Effects of different resuscitation fluids on tissue blood flow and oxidant injury in experimental rhabdomyolysis

Özgüç, Halil; Kahveci, Nevzat; Akköse, Şule; Serdar, Zehra Aşiran; Balcı, Veysel; Ocak, Ozgür

doi:10.1097/01.ccm.0000186767.67870.8c

Cited by 12 publications

(7 citation statements)

References 47 publications

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“…Effekten av å alkalisere urin er omdiskutert (7,8,26). Behandlingen innebaerer til dels store vaeskemengder intravenøst, noe som medfører økt risiko for komplikasjoner i form av overhydrering.…”

Section: Diskusjonunclassified

Økning i antall pasienter med treningsindusert rabdomyolyse?

Aalborg

Rød-Larsen

Leiro³

et al. 2016

Tidsskriftet

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Section: Diskusjonunclassified

Økning i antall pasienter med treningsindusert rabdomyolyse?

Aalborg

Rød-Larsen

Leiro³

et al. 2016

Tidsskriftet

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“…It has also successfully demonstrated that creatinine kinase > 5000 U/L warrants treatment with a combination of renoprotective strategies, including aggressive hydration, bicarbonate, and mannitol. [28–30]…”

Section: Acute Kidney Injury In Polytrauma and Rhabdomyolysismentioning

confidence: 99%

Renal endocrine manifestations during polytrauma: A cause of concern for the anesthesiologist

Bajwa

Kulshrestha

2012

Indian J Endocr Metab

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Nowadays, an increasing number of patients get admitted with polytrauma, mainly due to road traffic accidents. These polytrauma victims may exhibit associated renal injuries, in addition to bone injuries and injuries to other visceral organs. Nevertheless, even in cases of polytrauma, renal tissue is hyperfunctional as part of the normal protective responses of the body to external insults. Both polytrauma and renal injuries exhibit widespread renal, endocrine, and metabolic responses. The situation is very challenging for the attending anesthesiologist, as he is expected to contribute immensely, not only in the resuscitation of such patients, but if required, to allow the operative procedures in case of life-threatening injuries. During administration of anesthesia, care has to be taken, not only to maintain hemodynamic stability, but equal attention has to be paid to various renal protection strategies. At the same time, various renoendocrine manifestations have to be taken into account, so that a judicious use of anesthesia drugs can be made, to minimize the renal insults.

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“…Some researchers have reported the addition of bicarbonate to resuscitation fluids to be effective at reducing the incidence of ARF. 45,46 These study designs, however, did not include a control group for resuscitation with only crystalloid solution, which calls into question whether their results were just a function of the aggressive resuscitation rather than the bicarbonate itself. In fact, 2 independent investigators have failed to demonstrate a significant difference between resuscitation with saline versus a bicarbonate solution in the prevention of rhabdomyolysis-induced renal failure.…”

Section: Treatment and Preventionmentioning

confidence: 99%

Rhabdomyolysis in the Intensive Care Unit

Shapiro

Baldea

Luchette

2011

J Intensive Care Med

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Rhabdomyolysis is a clinical syndrome defined by muscle breakdown and subsequent release of intracellular contents. There are many etiologies of rhabdomyolysis, classified here as congenital and acquired; compartment syndrome secondary to trauma with reperfusion injury is one common precipitating factor. Regardless of the underlying etiology, the pathophysiology follows a similar pathway via myocyte destruction and release of myoglobin into the systemic circulation. Rhabdomyolysis-induced renal failure is caused by the precipitation of myoglobin in the renal tubules which is enhanced under acidic conditions. A high index of clinical suspicion is required to promptly recognize rhabdomyolysis, especially in the unconscious patient. Presenting symptoms include tea-colored urine and muscle weakness or fatigue. The diagnosis is confirmed most reliably with the finding of elevated serum creatine kinase levels. Early, aggressive resuscitation with either normal saline or lactated Ringer's solution to maintain an adequate urine output is the most important intervention in preventing the development of acute renal failure. There is insufficient clinical evidence supporting the routine administration of diuretics and bicarbonate to protect against the development of acute renal failure.

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Effects of different resuscitation fluids on tissue blood flow and oxidant injury in experimental rhabdomyolysis

Cited by 12 publications

References 47 publications

Økning i antall pasienter med treningsindusert rabdomyolyse?

Økning i antall pasienter med treningsindusert rabdomyolyse?

Renal endocrine manifestations during polytrauma: A cause of concern for the anesthesiologist

Rhabdomyolysis in the Intensive Care Unit

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