Effects of different intraabdominal pressure levels on oxidative stress markers in laparoscopic cholecystectomy

Doğan, Uğur; Habibi, Mani; Bülbüller, Nurullah; Elli̇dağ, Hamit Yaşar; Mayır, Burhan; Çakır, Tuğrul; Aslaner, Arif; Koç, Ümit; Gömceli, İsmail; Oruç, Mehmet Tahi̇r

doi:10.5152/turkjsurg.2017.3906

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…e operation in LC surgery activates the oxidative stress response and reduces the antioxidant capacity of the body. e already-existing oxidative stress can be further enhanced if patients are agitated during the postoperative awakening period [22]. e combined application of oxycodone hydrochloride injection and dexmedetomidine in anesthesia can reduce the production of oxidative products and enhance the antioxidant capacity, which can control the degree of oxidative stress [23].…”

Section: Discussionmentioning

confidence: 99%

The Value of Combined Application of Oxycodone Hydrochloride Injection and Dexmedetomidine in Anesthesia for LC for Patients with Gallbladder Lesions

Wang¹,

Xu²

2021

Journal of Healthcare Engineering

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Objective. To analyze the effect of combined application of oxycodone hydrochloride injection and dexmedetomidine in anesthesia for laparoscopic cholecystectomy (LC) for patients with gallbladder lesions. Method. 93 patients with gallbladder lesions in our hospital were divided into 2 groups by the random number table method. 46 patients in the control group applied oxycodone hydrochloride injection in anesthesia, and 47 patients in the observation group applied oxycodone hydrochloride injection combined with dexmedetomidine in anesthesia. Result. The T1 and T2 MAP levels in the observation group were lower than those in the control group ( P < 0.05 ), and the difference between T3 and the control group was not significantly significant ( P > 0.05 ). The T1 to T3 HR level in the observation group were lower than those in the control group ( P < 0.05 ). The rate of excessive sedation (10.64%) and sedation inefficiency (12.77%) in the observation group was lower than that in the control group (28.26% and 30.43%), and the rate of satisfactory sedation (76.60%) was higher than that in the control group (41.30%) ( P < 0.05 ). The postoperative awakening, tracheal tube removal, and first anal venting time were shorter in the observation group than in the control group ( P < 0.05 ). The WHO scores of incisional pain at 6, 12, 24, and 48 hours after the operation were lower in the observation group than in the control group ( P < 0.05 ). The T2 SOD level in the observation group was higher than that in the control group, and the ROS and MDA levels were lower than those in the control group ( P < 0.05 ). The incidence of side effects of anesthetic in the observation group was 17.02%, which was not statistically different from the control group of 13.04% ( P > 0.05 ). Conclusion. The combined application of oxycodone hydrochloride injection and dexmedetomidine in anesthesia for LC for patients with gallbladder lesions can achieve better sedation and analgesia effect, accelerate postoperative awakening and recovery, and control oxidative stress and fluctuations in signs, without increasing anesthesia-related side effects.

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Section: Discussionmentioning

confidence: 99%

The Value of Combined Application of Oxycodone Hydrochloride Injection and Dexmedetomidine in Anesthesia for LC for Patients with Gallbladder Lesions

Wang¹,

Xu²

2021

Journal of Healthcare Engineering

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Visualising improved peritoneal perfusion at lower intra-abdominal pressure by fluorescent imaging during laparoscopic surgery: A randomised controlled study

Albers

Polat

Loonen

et al. 2020

International Journal of Surgery

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Low intra-abdominal pressure in laparoscopic surgery: a systematic review and meta-analysis

Reijnders-Boerboom

Albers

Jacobs

et al. 2023

International Journal of Surgery

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Background: Guidelines do not provide clear recommendations with regard to the use of low intra-abdominal pressure (IAP) during laparoscopic surgery. The aim of this meta-analysis is to assess the influence of low versus standard IAP during laparoscopic surgery on the key-outcomes in perioperative medicine as defined by the StEP-COMPAC consensus group. Materials and methods: We searched the Cochrane Library, PubMed, and EMBASE for randomized controlled trials comparing low IAP (<10 mmHg) with standard IAP (10 mmHg or higher) during laparoscopic surgery without time, language, or blinding restrictions. According to the PRISMA guidelines, two review authors independently identified trials and extracted data. Risk ratio (RR), and mean difference (MD), with 95% CIs were calculated using random-effects models with RevMan5. Main outcomes were based on StEP-COMPAC recommendations, and included postoperative complications, postoperative pain, postoperative nausea and vomiting (PONV) scores, and length of hospital stay. Results: Eighty-five studies in a wide range of laparoscopic procedures (7349 patients) were included in this meta-analysis. The available evidence indicates that the use of low IAP (<10 mmHg) leads to a lower incidence of mild (Clavien–Dindo grade 1–2) postoperative complications (RR=0.68, 95% CI: 0.53–0.86), lower pain scores (MD=−0.68, 95% CI: −0.82 to 0.54) and PONV incidence (RR=0.67, 95% CI: 0.51–0.88), and a reduced length of hospital stay (MD=−0.29, 95% CI: −0.46 to 0.11). Low IAP did not increase the risk of intraoperative complications (RR=1.15, 95% CI: 0.77–1.73). Conclusions: Given the established safety and the reduced incidence of mild postoperative complications, lower pain scores, reduced incidence of PONV, and shorter length of stay, the available evidence supports a moderate to strong recommendation (1a level of evidence) in favor of low IAP during laparoscopic surgery.

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Effects of different intraabdominal pressure levels on oxidative stress markers in laparoscopic cholecystectomy

Abstract: Increased levels of oxidative stress markers were detected in patients who underwent laparoscopic cholecystectomy at a high intraabdominal pressure level.

Cited by 3 publications

References 22 publications

The Value of Combined Application of Oxycodone Hydrochloride Injection and Dexmedetomidine in Anesthesia for LC for Patients with Gallbladder Lesions

The Value of Combined Application of Oxycodone Hydrochloride Injection and Dexmedetomidine in Anesthesia for LC for Patients with Gallbladder Lesions

Visualising improved peritoneal perfusion at lower intra-abdominal pressure by fluorescent imaging during laparoscopic surgery: A randomised controlled study

Low intra-abdominal pressure in laparoscopic surgery: a systematic review and meta-analysis

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