Effects of different courses of moxibustion treatment on intestinal flora and inflammation of a rat model of knee osteoarthritis

Jia, Ye-Juan; Li, Tianyu; Han, Peng; Chen, Yu; Pan, Li-jia; Jia, Chun‐Sheng

doi:10.1016/j.joim.2022.01.004

Cited by 17 publications

(15 citation statements)

References 39 publications

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“…For instance, in the no stress animals, only Akkermansia was increased in the mTBI group, whereas Prevotellaceae NK3B31 , Lactobacillus , Akkermansia , and Romboutsia were altered in the surgery animals. Our increases in Prevotellaceae NK3B31 are consistent with previous literature, showing an association between Prevotellaceae NK3B31 and the inflammatory response (Jia et al., 2022). Alterations in Romboutsia are also consistent with literature suggesting a correlation with proinflammatory cytokines; however, we found decreases in bacterial abundance, but increases were observed in ulcerative colitis models (Wang et al., 2022; Wu et al., 2021).…”

Section: Discussionsupporting

confidence: 93%

Gut instinct: Sex differences in the gut microbiome are associated with changes in adolescent nociception following maternal separation in rats

Salberg,

Macowan,

Yamakawa

et al. 2023

Developmental Neurobiology

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Adolescent chronic pain is a growing public health epidemic. Our understanding of its etiology is limited; however, several factors can increase susceptibility, often developing in response to an acute pain trigger such as a surgical procedure or mild traumatic brain injury (mTBI), or an adverse childhood experience (ACE). Additionally, the prevalence and manifestation of chronic pain is sexually dimorphic, with double the rates in females than males. Despite this, the majority of pre‐clinical pain research focuses on males, leaving a gap in mechanistic understanding for females. Given that emerging evidence has linked the gut microbiome and the brain–gut–immune axis to various pain disorders, we aimed to investigate sex‐dependent changes in taxonomic and functional gut microbiome features following an ACE and acute injury as chronic pain triggers. Male and female Sprague Dawley rat pups were randomly assigned to either a maternal separation (MS) or no stress paradigm, then further into a sham, mTBI, or surgery condition. Chronically, the von Frey test was used to measure mechanical nociception, and fecal samples were collected for 16S rRNA sequencing. Animals in the surgery group had an increase in pain sensitivity when compared to mTBI and sham groups, and this was complemented by changes to the gut microbiome. In addition, significant sex differences were identified in gut microbiome composition, which were exacerbated in response to MS. Overall, we provide preliminary evidence for sex differences and ACE‐induced changes in bacterial composition that, when combined, may be contributing to heterogeneity in pain outcomes.

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Section: Discussionsupporting

confidence: 93%

Gut instinct: Sex differences in the gut microbiome are associated with changes in adolescent nociception following maternal separation in rats

Salberg,

Macowan,

Yamakawa

et al. 2023

Developmental Neurobiology

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“…In our study, the lactate-producing bacteria in the gut of SHRs proliferated, exceeding the levels found in normal rats, as reported by Verhaar et al [ 65 ]. The Lachnospiraceae_NK4A136_group belongs to Lachnospiraceae, which are intestinal pathogenic bacteria related to intestinal inflammation [ 66 , 67 ]. Ruminococcus_1 is also a pathogenic bacterium, and its produces inflammatory polysaccharides that may directly contribute to gut barrier function breakdown [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

Positive Effect of a Pea–Clam Two-Peptide Composite on Hypertension and Organ Protection in Spontaneously Hypertensive Rats

Sun

Wang²,

et al. 2022

Nutrients

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In the present study, we prepared pea peptides with high angiotensin-converting enzyme (ACE) inhibitory activity in vitro using an enzymatic hydrolysis of pea protein and compounded them with clam peptides to obtain a pea-clam double peptide. The effects of the two-peptide composite and pea peptides on hypertension and the damage-repair of corresponding organs were studied in spontaneously hypertensive rats (SHRs). We found that both pea peptides and the two-peptide composite significantly reduced the blood pressure upon a single or long-term intragastric administration, with the two-peptide composite being more effective. Mechanistically, we found that the two-peptide composite could regulate the renal renin-angiotensin system (RAS), rebalance gut microbial dysbiosis, decrease renal and myocardial fibrosis, and improve renal and cardiac function and vascular remodeling. Additionally, hippocampal lesions caused by hypertension were also eliminated after two-peptide composite administration. Our research provides a scientific basis for the use of this two-peptide composite as a safe antihypertension ingredient in functional foods.

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“…Specifically, the gut bacteriome of OA patients was significantly enriched in bacterial species, including Anaerostipes hadrus (GENOME147149), Prevotella sp900313215 GENOME108259), Eubacterium_E hallii E (GENOME000299), Blautia A (GENOME001004), and, in contrast, decreased in Bacteroides plebeius A GUT (GENOME239725), Roseburia inulinivorans (GENOME001770), and Prevotella copri (GENOME239747) and several subspecies of Faecalibacterium prausnitzii compared with that of HC subjects. High-abundance Eubacterium was also found in knee osteoarthritis in a rat model ( 27 ), suggesting potential involvement of this bacterium.…”

Section: Discussionmentioning

confidence: 99%

Characterizations of the Gut Bacteriome, Mycobiome, and Virome in Patients with Osteoarthritis

Chen

Zhang²,

Yao

et al. 2023

Microbiol Spectr

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Effects of different courses of moxibustion treatment on intestinal flora and inflammation of a rat model of knee osteoarthritis

Cited by 17 publications

References 39 publications

Gut instinct: Sex differences in the gut microbiome are associated with changes in adolescent nociception following maternal separation in rats

Gut instinct: Sex differences in the gut microbiome are associated with changes in adolescent nociception following maternal separation in rats

Positive Effect of a Pea–Clam Two-Peptide Composite on Hypertension and Organ Protection in Spontaneously Hypertensive Rats

Characterizations of the Gut Bacteriome, Mycobiome, and Virome in Patients with Osteoarthritis

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