Effects of different sugammadex doses on the train of four ratio recovery progression during rocuronium induced neuromuscular blockade in the rat phrenic nerve hemidiaphragm

Kim, Yong Beom; Choi, Jae-Moon; Chang, Young-Jin; Choi, Heungho; In, Junyong; Yang, Hong Seuk

doi:10.4097/kja.19278

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…Therefore, in this case, another type of neuromuscular blocking agent should be used. In addition, when excessive sugammadex is administered, T4 recovery is faster than expected, before T1 recovery, and the TOF ratio may increase, leading to errors in judgment [ 25 ]. From another point of view, negative pulmonary edema can also occur due to residual neuromuscular block.…”

Section: Discussionmentioning

confidence: 99%

Adverse events of sugammadex that occurred in a Korean population

et al. 2022

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Background: With increasing use, the incidence of adverse events associated with sugammadex, a neuromuscular blockade reverser, is increasing. This study aimed to identify and analyze cases of adverse events caused by sugammadex reported in Korean population.Methods: Out of a total of 12 cases detected using various keywords in the Korean Journal of Anesthesia, Anesthesia and Pain Medicine (Seoul), KoreaMed, PubMed, EMBASE, Web of Science, and The Cochrane Library-CENTRAL from 2013 to December 2020, 10 cases directly associated with sugammadex were selected.Results: Adverse events included five cases of anaphylaxis, one case of cardiac arrest, one case of profound bradycardia, one case of negative pressure pulmonary edema, and two cases of incomplete recovery. Three patients had American Society of Anesthesiologists physical status ≥ 3, two had emergency surgery, and two had a history of allergic reaction. Neuromuscular monitoring was applied in nine cases. The average dose of sugammadex was 2.87 mg/kg, and there were six cases in which one full vial was used, regardless of the state of neuromuscular recovery. Sugammadex was administered immediately after surgery in two cases, at train of four (TOF) 0 in four cases, at TOF 3 in one case, and after evaluation of the clinical signs only with no neuromuscular monitoring in one case.Conclusions: Even with neuromuscular monitoring, an excessive dose of sugammadex was observed. Given that adverse events tend to occur within 10 min of administration, continuous monitoring is important even after administration.

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Section: Discussionmentioning

confidence: 99%

Adverse events of sugammadex that occurred in a Korean population

et al. 2022

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“…The experimental procedures of the present study were approved by the Adıyaman University, Animal Experiments Local Ethics Committee with the report of ADYU-HADYEK 2019/032. In our study, 32 adult Sprague -Dawley male rats weighing 300-350 g were used (20,21). The rats were monitored daily under favorable conditions (Room temperature: 22-25 °C and humidity: 50-55%) with standard pellet diet and water ad libitum.…”

Section: Animals and Study Designmentioning

confidence: 99%

Possible effects of some anaesthetic agents in rat hepatotoxicity: Histological and biochemical study

Annaç¹,

ULUDAĞ²,

Doğan³

2022

JECM

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Selectively steroidal neuromuscular blocking agents, such as rocuronium, are required to maintain surgical procedures. It is a sugammadex γ-cyclodextrin-derived drug that encapsulates these drugs and reverses its effects. In the present study, it was aimed to investigate the effects of sugammadex rocuronium complex on liver and possible toxic effects on hepatocytes using histopathological and biochemical methods. In the current study, 32 adult Sprague - Dawley male rats were used. Four groups were designed as pure control, control group, sugammadex and sugammadex-rocunorium. Following the experimental procedures, liver tissues extracted from rats were stained after routine histological procedures. The images were taken from the sections for histopathological evaluation. For biochemical analysis, glutathione (GSH) and malondialdehyde (MDA) enzymes were analyzed in the liver tissues. In the group treated with the sugammadex-rocunorium complex, caspase-3 expressions were observed to be higher than in other groups. In addition, while the amount of GSH belonging to sugammadex and sugammadex-rocunorium groups decreased compared to the control group, an increase in MDA amount was found. Sugammadex-rocunorium can lead to oxidative stress in the hepatocytes. However, more studies are needed to reveal the toxic effects of sugammadex and sugammadex and rocunorium complex in the liver.

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Effects of different sugammadex doses on the train of four ratio recovery progression during rocuronium induced neuromuscular blockade in the rat phrenic nerve hemidiaphragm

Cited by 2 publications

References 21 publications

Adverse events of sugammadex that occurred in a Korean population

Adverse events of sugammadex that occurred in a Korean population

Possible effects of some anaesthetic agents in rat hepatotoxicity: Histological and biochemical study

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