Effects of dipeptidyl peptidase-4 inhibitor in insulin-resistant rats with myocardial infarction

Apaijai, Nattayaporn; Inthachai, Tharnwimol; Lekawanvijit, Suree; Chattipakorn, Nipon

doi:10.1530/joe-16-0096

Cited by 25 publications

(13 citation statements)

References 53 publications

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“…Blood was collected from the tail vein and centrifuged at 6,000 rpm for 10 min. The plasma was collected to allow the determination of plasma testosterone, insulin, glucose, triglyceride, total cholesterol, and HDL levels [16]. …”

Section: Methodsmentioning

confidence: 99%

“…Plasma HDL levels were determined using a commercial colorimetric kit (BioVision Inc., CA, USA). Plasma LDL levels were calculated using the Friedewald formula [16]. …”

Section: Methodsmentioning

confidence: 99%

“…Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were determined in conscious rats using a noninvasive volume-pressure recording tail cuff method (CODA-2; Kent Scientific, CT, USA) [16]. …”

Section: Methodsmentioning

confidence: 99%

“…Both the LF (0.2–0.6 Hz) and HF (0.6–3 Hz) bands were detected where LF represents sympathetic tone and HF represents parasympathetic tone. Therefore, an increased LF/HF ratio indicated cardiac sympathovagal imbalance [16]. …”

Section: Methodsmentioning

confidence: 99%

“…An S12 probe was placed on the chest at the parasternal short axis, and connected to the machine (GE Vivid-i; GE Healthcare, IL, USA). The M-mode echocardiogram was recorded at the papillary muscle, and the percentage of LV ejection fraction (%LVEF) was determined [16]. …”

Section: Methodsmentioning

confidence: 99%

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Testosterone Deprivation Aggravates Left-Ventricular Dysfunction in Male Obese Insulin-Resistant Rats via Impairing Cardiac Mitochondrial Function and Dynamics Proteins

et al. 2018

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Background: We have previously reported that testosterone deprivation at a very young age accelerated, but did not aggravate, left-ventricular (LV) dysfunction in obese insulin-resistant rats. However, the effects of testosterone deprivation during adulthood on LV function in obese insulin-resistant rats remains unclear. We hypothesized that testosterone deprivation aggravates LV dysfunction and cardiac autonomic imbalance via the impairment of cardiac mitochondrial function and dynamics proteins, a reduction in insulin receptor function, and an increase in apoptosis in obese insulin-resistant rats. Methods: Male rats were fed on either a normal diet (ND) or a high-fat diet (HFD) for 12 weeks. They were then subdivided into 2 groups: sham operation (NDS, HFS) and orchiectomy (NDO, HFO). Metabolic parameters, blood pressure, heart rate variability (HRV), and LV function were determined at baseline and before and after orchiectomy. Mitochondrial function and dynamics proteins, insulin signaling, and apoptosis were determined 12 weeks postoperatively. Results: HFS rats exhibited obese insulin resistance, depressed HRV, and LV dysfunction. In HFO rats, systolic blood pressure was increased with more excessive depression of HRV and increased LV dysfunction, compared with HFS rats. These adverse cardiac effects were consistent with markedly increased mitochondrial dysfunction, reduced mitochondrial complex I and III proteins, reduced mitochondrial fusion proteins, and increased apoptosis, compared with HFS rats. However, testosterone deprivation did not lead to any alteration in the insulin-resistant condition in HFO rats, compared with HFS rats. Conclusion: We concluded that testosterone deprivation during adulthood aggravated the impairment of mitochondrial function, mitochondrial respiratory complex, mitochondrial dynamics proteins, and apoptosis, leading to LV dysfunction in obese insulin-resistant rats.

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Section: Methodsmentioning

confidence: 99%

“…Plasma HDL levels were determined using a commercial colorimetric kit (BioVision Inc., CA, USA). Plasma LDL levels were calculated using the Friedewald formula [16]. …”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Testosterone Deprivation Aggravates Left-Ventricular Dysfunction in Male Obese Insulin-Resistant Rats via Impairing Cardiac Mitochondrial Function and Dynamics Proteins

et al. 2018

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Chronic treatment with prebiotics, probiotics and synbiotics attenuated cardiac dysfunction by improving cardiac mitochondrial dysfunction in male obese insulin-resistant rats

et al. 2017

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The impact of oral anti-diabetic medications on heart failure: lessons learned from preclinical studies

2018

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The prevalence of heart failure (HF) in the diabetic population has rapidly increased over the past 2 decades, triggering research about the impact of oral anti-diabetic medications on it. Unfortunately, not all success at the bench in preclinical experiments has translated to success at the bedside. On the other hand, recent promising clinical data from oral SGLT2 inhibitors mainly lack mechanistic explanation from experimental studies. Hence, it is critical to understand the lessons learned from prior translational studies to gain a better knowledge of the mechanisms of oral anti-diabetic drugs in HF. This review aims to summarize the results from preclinical studies regarding the interaction between oral anti-diabetic medications and heart failure development and/or exacerbation. Although there is a wide spectrum of controversial results, the underlying hope is that the clinical success rate will improve and the adverse events during ineffective targeted therapy will be limited.

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Effects of dipeptidyl peptidase-4 inhibitor in insulin-resistant rats with myocardial infarction

Cited by 25 publications

References 53 publications

Testosterone Deprivation Aggravates Left-Ventricular Dysfunction in Male Obese Insulin-Resistant Rats via Impairing Cardiac Mitochondrial Function and Dynamics Proteins

Testosterone Deprivation Aggravates Left-Ventricular Dysfunction in Male Obese Insulin-Resistant Rats via Impairing Cardiac Mitochondrial Function and Dynamics Proteins

Chronic treatment with prebiotics, probiotics and synbiotics attenuated cardiac dysfunction by improving cardiac mitochondrial dysfunction in male obese insulin-resistant rats

The impact of oral anti-diabetic medications on heart failure: lessons learned from preclinical studies

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