Effects of different positions of intravascular stent implantation in stenosed vessels on in-stent restenosis: An experimental and numerical simulation study

He, Shi-Cheng; Liu, Wanling; Qu, Kai; Yin, Tieying; Qiu, Juhui; Li, Yan; Yuan, Kunshan; Zhang, Haijun; Wang, Guixue

doi:10.1016/j.jbiomech.2020.110089

Cited by 18 publications

(6 citation statements)

References 56 publications

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“…It has been reported that the blood ow velocity in different sections of the zebra sh arteries and veins show signi cant changes [21], and shear stress induces hematopoiesis in aorta-gonad-mesonephros (AGM)-embryo-derived cells [22]. We rst obtained confocal imaging of zebra sh arteries and blood ow and calculated the shear stress using 3D reconstruction with CFD analysis as our previous report [23].…”

Section: Hspcs Localize In the Posterior Somite With Slow Velocitymentioning

confidence: 97%

Temporal-Spatial Low Shear Stress Induces Heterogeneity of Hematopoietic Stem Cell Budding in Zebrafish

Cui

Shi

Zhang

et al. 2022

Preprint

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Hematopoietic stem/progenitor cells (HSPCs) originate from endothelial cells (ECs) localized on the ventral site of the dorsal aorta (DA), and hemodynamic parameters may suffer sharp changes in DA at HSPCs development stage for intersegmental vessel formation. However, the temporal-spatial shear stress parameters and biomechanics mechanisms of HSPC budding remain unknown. Here, we found that the hematopoietic endothelium (HE) in the aorta-gonad-mesonephros was heterogeneous; that is, HEs were mainly distributed at the ventral side of the vascular bifurcation in zebrafish embryos, which was found to show low shear stress (LSS) through numerical simulation analysis. Furthermore, HSPCs localized in the posterior somite of aorta-gonad-mesonephros with slow velocity. On the temporal scale, there was a slow velocity and LSS during HE budding from 36 hours post-fertilization and decreased shear stress with drug expanded HSPC numbers. Mechanistically, matrix metalloproteinase (MMP) expression and macrophage chemotaxis were significantly increased in HEs by RNA-seq. After treatment with an MMP13 inhibitor, HSPCs were significantly reduced in both the aorta-gonad-mesonephros and caudal hematopoietic tissue in embryos. Our results show that HSPC budding is heterogeneous, and the mechanism is that physiological LSS controls the emergence of HSPCs by promoting the accumulation of macrophages and subsequent MMP expression.

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Section: Hspcs Localize In the Posterior Somite With Slow Velocitymentioning

confidence: 97%

Temporal-Spatial Low Shear Stress Induces Heterogeneity of Hematopoietic Stem Cell Budding in Zebrafish

Cui

Shi

Zhang

et al. 2022

Preprint

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“…Previous studies have indicated that both biochemical (e.g., dyslipidemia) and geometric (e.g., arterial tortuosity, stenosis, size of stent) features can be risk factors of further development of the atherosclerotic lesion and subsequent ISR, where focal hemodynamics may play an important role in linking them to ISR. Relevant studies in coronary and carotid arteries have revealed that geometric features of the stented artery, such as the arterial diameter (4), vessel curvature (4)(5)(6), adjacent bifurcation angle (7) and the lesion length (8), as well as the size and shape of the stent (9,10), can significantly influence focal hemodynamics. On the other hand, the hemodynamic features, such as high pressure and low wall shear stress (WSS) can increase the filtration rate of low-density lipoprotein (LDL) in vascular endothelium, which can accelerate the growth of atherosclerotic plaques and increase the risk of ISR (11).…”

Section: Introductionmentioning

confidence: 99%

Effects of stent shape on focal hemodynamics in intracranial atherosclerotic stenosis: A simulation study with computational fluid dynamics modeling

Liu

et al. 2022

Front. Neurol.

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Background and aimsThe shape of a stent could influence focal hemodynamics and subsequently plaque growth or in-stent restenosis in intracranial atherosclerotic stenosis (ICAS). In this preliminary study, we aim to investigate the associations between stent shapes and focal hemodynamics in ICAS, using computational fluid dynamics (CFD) simulations with manually manipulated stents of different shapes.MethodsWe built an idealized artery model, and reconstructed four patient-specific models of ICAS. In each model, three variations of stent geometry (i.e., enlarged, inner-narrowed, and outer-narrowed) were developed. We performed static CFD simulation on the idealized model and three patient-specific models, and transient CFD simulation of three cardiac cycles on one patient-specific model. Pressure, wall shear stress (WSS), and low-density lipoprotein (LDL) filtration rate were quantified in the CFD models, and compared between models with an inner- or outer-narrowed stent vs. an enlarged stent. The absolute difference in each hemodynamic parameter was obtained by subtracting values from two models; a normalized difference (ND) was calculated as the ratio of the absolute difference and the value in the enlarged stent model, both area-averaged throughout the arterial wall.ResultsThe differences in focal pressure in models with different stent geometry were negligible (ND<1% for all cases). However, there were significant differences in the WSS and LDL filtration rate with different stent geometry, with ND >20% in a static model. Observable differences in WSS and LDL filtration rate mainly appeared in area adjacent to and immediately distal to the stent. In the transient simulation, the LDL filtration rate had milder temporal fluctuations than WSS.ConclusionsThe stent geometry might influence the focal WSS and LDL filtration rate in ICAS, with negligible effect on pressure. Future studies are warranted to verify the relevance of the changes in these hemodynamic parameters in governing plaque growth and possibly in-stent restenosis in ICAS.

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“…Over the years, this pathology has been deeply studied; however, the focus has essentially been on the carotid [9][10][11][12] and coronary arteries [13][14][15][16], since these are the most commonly affected arteries. Nevertheless, the abdominal aorta branches are also of great importance, such as the renal arteries and iliac bifurcation [5,[17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Numerical Study of the Unsteady Flow in Simplified and Realistic Iliac Bifurcation Models

Carvalho

Carneiro

Ferreira

et al. 2021

Fluids

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Cardiovascular diseases are a major cause of death and disability worldwide and they are commonly associated with the occurrence of atherosclerotic plaque deposition in the vessel walls, a process denoted as atherosclerosis. This is a chronic and progressive inflammatory disease of large-/medium-sized blood vessels that affects blood flow profiles, with the abdominal aorta and its branches being one of the locations prone to the development of this pathology, due to their curvatures and bifurcations. In this regard, the effect of flow patterns was studied and compared for both a simplified three-dimensional model of aorta bifurcation on the iliac arteries and a realistic model of iliac bifurcation, which was constructed from a computational tomography medical image. The flow patterns were analyzed in terms of velocity and wall shear stress distribution, but a special focus was given to the size and location of the recirculation zone. The simulations were performed using the Computational Fluid Dynamics software, FLUENT, taking into account the cardiac cycle profile at the infrarenal aorta. The shear stress and the velocity distribution observed for both models indicated that higher shear stress occurred along the flow divider wall (inner wall) and low shear stress occurred along the outer walls. In addition, the results demonstrated that the wall shear stress profiles were deeply affected by the transient profile of the cardiac cycle, with the deceleration phase being the most critical phase to the occurrence of backflow.

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Effects of different positions of intravascular stent implantation in stenosed vessels on in-stent restenosis: An experimental and numerical simulation study

Cited by 18 publications

References 56 publications

Temporal-Spatial Low Shear Stress Induces Heterogeneity of Hematopoietic Stem Cell Budding in Zebrafish

Temporal-Spatial Low Shear Stress Induces Heterogeneity of Hematopoietic Stem Cell Budding in Zebrafish

Effects of stent shape on focal hemodynamics in intracranial atherosclerotic stenosis: A simulation study with computational fluid dynamics modeling

Numerical Study of the Unsteady Flow in Simplified and Realistic Iliac Bifurcation Models

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