Effects of Different Organ Metastases on the Prognosis of Stage IV Urothelial Carcinoma of the Bladder

Liu, Liang; Yuan, Haibo; Wang, Qiang; Li, Chuangui

doi:10.1155/2022/8594022

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…Liu et al . [34 ▪ ] have confirmed that surgery of the primary site (endoscopic resection or cystectomy) is an independent protective factor and that the number of metastatic sites predicts OS, irrespectively of the type of the organs involved. Of course, the SEER data are partly lacking important clinical variables that should be controlled for (e.g.…”

Section: Role Of Primary Tumour and Metastases Treatment In Synchrono...mentioning

confidence: 55%

Definitions, outcomes and perspectives for oligometastatic bladder cancer: towards a standardized terminology

Calleris,

von Deimling,

Kesch

et al. 2024

Current Opinion in Urology

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Purpose of review Oligometastatic (om) cancer is considered as a transitional state in between locally confined disease and widespread metastases, accessible to a multimodal treatment, combining systemic and local therapy. In urothelial bladder cancer (BCa), the definitions and the approaches to this condition are poorly standardised and mainly based on retrospective data. We aim to portray the framework for uro-oncologic terminology in omBCa and go through the latest evidence and the future perspectives. Recent findings Retrospective and registry data support the potential benefits of multimodality treatment for carefully selected omBCa patients, especially following a good response to systemic treatment. In 2023, a Delphi consensus has defined omBCa, allowing maximum three metastatic lesions, theoretically amenable to radical local treatment. In de-novo omBCa, surgical treatment of primary tumour might improve overall survival (OS), according to a matched registry analysis; also, consolidative radiotherapy was associated with better OS in two recent cohorts. Furthermore, metastasis-directed therapy (MDT) has shown high local control rates and promising OS (14.9–51 months) in a meta-analysis; benefits might be more pronounced for single-site omBCa and nodal or lung lesions. Summary From a clinical perspective, in de-novo omBCa, the local treatment of primary and metastatic sites might improve disease control and survival, in selected patients; in the oligorecurrent setting, MDT achieves good local symptom control with limited side effects; in selected cases, it could convey a survival benefit, too. From a research perspective, well designed prospective evidence is eagerly awaited, based on recently adopted shared definitions for omBCa.

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Section: Role Of Primary Tumour and Metastases Treatment In Synchrono...mentioning

confidence: 55%

Definitions, outcomes and perspectives for oligometastatic bladder cancer: towards a standardized terminology

Calleris,

von Deimling,

Kesch

et al. 2024

Current Opinion in Urology

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“…Simultaneous metastases to other sites were common in UTUC patients with BM and significantly reduced their survival rates [ 7 , 29 ]. Liu et al suggested that the prognosis of stage IV metastatic uroepithelial carcinoma depends on the number of metastases from other organs, with no difference in OS compared to other metastatic sites when using bone metastasis as a reference [ 30 ]. Importantly, our findings contrast with those of Zhou et al [ 7 ], who reported that lung metastasis was identified as a risk factor for OS in UTUC patients with BM.…”

Section: Discussionmentioning

confidence: 99%

Establishment and validation of a nomogram for predicting overall survival of upper-tract urothelial carcinoma with bone metastasis: a population-based study

Hu,

Gu,

Zhang

et al. 2024

BMC Urol

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Background Bone metastasis (BM) carries a poor prognosis for patients with upper-tract urothelial carcinoma (UTUC). This study aims to identify survival predictors and develop a prognostic nomogram for overall survival (OS) in UTUC patients with BM. Methods The Surveillance, Epidemiology, and End Results database was used to select patients with UTUC between 2010 and 2019. The chi-square test was used to assess the baseline differences between the groups. Kaplan–Meier analysis was employed to assess OS. Univariate and multivariate analyses were conducted to identify prognostic factors for nomogram establishment. An independent cohort was used for external validation of the nomogram. The discrimination and calibration of the nomogram were evaluated using concordance index (C-index), area under receiver operating characteristic curve (AUC), calibration curve, and decision curve analysis (DCA). All statistical analyses were performed using SPSS 23.0 and R software 4.2.2. Results The mean OS for UTUC patients with BM was 10 months (95% CI: 8.17 to 11.84), with 6-month OS, 1-year OS, and 3-year OS rates of 41%, 21%, and 3%, respectively. Multi-organ metastases (HR = 2.21, 95% CI: 1.66 to 2.95, P < 0.001), surgery (HR = 0.72, 95% CI: 0.56 to 0.91, P = 0.007), and chemotherapy (HR = 0.37, 95% CI: 0.3 to 0.46, P < 0.001) were identified as independent prognostic factors. The C-index was 0.725 for the training cohort and 0.854 for the validation cohort, and all AUC values were > 0.679. The calibration curve and DCA curve showed the accuracy and practicality of the nomogram. Conclusions The OS of UTUC patients with BM was poor. Multi-organ metastases was a risk factor for OS, while surgery and chemotherapy were protective factors. Our nomogram was developed and validated to assist clinicians in evaluating the OS of UTUC patients with BM.

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“…A comparison of patient backgrounds showed that patients with mUTUC had higher frequency of lung metastasis than those with mUBC. Liu et al reported that the sites of metastasis in 1,035 patients with stage IV metastatic bladder cancer were lymph nodes in 25.4%, bone in 24.7%, lung in 19.4%, liver in 18.1%, and brain in 3.1% (26). Chen et al reported that the sites of metastasis in 424 patients with metastatic renal pelvic carcinoma were lymph nodes in 30.0%, bone in 36.1%, lung in 45.3%, liver in 32.3%, and brain in 2.8%, respectively (27).…”

Section: Discussionmentioning

confidence: 99%

Prognosis of Patients Receiving Chemotherapy for Metastatic Upper Tract Urothelial Carcinoma Compared With Metastatic Urinary Bladder Cancer

Adomi¹,

Fujita²,

Kita³

et al. 2023

CDP

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Background/Aim: The treatment strategy for metastatic upper tract urothelial carcinoma (mUTUC) is currently based on the evidence from metastatic urinary bladder cancer (mUBC). However, some reports have shown that the outcomes of UTUC differ from those of UBC. Therefore, we retrospectively analyzed the prognosis of patients with mUBC and mUTUC treated with first-line platinum-based chemotherapy. Patients and Methods: Patients who underwent platinum-based chemotherapy at the Kindai University Hospital and affiliated hospitals between January 2010 and December 2021 were included in the study. There were 56 patients with mUBC and 73 with mUTUC. Kaplan–Meier curves were used to estimate progression-free (PFS) and overall (OS) survival. Multivariate analyses were performed using Cox proportional hazards model to predict prognostic factors. Results: The median PFS was 4.5 and 4.0 months for the mUBC and mUTUC groups, respectively (p=0.094). The median OS was 17.0 months for both groups (p=0.821). The multivariate analysis showed no prognostic factor for PFS. The multivariate analysis for OS showed that younger age at the initiation of chemotherapy and immune checkpoint inhibitor use after first-line therapy were significantly associated with better OS. Conclusion: Platinum-based chemotherapy had a similar effect on patients with mUTUC and mUBC.

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Effects of Different Organ Metastases on the Prognosis of Stage IV Urothelial Carcinoma of the Bladder

Cited by 4 publications

References 31 publications

Definitions, outcomes and perspectives for oligometastatic bladder cancer: towards a standardized terminology

Definitions, outcomes and perspectives for oligometastatic bladder cancer: towards a standardized terminology

Establishment and validation of a nomogram for predicting overall survival of upper-tract urothelial carcinoma with bone metastasis: a population-based study

Prognosis of Patients Receiving Chemotherapy for Metastatic Upper Tract Urothelial Carcinoma Compared With Metastatic Urinary Bladder Cancer

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