Effects of different growth factors and carriers on bone regeneration: a systematic review

Khojasteh, Arash; Behnia, Hossein; Naghdi, Navid; Esmaeelinejad, Mohammad; Alikhassy, Zahra; Stevens, Mark L.

doi:10.1016/j.oooo.2012.01.044

Cited by 78 publications

(73 citation statements)

References 69 publications

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“…Most common growth factors related to bone healing, osteoinduction and osteoconduction are: PDGF, BMPs [15,28,29], IGFs [28,30], TGF-β [15,28], FGF [24,29] and VEGF [15,24,29].…”

Section: Physiological Process Of Bone Regenerationmentioning

confidence: 99%

“…Bone formation can only proceed successfully if the tissue is adequately vascularized [15]; therefore, angiogenesis is a key component in bone repair. The new blood vessels carry oxygen and nutrients to the metabolically active callus, allowing gas exchange and the output of waste products and serve as a route for inflammatory cells, and cartilage and bone precursor cells [33,34], and also provide the gateway of systemically circulating factors that can modify the bone healing process [34].…”

Section: Physiological Process Of Bone Regenerationmentioning

confidence: 99%

“…PDGF-AB and PDGF-BB are variants circulating in alpha platelet granules and are released when platelets bind to the site of injury. The PDGF-BB variant has an active role in mitogenesis and chemotaxis of cells in the injured area [15] and plays a key role in bone regeneration [23]. After bone injury, PDGF is released by macrophages and platelets and acts as a potent chemo-attractant and mitogenic factor for cells of mesenchymal lineage, recruit fibroblasts, endothelial cells, osteoblasts and cells of the immune system.…”

Section: Platelet-derived Growth Factors (Pdgf)mentioning

confidence: 99%

“…VEGF is a potent angiogenic [29,43] and vasculogenic [23] factor that not only increases the differentiation and proliferation of endothelial cells but also increases the tubular formation and mobilization and recruitment of endothelial progenitor cells [34]. VEGF is increased in response to hypoxia, ischemia and during healing of bone tissue [15,34]. It has been shown that VEGF works synergistically with BMPs.…”

Section: Vascular Endothelial Growth Factor (Vegf)mentioning

confidence: 99%

“…The presence of cell populations that orchestrate the release of growth factors, the maintenance of a stable matrix and the stimulation of angiogenesis are key factors to successful regeneration of bone tissue, because they play a decisive role in the healing process [13,14]. The technologies developed recently based on tissue engineering, such as gene therapy, stem cell therapy and the application of osteoinductive growth factors, looking for the control of the dynamics of these elements to enable more predictable bone regeneration surge as a significant promise in clinical practice [15].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Regenerative Medicine: A New Paradigm in Bone Regeneration

Chaparro¹,

Linero²

2016

Advanced Techniques in Bone Regeneration

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Bone defects are the cause of functional disability and the restoration of skeletal function remains an important challenge on orthopedics, neurosurgery and oral and maxillofacial surgery. Because of the limitations of the currently used techniques for the reconstruction of bone defects and the difficulties for the implementation of new therapeutic strategies, a new paradigm in the field of reconstructive surgery has arisen, leading to tissue engineering and regenerative medicine. Mesenchymal stem cells (MSC) have emerged as a promising alternative for the treatment of bone lesions. It was postulated that the therapeutic action was the result of proliferation and differentiation of MSCs, replacing injured tissue. However, recent studies have shown that MSCs secrete a number of trophic factors that have a strong effect during repair and tissue regeneration. This represents a shift from a paradigm centered on MSC proliferation and differentiation to a new paradigm in which the MSCs exert their beneficial effect by the secretion of paracrine factors that induce endogenous repair mechanisms. This chapter will bring together basic and clinical aspects, focused on novel findings on MSC paracrine effect and the development of new therapeutic strategies based on growth factors, cytokines and signaling molecules involved in bone regeneration.

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“…Most common growth factors related to bone healing, osteoinduction and osteoconduction are: PDGF, BMPs [15,28,29], IGFs [28,30], TGF-β [15,28], FGF [24,29] and VEGF [15,24,29].…”

Section: Physiological Process Of Bone Regenerationmentioning

confidence: 99%

Section: Physiological Process Of Bone Regenerationmentioning

confidence: 99%

Section: Platelet-derived Growth Factors (Pdgf)mentioning

confidence: 99%

Section: Vascular Endothelial Growth Factor (Vegf)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Regenerative Medicine: A New Paradigm in Bone Regeneration

Chaparro¹,

Linero²

2016

Advanced Techniques in Bone Regeneration

View full text Add to dashboard Cite

show abstract

Autogenous Block Bone Graft for (Mainly) Vertical Ridge Augmentation in Implant Dentistry

2022

Essential Techniques of Alveolar Bone Augmentation in Implant Dentistry

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An NIR‐II Fluorescence/Dual Bioluminescence Multiplexed Imaging for In Vivo Visualizing the Location, Survival, and Differentiation of Transplanted Stem Cells

Huang

Shen

Wang

et al. 2018

Adv Funct Materials

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The in vivo distribution, viability, and differentiation capability of transplanted stem cells are vital for the therapeutic efficacy of stem cell-based therapy. Herein, an NIR-II fluorescence/dual bioluminescence multiplexed imaging method covering the visible and the second near-infrared window from 400 to 1700 nm is successfully developed for in vivo monitoring the location, survival, and osteogenic differentiation of transplanted human mesenchymal stem cells (hMSCs) in a calvarial defect mouse model. The exogenous Ag 2 S quantum dot-based fluorescence imaging in the second near-infrared window is applied for visualizing the long-term biodistribution of transplanted hMSCs. Endogenous red firefly luciferase (RFLuc)-based bioluminescence imaging (BLI) and the collagen type 1 promoter-driven Gaussia luciferase (GLuc)based BLI are employed to report the survival and osteogenic differentiation statuses of the transplanted hMSCs. Meanwhile, by integrating the three imaging channels, multiple dynamic biological behaviors of transplanted hMSCs and the promotion effects of immunosuppression and the bone morphogenetic protein 2 on the survival and osteogenic differentiation of transplanted hMSCs are directly observed. The novel multiplexed imaging method can greatly expand the capability for multifunctional analysis of the fates and therapeutic capabilities of the transplanted stem cells, and aid in the improvement of stem cell-based regeneration therapies and their clinical translation.

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Effects of different growth factors and carriers on bone regeneration: a systematic review

Cited by 78 publications

References 69 publications

Regenerative Medicine: A New Paradigm in Bone Regeneration

Regenerative Medicine: A New Paradigm in Bone Regeneration

Autogenous Block Bone Graft for (Mainly) Vertical Ridge Augmentation in Implant Dentistry

An NIR‐II Fluorescence/Dual Bioluminescence Multiplexed Imaging for In Vivo Visualizing the Location, Survival, and Differentiation of Transplanted Stem Cells

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