Effects of different kinds and different doses of 5-HT3 receptor antagonists on prevention of hypotension after spinal anesthesia

Kim, H. B.; Lee, J. M.; Choi, Eun Su; Lee, S. Y.; Ahn, Wonsik

doi:10.1097/00003643-201306001-00410

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…A total of 121 studies were excluded because they were duplicates, obviously irrelevant trials, or did not meet the selection criteria of this analysis after reviewing the titles and abstracts. Subsequently, we carefully reviewed 26 potentially eligible articles, and 10 articles were excluded, 1 for conference abstract without full text, 1 for non‐English study, 2 for investigating the therapeutic effect of 5‐HT 3 RAs on established shivering, 1 for retraction article, 2 for letters to editors, 1 for lack of detailed information about methods of body temperature monitoring, 1 for with no grading or definition of perioperative shivering, and 1 for lack of the full texts despite contacting the authors . Finally, 16 studies were included in the meta‐analysis .…”

Section: Resultsmentioning

confidence: 99%

5‐HT₃Receptor Antagonists for the Prevention of Perioperative Shivering: A Meta‐Analysis

Wang

Song

Wang

et al. 2016

The Journal of Clinical Pharma

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The aim of this meta-analysis was to evaluate the preventive efficacy and safety of 5-HT receptor antagonists (5-HT RAs) on perioperative shivering. Relevant databases were searched to identify eligible randomized, controlled trials through January 2016. Primary outcome was the incidence of perioperative shivering, and secondary outcomes were the incidence of safety-related outcomes including postoperative nausea and vomiting (PONV), bradycardia, and hypotension. We calculated risk ratios (RRs) with 95% confidence intervals (CIs) for dichotomous data. Trial sequential analysis was performed to assess the risk of random errors and calculate the required information size. Sixteen studies with a total of 1126 patients were included in the meta-analysis. Compared with the control group, 5-HT RAs administered intravenously could statistically significantly reduce the incidence of perioperative shivering (RR, 0.44; 95%CI, 0.35 to 0.56; P < .00001; heterogeneity: I = 30%) as well as PONV (RR, 0.52; 95%CI, 0.28 to 0.97; P = .04; heterogeneity: I = 0%). However, they did not show superiority in lowering the rate of bradycardia (RR, 0.75; 95%CI, 0.38 to 1.49; P = 0.42; heterogeneity: I = 0%) or hypotension (RR, 0.79; 95%CI, 0.44 to 1.43; P = .44; heterogeneity: I = 24%). Trial sequential analysis of primary outcome showed that the required information size was 2634 patients and that the trial sequential monitoring boundary was crossed. Thus, more high-quality randomized, controlled trials with larger sample sizes are still required to draw a definite conclusion about the preventive efficacy of 5-HT RAs on perioperative shivering prevention in the future.

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Section: Resultsmentioning

confidence: 99%

5‐HT₃Receptor Antagonists for the Prevention of Perioperative Shivering: A Meta‐Analysis

Wang

Song

Wang

et al. 2016

The Journal of Clinical Pharma

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“…4 Hence, prophylactic blockade of these receptors will lower the incidence of hypotension and bradycardia, and ultimately lead to a decline in the requirement of the aforementioned rescue medications. 5 Ondansetron is frequently utilized in anaesthetic and surgical practice for the prevention of postoperative nausea and vomiting, as it provides antiemetic effect around 3 hours 6 , with multiple dosing often required. Its role as pre anaesthetic drug for maintenance of hemodynamic status is recently being evaluated with promising results.…”

Section: Introductionmentioning

confidence: 99%

Granisetron versus Ondansetron: Comparison of 5HT3 antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients

Wahid

Ali²,

Yasin³

et al. 2022

Pak J Med Sci

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Objectives: To evaluate and compare the Ondansetron and Granisetron in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients Methods: The comparative analytical study was conducted at Combined Military Hospital, Rawalpindi, from September to October, 2021. One hundred and twenty pregnant women undergoing cesarean section, were enrolled in the study via non probability convenience sampling, and divided into three groups containing 40 participants each based on the type of antiemetic premedication they received, if any: Group N were those not requiring antiemetic premedication, Group O consisted of those given ondansetron 4mg, and Group G had those receiving 3mg granisetron, 15 minutes prior to administration of spinal anaesthesia. Systolic blood pressures and heart rates were recorded before and at multiple intervals after spinal anaesthesia was administered. Episodes of hypotension and bradycardia were recorded. Requirement of phenylephrine and atropine as rescue drugs was recorded for each participant. Results: There was a statistically significant difference in incidence of hypotension among the three groups (p value <0.001), with both drugs being superior to the control group (p value <0.001 for both), and 3mg granisetron being superior to 4mg ondansetron (p value <0.001). As for incidence of bradycardia, ondansetron and granisetron were superior to control group (p value 0.03 and <0.001 respectively), but there was no significant difference between the two drug groups (p value 0.094). Conclusion: High dose granisetron (3mg) is superior to low dose ondansetron (4mg) in preventing hemodynamic fluctuations induced by spinal anaesthesia. doi: https://doi.org/10.12669/pjms.38.7.5585 How to cite this:Wahid M, Ali S, Yasin B, Farhat K, Noor M, Syed FT. Granisetron versus Ondansetron: Comparison of 5HT3 antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients. Pak J Med Sci. 2022;38(7):---------. doi: https://doi.org/10.12669/pjms.38.7.5585 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of different kinds and different doses of 5-HT3 receptor antagonists on prevention of hypotension after spinal anesthesia

Cited by 2 publications

References 2 publications

5‐HT₃Receptor Antagonists for the Prevention of Perioperative Shivering: A Meta‐Analysis

5‐HT₃Receptor Antagonists for the Prevention of Perioperative Shivering: A Meta‐Analysis

Granisetron versus Ondansetron: Comparison of 5HT3 antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients

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Effects of different kinds and different doses of 5-HT3 receptor antagonists on prevention of hypotension after spinal anesthesia

Cited by 2 publications

References 2 publications

5‐HT3Receptor Antagonists for the Prevention of Perioperative Shivering: A Meta‐Analysis

5‐HT3Receptor Antagonists for the Prevention of Perioperative Shivering: A Meta‐Analysis

Granisetron versus Ondansetron: Comparison of 5HT3 antagonists in preventing spinal anaesthesia induced hemodynamic instability in obstetric patients

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5‐HT₃Receptor Antagonists for the Prevention of Perioperative Shivering: A Meta‐Analysis

5‐HT₃Receptor Antagonists for the Prevention of Perioperative Shivering: A Meta‐Analysis