Effects of different signaling pathways on odontogenic differentiation of dental pulp stem cells: a review

Abstract

Dental pulp stem cells (DPSCs) are a type of mesenchymal stem cells that can differentiate into odontoblast-like cells and protect the pulp. The differentiation of DPSCs can be influenced by biomaterials or growth factors that activate different signaling pathways in vitro or in vivo. In this review, we summarized six major pathways involved in the odontogenic differentiation of DPSCs, Wnt signaling pathways, Smad signaling pathways, MAPK signaling pathways, NF-kB signaling pathways, PI3K/AKT/mTOR signaling pathways, and Notch signaling pathways. Various factors can influence the odontogenic differentiation of DPSCs through one or more signaling pathways. By understanding the interactions between these signaling pathways, we can expand our knowledge of the mechanisms underlying the regeneration of the pulp–dentin complex.

Histopathological Evaluation of Human Placental Extract as a Direct Pulp-Capping Material in Dogs' Teeth

“…This family of growth factors had proved its essential role in dentin formation 46 and regeneration. 47 48 According to these reports, the differentiated odontoblast continues to produce dentin as a result of BMP signaling. 46 Specifically, BMP2 plays a key role as a regulator of the odontoblastic differentiation process and supports forming mineralized nodules.…”