Effects of Different Green Teas on Obesity and Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice

Abstract

Non-alcoholic fatty liver disease (NAFLD) and obesity are serious public health problems. Green tea is widely consumed in the world and different green teas could possess different bioactivities. In this study, the effects of 10 selected green teas on obesity and NAFLD were evaluated and compared. The mice fed with a high-fat diet were intervened with green tea extract (200 mg/kg body weight) for 15 weeks. Most of these teas were first evaluated for their effects on obesity and NAFLD. The results showed that Selenium-Enriched Chaoqing Green Tea and Jieyang Chaoqing Tea showed the most prominent inhibition of obesity and body weight gains of mice in these two tea intervention groups and model groups were 5.3, 5.5, and 13.7 g, respectively. In addition, Jieyang Chaoqing Tea, Taiping Houkui Tea, and Selenium-Enriched Chaoqing Green Tea exerted the most notable effect on NAFLD, which was attributed to decreasing body weight, and lipid content and ameliorating oxidative stress. Furthermore, 13 phytochemicals were determined in these teas by high-performance liquid chromatography and the correlation analysis found that epigallocatechin gallate, gallocatechin, and epigallocatechin might contribute to the decrease of hepatic weight, while epicatechin might reduce oxidative stress. In general, several green teas could prevent the development of obesity and NAFLD and could be developed into functional foods. This study was also helpful for the public to select appropriate tea to prevent obesity and NAFLD.

Human diet‐derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization

“…Several recent reports have given similar findings (Wu et al, 2021; D.‐D. Zhou, Mao, et al, 2022), but interestingly, EGCG was shown to ameliorate NAFLD/NASH by modulating intestinal immunity and macrophage polarization (Du et al, 2021; Huang et al, 2020).…”

“…In addition, Li and colleagues revealed that EGCG suppressed hepatic cholesterol synthesis through activation of the SIRT1/FOXO1 signaling pathway, consequently ameliorating dyslipidemia in rats (Li & Wu, 2018). Several recent reports have given similar findings (Wu et al, 2021;D.-D. Zhou, Mao, et al, 2022), but interestingly, EGCG was shown to ameliorate NAFLD/NASH by modulating intestinal immunity and macrophage polarization (Du et al, 2021;Huang et al, 2020).…”

Antiobesity effects of onion (Allium cepa) in subjects with obesity: Systematic review and meta‐analysis

“…Obesity can be prevented by regular physical activity, balanced nutrition, and the consumption of healthy foods. A number of studies have provided evidence for obesity-preventing foods, which are mostly plant-based and include garlic (Kagawa et al, 2020), ginger (Seo et al, 2021), tea (Zhou et al, 2022), and edible sprouts (Kim et al, 2022).…”

Identification and Quantification of Anthocyanin and Catechin Compounds in Purple Tea Leaves and Flakes

“…Additionally, an emerging purple tea variety derived from the same tea plant is now commercially produced as a healthy beverage. In general, tea—especially green tea—is considered a healthy beverage due to its high content of polyphenols which have demonstrated potential positive health effects via their roles as antioxidants [ 2 , 3 , 4 , 5 , 6 ], immune stimulators and anti-cancer [ 7 ], anti-obesity and anti-diabetic [ 8 , 9 , 10 ], anti-alcoholism [ 11 ], anti-hypertension [ 12 ] and anticardiovascular [ 13 ] diseases. The composition of polyphenols varies among teas and is influenced by a number of factors including tea variety, growing environment and processing method [ 14 ].…”