Effects of Differentiation-Inducing Factor-1 (DIF-1) of Dictyostelium discoideum on Bacteria, Fungi, and an Influenza Virus.

Anti-leukemic activities of Dictyostelium secondary metabolites: A novel aromatic metabolite, 4-methyl-5-n-pentylbenzene-1,3-diol, isolated from Dictyostelium mucoroides suppresses cell growth in human leukemia K562 and HL-60 cells

“…1), originally identified as a stalk-cell differentiationinducing factor of D. discoideum (Morris et al, 1987), has been shown to suppress cell growth and occasionally induce/promote cell differentiation in both cancer cells and de-differentiated normal cells (Asahi et al, 1995;Kubohara et al, 1995a,b;Kubohara, 1997;1999;Kubohara and Hosaka, 1999;Miwa et al, 2000;Takahashi-Yanaga et al, 2003;Akaishi et al, 2004;Life Sciences 80 (2006) 160 -165 www.elsevier.com/locate/lifescie Shimizu et al, 2004). In addition, DIF-1 has been shown to possess anti-influenza viral activity in vitro (Kuno et al, 2002) and to inhibit progesterone-induced meiosis in Xenopus oocytes . Then, AB0022A, a compound similar to DIF-1, was found in D. purpureum; this compound showed antibacterial activities against Gram-positive bacteria (Sawada et al, 2000).…”