Effects of digoxin on blood pressure responses to norepinephrine, angiotensin II and vasopressin in conscious rats.

Yasujima, Minoru; Abe, Keishi; Tanno, Masaya; Kohzuki, Masahiro; Kanazawa, Masayuki; Yoshida, Kazunori; Omata, Ken; Sato, Makito; Takeuchi, Kazuhisa; Hiwatari, Masao; Sato, Tokutaro; Yoshinaga, Kaoru

doi:10.1620/tjem.162.203

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…For their part, Yasujima et al . described an antihypertensive effect of digoxin that was sustained in rats for the entire experimental period of up to 6 days after intraperitoneal injection of digoxin simultaneously with norepinephrine (NE) compared with NE alone [11]. This decrease in SBP was not associated with any change in urinary sodium excretion.…”

Section: Digoxin and Blood Pressurementioning

confidence: 99%

Pressor and vascular effects of cardiac glycosides

Kirch

2001

Eur J Clin Investigation

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Background: For the past two decades, it has generally been accepted ('Blaustein hypothesis') that cardiac glycosides such as ouabain and digoxin increase the sodium and calcium content of smooth muscle cells, so inducing arterial vasoconstriction and a rise in blood pressure. Recent data from an experimental study we carried out led us to question this assumption. Design: A retrospective literature survey covering 20 years and including animal and human studies was performed. Representative results are presented. Results: Contradictory effects of cardiac glycosides on blood pressure and vasculature have been described. Increased, decreased or unaltered blood‐pressure values have been observed following administration of the glycosides ouabain, digoxin and digitoxin. Moreover, vasoconstricting as well as vasodilating effects of cardiac glycosides have been demonstrated. Several recent studies show that cardiac glycosides such as digoxin and digitoxin can lead to a reduction of at least diastolic blood pressure. Conclusion: A slight vasodilation of resistance vessels followed by a fall in diastolic blood pressure could be a contributing factor for the beneficial effects of cardiac glycosides in patients with congestive heart failure. This vasodilation may be caused by central (neurohumoral) effects of digitalis glycosides.

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Section: Digoxin and Blood Pressurementioning

confidence: 99%