA group) and inhalation anesthesia (IA group). T lymphocyte subsets, oxidative stress response indices and inflammatory factor levels were measured before anesthesia, at the end of the operation, and 1 and 3 days after the operation. The incidence rates of adverse reactions were compared. Results At the end of and 1 day after the operation, CD3 + and CD4 + T cells and CD4 + /CD8 + decreased in both groups compared with those before anesthesia (p < 0.05). Three days after the operation, CD3 + and CD4 + T cells decreased in both groups compared with those before anesthesia, which were higher in the TIVA group (p < 0.05). Interleukin-6 and C-reactive protein levels were significantly lower in the TIVA group (p < 0.05). At the end of and 1 and 3 days after the operation, oxidative stress response indices superoxide dismutase, catalase and glutathione peroxidase declined in both groups compared with those before anesthesia, which were higher in the IA group (p < 0.05). The incidence rate of adverse reactions was significantly higher in the IA group (p = 0.002). Conclusions Compared with IA, TIVA has less effect on the immune function and oxidative stress of patients undergoing laparoscopic herniorrhaphy, and controls the inflammatory response more effectively, accompanied by a lower incidence rate of adverse reactions.

Anesthesia-related postoperative oncological surgical outcomes: a comparison of total intravenous anesthesia and volatile anesthesia. A meta-analysis.

“…Similar favorable long-term outcomes with propofol-TIVA have also been found in patients undergoing gastrectomy and colectomy in the studies of Zeng et al (2018) [57] and Wu et al (2018) [58] respectively. In their article, Wu et al (2021) [59] discussed the impact of various anesthetic techniques on immune function and oxidative stress in patients undergoing laparoscopic herniorrhaphy. The authors found that, in comparison to intravenous anesthesia (IA), TIVA had a lesser impact on immune function and oxidative stress in these patients.…”

“…In their article, Wu et al . (2021) [ 59 ] discussed the impact of various anesthetic techniques on immune function and oxidative stress in patients undergoing laparoscopic herniorrhaphy. The authors found that, in comparison to intravenous anesthesia (IA), TIVA had a lesser impact on immune function and oxidative stress in these patients.…”