Effects of Different Fat Supplements on Growth and Hepatic Lipids and Fatty Acids in Male Mink

Käkelä, Reijo; Pölönen, Ilpo; Miettinen, Maija; Asikainen, Juha

doi:10.1080/09064700152717191

Cited by 7 publications

(12 citation statements)

References 14 publications

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“…The FA profiles of the experimental diets were clearly reflected in the liver FA signatures of the voles as documented previously for other species [44,45]. The flaxseed oil-based diet contained more ALA and total n -3 PUFA with a higher n -3/ n -6 PUFA ratio than the lard diet and these differences were detectable in the liver FA profiles of the fed voles.…”

Section: Discussionsupporting

confidence: 71%

Manifestations of Fasting-Induced Fatty Liver and Rapid Recovery from Steatosis in Voles Fed Lard or Flaxseed Oil Lipids

et al. 2013

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Long-chain n-3 polyunsaturated fatty acids (PUFA) can have beneficial effects against fat deposition, cardiovascular diseases, and liver steatosis. We investigated how diets based on lard (predominantly saturated and monounsaturated fatty acids) or flaxseed oil (rich in 18:3n-3) affect liver fat-% and fatty acid profiles of tundra voles (Microtus oeconomus). We also studied potential participation of hyaluronan (HA) in the pathology of fatty liver and whether the development and recovery of fasting-induced steatosis are influenced by n-3 PUFA. The dietary fatty acid composition was manifested in the liver fatty acid signatures. Fasting for 18 h induced macrovesicular steatosis and the liver fat-% increased to 22% independent of the preceding diet. Fasting-induced steatosis did not involve inflammation or connective tissue activation indicated by the absence of both leukocyte accumulation and increased HA. Food deprivation modified the liver fatty acid signatures to resemble more closely the diets. Fasting reduced the proportions of long-chain n-3 PUFA in both dietary regimes and n-3/n-6 PUFA ratios in the lard-fed voles. Decreases in long-chain n-3 PUFA may promote lipid accumulation by modulating the expression of lipid-metabolizing genes. Dietary 18:3n-3 did not prevent the development or attenuate the manifestation of steatosis in the fasted voles or promote the recovery.

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Section: Discussionsupporting

confidence: 71%

Manifestations of Fasting-Induced Fatty Liver and Rapid Recovery from Steatosis in Voles Fed Lard or Flaxseed Oil Lipids

et al. 2013

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“…Dietary fat source also influenced the BW of the mink, as observed previously by Käkelä et al . [18]. According to our results, the control males fed the HO diet were significantly heavier than the males fed the SO or CO diets.…”

Section: Discussionsupporting

confidence: 55%

“…Within the liver, increasing long-chain n-3 PUFA may alter the balance between fatty acid oxidation and lipid secretion vs. de novo lipogenesis, and thereby reduce overall lipid accumulation [ 2 ]. This could make dietary fat an important consideration for mink as they are probably unable to sufficiently synthesize the long-chain n-3 and n-6 PUFA from their precursors [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…Fatty liver disease in mink is initially asymptomatic and develops rapidly to the severe stages, thus the focus needs to be on preventative measures rather than treatment. Studies have examined the effect of diet on hepatic lipid content under normal physiological conditions [ 18 ] and the relationship between body fat and hepatic lipid content in fasted mink [ 19 ], but neither has been investigated directly during the development of fatty liver. The aim of this study was to examine how feeding intensity (FI) and dietary fat sources varying in n-3 and n-6 PUFA affect the development of fasting-induced fatty liver in mink.…”

Section: Introductionmentioning

confidence: 99%

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High feeding intensity increases the severity of fatty liver in the American mink (Neovison vison) with potential ameliorating role for long-chain n-3 polyunsaturated fatty acids

Dick

Hurford

et al. 2014

Acta Vet Scand

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BackgroundRapid body fat mobilization, obesity, and an inadequate supply of n-3 polyunsaturated fatty acids (PUFA) have been suggested to play roles in the etiology of fatty liver in the American mink (Neovison vison). This study examined the effects of feeding intensity and dietary fat source on fatty liver induced by fasting. In a multi-factorial design, 3 different fat sources (herring oil, rich in n-3 PUFA, soya oil, rich in n-6 PUFA, and canola oil, rich in n-9 monounsaturated fatty acids) were fed to mink at a low and high feeding intensity for 10 weeks, followed by an overnight or a 5-day fasting treatment to induce fatty liver.ResultsFasting led to the development of fatty liver with increased severity in the mink fed at the high feeding intensity. The herring oil diet, high in long-chain n-3 PUFA, was found to decrease the severity of fatty liver in the mink at the high feeding intensity.ConclusionPreventing excessive weight gain and increasing dietary intake of n-3 long-chain PUFA may help prevent excessive lipid accumulation during prolonged periods of fasting or inappetence by promoting hepatic fatty acid oxidation.

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“…Since the advent of modern gas-liquid chromatography and high-resolution capillary columns, reports on detailed fatty acid compositions in various animal tissues have accumulated showing that the fatty acid composition of predator tissues are affected by dietary fatty acids (Rouvinen & Kiiskinen 1989, Käkelä & Hyvärinen 1996, Käkelä et al 2001, Dahl et al 2003, Iverson et al 2004. The fatty acid composition of storage so-called neutral lipids is normally closer to the ingested mixture of fatty acids than the composition of structural lipids.…”

Section: Introductionmentioning

confidence: 99%

Fatty acid signatures in plasma of captive herring gulls as indicators of demersal or pelagic fish diet

Käkelä

Käkelä²,

Kahle³

et al. 2005

Mar. Ecol. Prog. Ser.

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Current fishing practices provide scavenging seabirds with discarded demersal fish. In order to study the impact of fishery management measures and alterations in the availability of discards on seabird populations, accurate information on the birds' diet is essential. Studies of pellets and prey remains provide a biased picture and tend to be limited to seabird breeding seasons. Studying biochemical markers in bird tissues can complement other methods. In this study, captive herring gulls Larus argentatus were fed alternating diets of North Atlantic demersal and pelagic fish, and changes in the fatty acid signatures (FAS) of the birds' plasma were followed. The large differences in FAS of demersal and pelagic fish caused several clearly detectable differences in the plasma FAS of the gulls fed on these fish. A change from demersal to pelagic fish or vice versa could be detected in plasma FAS within 5 d of switching the diet, and transient changes in the gull's nutritional status did not disturb the use of the FAS. Relatively high levels of branched-chain 17:0, 18:1n-7 and 20:4n-6 are indicative of a diet of demersal fish, and high levels of 14:0, 22:1n-11, 20:1n-9, 18:2n-6, 18:3n-3 and 18:4n-3 occur when gulls eat pelagic fish. These reference FAS can be used to estimate the importance of demersal and pelagic fish in the recent diet of scavenging seabirds.

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Effects of Different Fat Supplements on Growth and Hepatic Lipids and Fatty Acids in Male Mink

Cited by 7 publications

References 14 publications

Manifestations of Fasting-Induced Fatty Liver and Rapid Recovery from Steatosis in Voles Fed Lard or Flaxseed Oil Lipids

Manifestations of Fasting-Induced Fatty Liver and Rapid Recovery from Steatosis in Voles Fed Lard or Flaxseed Oil Lipids

High feeding intensity increases the severity of fatty liver in the American mink (Neovison vison) with potential ameliorating role for long-chain n-3 polyunsaturated fatty acids

Fatty acid signatures in plasma of captive herring gulls as indicators of demersal or pelagic fish diet

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