Effects of different UV radiation on photoprotective pigments and antioxidant activity of the hot‐spring cyanobacterium <i>Leptolyngbya</i> cf. <i>fragilis</i>

Kokabi, Maryam; Yousefzadi, Morteza; Soltani, Maryam; Arman, Mitra

doi:10.1111/pre.12374

Cited by 16 publications

(10 citation statements)

References 24 publications

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“…A practical example of the use of proteins in cosmetics concerns PBSs, which are naturally present in cyanobacteria. One of cyanobacteria’s defensive mechanisms is the capacity of these macromolecules to absorb light energy without producing reactive oxygen species (ROS), which is possible due to the changes in their content and ratio in phycobilisomes [ 33 ]. PBPs are water-soluble proteins that are associated with phycobilins, and divided into three groups according to their structure and light absorption spectra: phycocyanin (PC, 610–625 nm), phycoerythrin (PE, 490–570 nm), and allophycocyanin (APC, 650–660 nm).…”

Section: Resultsmentioning

confidence: 99%

Cyanobacteria Secondary Metabolites as Biotechnological Ingredients in Natural Anti-Aging Cosmetics: Potential to Overcome Hyperpigmentation, Loss of Skin Density and UV Radiation-Deleterious Effects

et al. 2022

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The loss of density and elasticity, the appearance of wrinkles and hyperpigmentation are among the first noticeable signs of skin aging. Beyond UV radiation and oxidative stress, matrix metalloproteinases (MMPs) assume a preponderant role in the process, since their deregulation results in the degradation of most extracellular matrix components. In this survey, four cyanobacteria strains were explored for their capacity to produce secondary metabolites with biotechnological potential for use in anti-aging formulations. Leptolyngbya boryana LEGE 15486 and Cephalothrix lacustris LEGE 15493 from freshwater ecosystems, and Leptolyngbya cf. ectocarpi LEGE 11479 and Nodosilinea nodulosa LEGE 06104 from marine habitats were sequentially extracted with acetone and water, and extracts were analyzed for their toxicity in cell lines with key roles in the skin context (HaCAT, 3T3L1, and hCMEC). The non-toxic extracts were chemically characterized in terms of proteins, carotenoids, phenols, and chlorophyll a, and their anti-aging potential was explored through their ability to scavenge the physiological free radical superoxide anion radical (O2•−), to reduce the activity of the MMPs elastase and hyaluronidase, to inhibit tyrosinase and thus avoid melanin production, and to block UV-B radiation (sun protection factor, SPF). Leptolyngbya species stood out for anti-aging purposes: L. boryana LEGE 15486 presented a remarkable SPF of 19 (at 200 µg/mL), being among the best species regarding O2•− scavenging, (IC50 = 99.50 µg/mL) and also being able to inhibit tyrosinase (IC25 = 784 µg/mL), proving to be promising against UV-induced skin-aging; L. ectocarpi LEGE 11479 was more efficient in inhibiting MMPs (hyaluronidase, IC50 = 863 µg/mL; elastase, IC50 = 391 µg/mL), thus being the choice to retard dermal density loss. Principal component analysis (PCA) of the data allowed the grouping of extracts into three groups, according to their chemical composition; the correlation of carotenoids and chlorophyll a with MMPs activity (p < 0.01), O2•− scavenging with phenolic compounds (p < 0.01), and phycocyanin and allophycocyanin with SPF, pointing to these compounds in particular as responsible for UV-B blockage. This original survey explores, for the first time, the biotechnological potential of these cyanobacteria strains in the field of skin aging, demonstrating the promising, innovative, and multifactorial nature of these microorganisms.

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Section: Resultsmentioning

confidence: 99%

Cyanobacteria Secondary Metabolites as Biotechnological Ingredients in Natural Anti-Aging Cosmetics: Potential to Overcome Hyperpigmentation, Loss of Skin Density and UV Radiation-Deleterious Effects

et al. 2022

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“…Overall, the growth, survival, and production of cyanobacteria bioproducts have been shown to be affected by some abiotic factors such as different light wavelength bands (Sinha et al, 2003). Thus, there is a need for evaluating the different light wavelengths that may affect the growth and synthesis of bioactive compounds in order to commercially exploit Nostoc ellipsosporum (Kokabi et al, 2019). This type of research signifies an inexpensive alternative to enhance biomass production without increasing the nutrient supply (Johnson et al, 2014;Han et al, 2015;Khajepour et al, 2015;Gaytán-Luna et al, 2016;Crnkovic et al, 2017;Da Silva Ferreira & Sant'anna, 2017).…”

Section: Introductionmentioning

confidence: 99%

Modeling the effects of light wavelength on the growth of Nostoc ellipsosporum

Ortiz-Moreno¹,

Cárdenas-Poblador²,

Agredo³

et al. 2020

Univ. Sci.

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Mathematical models provide information about population dynamics under different conditions. In the study, four models were evaluated and employed to describe the growth kinetics of Nostoc ellipsosporum with different light wavelengths: Baranyi-Roberts, Modiﬁed Gompertz, Modiﬁed Logistic, and Richards. N. ellipsosporum was grown in BG-11 liquid medium for 9 days, using 12 hours of photoperiod and the following treatments: white light (400-800 nm), red light (650-800 nm), yellow light (550-580 nm) and blue light (460-480 nm). Each experiment was performed in triplicate. The optical density (OD) was measured on days 1, 3, 5, 7 and 9, using a spectrophotometer at 650 nm. The maximum cell growth was obtained under white light (OD650 : 0.090 ± 0.008), followed by the yellow light (OD650 :0.057 ± 0.004). Conversely, blue light showed a marked inhibitory effect on the growth of N. ellipsosporum (OD650 : 0.009 ± 0.001). The results revealed that the Baranyi-Roberts model had a better ﬁt with the experimental data from N. ellipsosporum growth in all four treatments. The ﬁndings from this modeling study could be used in several biotechnological applications that require the productionof N. ellipsosporum and its bioproducts.

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“…When it comes to UV radiation, cyanobacteria can produce UV-protective compounds such as phenolic compounds, scytonemins, mycosporine-like amino acids, or carotenoids [ 45 ]. Under UV radiation, the cell produces carotenoids due to the NPQ ability of these pigments, reducing oxidative stress and increasing the photosystem stability.…”

Section: Bioprocess Optimizationmentioning

confidence: 99%

“…Kokabi et al [ 45 ] saw that Leptolyngbya cf. fragilis doubles the content of carotenoids within 12 h of exposition to UV radiation (0.29 mg.g DW −1 ).…”

Section: Bioprocess Optimizationmentioning

confidence: 99%

Carotenoids from Cyanobacteria: Biotechnological Potential and Optimization Strategies

2021

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Carotenoids are tetraterpenoids molecules present in all photosynthetic organisms, responsible for better light-harvesting and energy dissipation in photosynthesis. In cyanobacteria, the biosynthetic pathway of carotenoids is well described, and apart from the more common compounds (e.g., β-carotene, zeaxanthin, and echinenone), specific carotenoids can also be found, such as myxoxanthophyll. Moreover, cyanobacteria have a protein complex called orange carotenoid protein (OCP) as a mechanism of photoprotection. Although cyanobacteria are not the organism of choice for the industrial production of carotenoids, the optimisation of their production and the evaluation of their bioactive capacity demonstrate that these organisms may indeed be a potential candidate for future pigment production in a more environmentally friendly and sustainable approach of biorefinery. Carotenoids-rich extracts are described as antioxidant, anti-inflammatory, and anti-tumoral agents and are proposed for feed and cosmetical industries. Thus, several strategies for the optimisation of a cyanobacteria-based bioprocess for the obtention of pigments were described. This review aims to give an overview of carotenoids from cyanobacteria not only in terms of their chemistry but also in terms of their biotechnological applicability and the advances and the challenges in the production of such compounds.

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Effects of different UV radiation on photoprotective pigments and antioxidant activity of the hot‐spring cyanobacterium Leptolyngbya cf. fragilis

Cited by 16 publications

References 24 publications

Cyanobacteria Secondary Metabolites as Biotechnological Ingredients in Natural Anti-Aging Cosmetics: Potential to Overcome Hyperpigmentation, Loss of Skin Density and UV Radiation-Deleterious Effects

Cyanobacteria Secondary Metabolites as Biotechnological Ingredients in Natural Anti-Aging Cosmetics: Potential to Overcome Hyperpigmentation, Loss of Skin Density and UV Radiation-Deleterious Effects

Modeling the effects of light wavelength on the growth of Nostoc ellipsosporum

Carotenoids from Cyanobacteria: Biotechnological Potential and Optimization Strategies

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