Effects of diode laser irradiation and fibroblast growth factor on periodontal healing of replanted teeth after extended extra‐oral dry time

Carvalho, Erica dos Santos; Rosa, Rogério Hadid; Pereira, Flávia de Moura; Anbinder, Ana Lia; Mello, Isabel; Habitante, Sandra Márcia; Raldi, Denise Pontes

doi:10.1111/edt.12308

Cited by 11 publications

(29 citation statements)

References 29 publications

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“…Additionally, the lack of viable fibroblasts causes the periodontal healing process to fail. Therefore, the unprotected dental tissue is gradually replaced by bone (12).…”

Section: Introductionmentioning

confidence: 99%

A 12-Year Retrospective Study of Avulsion Cases in a Public Brazilian Dental Trauma Service.

et al. 2017

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This study assessed the epidemiological characteristics and management of the permanent teeth avulsion cases attended in a Brazilian dental trauma service from December 2005 to August 2016. A retrospective study was conducted of case records of 93 patients involving 139 avulsed teeth. Data included sex, age, trauma etiology, location of the accident, number and position of avulsed teeth, and presence and type of associated traumatic lesions. Management of the avulsed teeth was addressed as: time elapsed until teeth were retrieved from the accident's location; teeth's cleaning method and storage media; time elapsed until seeking treatment and replantation. The majority of the patients were children from 6-10 (31.2%) and 11-15 years old (26.9%). Male patients were more affected than female. Bicycle accident was the main etiological factor (31.2%). In 56 (60.2%) cases, traumatic lesions to neighboring teeth were present. In 55 (59.1%) cases, lesions to adjacent soft tissues were reported. In 82 (88.2%) cases, patients requested treatment at the same day of the accident. Sixty-four teeth (46.0%) were immediately retrieved and 28 (20.1%) were not found. Forty-two teeth (30.2%) were kept dry. Only one tooth (0.7%) was immediately replanted at the accident's site, while 51 teeth (36.7%) were not replanted. Numerous avulsed teeth were inappropriately managed and immediate replantation was not frequent. Public policies must be created to raise awareness towards the particularities of avulsion cases.

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“…Additionally, the lack of viable fibroblasts causes the periodontal healing process to fail. Therefore, the unprotected dental tissue is gradually replaced by bone (12).…”

Section: Introductionmentioning

confidence: 99%

A 12-Year Retrospective Study of Avulsion Cases in a Public Brazilian Dental Trauma Service.

et al. 2017

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“…No presente estudo, a irradiação das superfícies radiculares com laser diodo de alta potência (G3 e G5) diminuiu significativamente a ocorrência de reabsorções radiculares e anquilose, com resultados semelhantes aos do grupo controle positivo (G1). Estes resultados estão de acordo com os achados de Carvalho et al 14,15 , em que se verificou uma redução significativa das reabsorções radiculares externas, quando se realizou a irradiação das superfícies radiculares com laser diodo de alta potência, antes do reimplante tardio. Tais resultados poderiam ser justificados pela alteração estrutural na superfície radicular causada pela irradiação do laser de alta potência.…”

Section: Discussionunclassified

Efeitos do laser de diodo de alta potência e da fotobiomodulação em dentes de ratos reimplantados tardiamente

Pereira

Souza

Carvalho

et al. 2019

Rev. odontol. UNESP

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Resumo Introdução A busca por protocolos efetivos para reduzir a incidência de reabsorções radiculares e favorecer a reparação do ligamento periodontal perdido ainda representa um grande desafio, tendo em vista o prognóstico desfavorável dos reimplantes dentais tardios. Objetivo Avaliar, por meio da análise histológica, os efeitos do laser de alta potência e da fotobiomodulação na ocorrência de reabsorção radicular e no reparo periodontal, em dentes reimplantados tardiamente. Material e método Foram utilizados 50 incisivos centrais direitos de ratos Wistar. Após a extração, os espécimes foram divididos em cinco grupos (n = 10): G1 (controle positivo): reimplante imediato; G2 (controle negativo): reimplante tardio (RT): espécimes mantidos em ambiente seco por 60 minutos, sem tratamento adicional; G3: RT associado ao tratamento da superfície radicular com laser diodo de alta potência (810 nm, 1.5 W); G4: RT + superfícies radiculares e feridas alveolares tratadas com fotobiomodulação (laser diodo 660 nm, 30 mW e 780 nm, 40 mW, respectivamente); G5: RT + superfícies radiculares irradiadas com laser de alta e alvéolos com fotobiomodulação, nos mesmos parâmetros que G3 e G4, respectivamente. Após 60 dias, os animais foram eutanasiados. Os espécimes foram processados para análise histológica. Resultado G3 e G5 apresentaram as menores médias de scores com relação à ocorrência de reabsorções radiculares e anquilose, quando comparados a G2 e G4 (Teste Kruskall-Wallis, p<0,05). Com relação ao reparo periodontal, todos os grupos experimentais (G3, G4 e G5) apresentaram médias de escores inferiores (Teste Kruskall-Wallis, p<0,05) comparadas ao G1 e semelhantes ao G2 (Teste Kruskall-Wallis, p>0,05). Conclusão O laser de alta potência, associado ou não à fotobiomodulação, diminuiu a ocorrência das reabsorções radiculares e da anquilose, e a fotobiomodulação não favoreceu o controle das reabsorções radiculares nem o reparo periodontal.

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“…Moreover, FGF-2, -9, and -18 are involved in bone regeneration [52]. A positive effect of bFGF has been observed on the periodontal healing of replanted teeth [53]. bFGF is widely used for difficult wound healing treatment [54].…”

Section: Fibroblast Growth Factor Family and Wound Healingmentioning

confidence: 99%

Growth Factors, Reactive Oxygen Species, and Metformin—Promoters of the Wound Healing Process in Burns?

Miricescu

Bădoiu

Stănescu-Spînu

et al. 2021

IJMS

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Burns can be caused by various factors and have an increased risk of infection that can seriously delay the wound healing process. Chronic wounds caused by burns represent a major health problem. Wound healing is a complex process, orchestrated by cytokines, growth factors, prostaglandins, free radicals, clotting factors, and nitric oxide. Growth factors released during this process are involved in cell growth, proliferation, migration, and differentiation. Reactive oxygen species are released in acute and chronic burn injuries and play key roles in healing and regeneration. The main aim of this review is to present the roles of growth factors, reactive oxygen species, and metformin in the healing process of burn injuries.

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Effects of diode laser irradiation and fibroblast growth factor on periodontal healing of replanted teeth after extended extra‐oral dry time

Abstract: DL, with or without FGF, reduced the occurrence of external root resorption and ankylosis. Periodontal healing was favored and some fiber reinsertion occurred only when FGF was used.

Cited by 11 publications

References 29 publications

A 12-Year Retrospective Study of Avulsion Cases in a Public Brazilian Dental Trauma Service.

A 12-Year Retrospective Study of Avulsion Cases in a Public Brazilian Dental Trauma Service.

Efeitos do laser de diodo de alta potência e da fotobiomodulação em dentes de ratos reimplantados tardiamente

Growth Factors, Reactive Oxygen Species, and Metformin—Promoters of the Wound Healing Process in Burns?

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