Effects of different hierarchical hybrid micro/nanostructure surfaces on implant osseointegration

Cheng, Bingkun; Niu, Qiang; Cui, Yang; Jiang, Wei; Zhao, Y Z; Kong, Liang

doi:10.1111/cid.12471

Cited by 8 publications

(5 citation statements)

References 30 publications

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“…The sample size calculation was based on a BIC results of one study that evaluated different micro/nanostructure surfaces on implant osseointegration compared with machined surfaces (Cheng et al, ). This study showed that the smallest difference between the means of the groups where there were statistically significant differences was 18.75% with a standard deviation of 4.24%, it was verified that a sample of seven animals per group/period was sufficient to apply statistical tests with an α‐type error of 0.05 and a β‐power of 0.90.…”

Section: Methodsmentioning

confidence: 99%

Analysis of osseointegration of implants with hydrophilic surfaces in grafted areas: A Preclinical study

Pinotti

Oliveira

Aroni

et al. 2018

Clinical Oral Implants Res

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Objectives:The aim of this study was to evaluate the effect of a hydrophilic surface on the osseointegration in grafted areas with deproteinized bovine bone (DBB) andwith biphasic ceramics of hydroxyapatite/β-tricalcium phosphate (HA/TCP). Material and methods:Fifty-six rats were randomly allocated to four groups with 14 animals each: DBB: DBB+Machined surface; HA/TCP: HA/TCP+Machined surface; DBB-H: DBB+Hydrophilic surface; HA/TCP-H: HA/TCP+Hydrophilic surface. The bone defects were performed at the proximal epiphysis of the tibia. Then, the defects were filled with the biomaterials. After 60 days, the implants were placed in the grafted areas. The animals were submitted to euthanasia at periods of 15 and 45 days after the implants' placement. The osseointegration was assessed by biomechanical, microtomographic, and histometric analyses. In addition, the expression of bone morphogenetic protein-2 (BMP-2), alkaline phosphatase (ALP), and osteocalcin (OCN) was evaluated by immunohistochemistry. Results: The HA/TCP-H group presented higher removal torque values and more mineralized tissue in the vicinity of the implants compared with the HA/TCP group. The DBB-H and HA/TCP-H groups presented higher values of bone-implant contact (at 15 and 45 days), of bone between the threads (45 days), and expression of BMP-2(45 days) than the DBB and HA/TCP groups. Furthermore, the DBB-H group presented a higher expression of ALP than the DBB group (15 days). Conclusion:In conclusion, implants with a hydrophilic surface improve osseointegration in grafted areas compared to implants with machined surfaces in a rat tibia model. K E Y W O R D Sbone substitutes, implants surfaces, osseointegration

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Section: Methodsmentioning

confidence: 99%

Analysis of osseointegration of implants with hydrophilic surfaces in grafted areas: A Preclinical study

Pinotti

Oliveira

Aroni

et al. 2018

Clinical Oral Implants Res

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“…In order to improve the roughness of the surface, many industrial techniques have also been developed to produce a thin coat (sol–gel deposition, sputtering coating techniques, or ion beam-assisted deposition) [17,18].…”

Section: Introductionmentioning

confidence: 99%

Effect of Different Surface Treatments on Titanium Dental Implant Micro-Morphology

et al. 2019

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Background: Titanium dental implants are today widely used with osseointegration mainly dependently on the implant surface properties. Different processing routes lead to different surface characteristics resulting, of course, in different in situ behaviors of the implants. Materials: The effect of different treatments, whether mechanical or chemical, on the surface morphology of titanium implants were investigated. To this aim, various experimental methods, including roughness analysis as well scanning electron microscope (SEM) observations, were applied. Results: The results showed that, in contrast to the mechanical treatments, the chemical ones gave rise to a more irregular surface. SEM observations suggested that where commercial pure titanium was used, the chemical treatments provided implant surfaces without contaminations. In contrast, sandblasted implants could cause potential risks of surface contamination because of the presence of blasting particles remnants. Conclusions: The examined implant surfaces showed different roughness levels in relation to the superficial treatment applied. The acid-etched surfaces were characterized by the presence of deeper valleys and higher peaks than the sandblasted surfaces. For this reason, acid-etched surfaces can be more easily damaged by the stress produced by the peri-implant bone during surgical implant placement.

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“…Andrukhov [18] reported that a moderately rough surface (Sa = 1-2 µm) had a considerable impact on osteoblast differentiation. Furthermore, hybrid micro/nanostructure implant surfaces have been reported to affect osseointegration through managing cell behaviors; micro-nano hybrid structure surfaces increased the wettability of such implants [19][20][21]. In this study, the Sa values for cpTi, CTO 700, and CTO 800 were relatively smoother than those of the prior reports (0.49 µm, 0.62 µm, and 0.87 µm, respectively).…”

Section: Discussionmentioning

confidence: 50%

Effect of Functionally-Graded Calcium Titanate Film, Prepared by Metal-Organic Chemical Vapor Deposition, on Titanium Implant

et al. 2019

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Calcium Titanate (CaTiO3) has been introduced as an attractive biomaterial for the enhancement of calcium phosphate deposition in vivo and in vitro. We hypothesized that CaTiO3 directly coated on titanium (Ti) by metal-organic chemical vapor deposition (MOCVD) could be a suitable candidate for biocompatible coatings for medical devices, particularly dental implants. To prove this hypothesis, surface characterization, cell culture, and animal study were completed in this study. The result of this study showed that CTO 800, a CaTiO3 film prepared by heating at 800 °C, had a high hydrophilic surface. Mouse bone marrow stromal ST-2 cells cultured on substrates and CTO 800 exhibited cell differentiation, represented by alkaline phosphatase activity, compared with cells cultured on non-coated Ti and CTO 700 (a CaTiO3 film prepared by heating at 700 °C). The push-in test value of CTO 800, a parameter that indicates the degree of osseointegration, was significantly higher than that of Ti. Calcium titanate coated on Ti by MOCVD has the potential to accelerate the process of osseointegration; thus, our results support the use of CaTiO3 coating for biocompatible biomaterial for medical applications, particularly dental implants.

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Effects of different hierarchical hybrid micro/nanostructure surfaces on implant osseointegration

Abstract: These results indicated that HF + MS surfaces exhibited superior material property in terms of bonding strength and favorable implant osseointegration compared to other groups.

Cited by 8 publications

References 30 publications

Analysis of osseointegration of implants with hydrophilic surfaces in grafted areas: A Preclinical study

Analysis of osseointegration of implants with hydrophilic surfaces in grafted areas: A Preclinical study

Effect of Different Surface Treatments on Titanium Dental Implant Micro-Morphology

Effect of Functionally-Graded Calcium Titanate Film, Prepared by Metal-Organic Chemical Vapor Deposition, on Titanium Implant

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