The use of lasers in endodontics has revolutionized the dental field by offering a precise and less invasive option to treat pulp and periapical problems. This is why the importance of the diode laser in endodontics is recognized in order to potentiate the irrigation of the root canal system. The aim of this study was to interpret, by means of a systematic literature review, the use of the diode laser to enhance root canal irrigation in endodontics. Through a systematic review, 18 original articles related to the aforementioned topic were analyzed, which were obtained from the electronic search of the following databases: Springer, BioMed Central, Multidisciplinary Digital Publishing Institute, PubMed, Wiley Online Library. In addition. It was obtained as results that it is possible to reach areas such as lateral or accessory canals that may be inaccessible for traditional irrigation techniques, eliminating dentin debris, smear layer and other residues; however, despite its advantages it should be considered that the application of the diode laser should not replace conventional treatment, but should be considered as a possible complementary treatment. It is concluded that the application of the diode laser in endodontic therapy improves the efficiency of root canal system disinfection