Effects of direct-fed microbials on growth performance, gut morphometry, and immune characteristics in broiler chickens

Lee, K. W.; Lee, S. H.; Lillehoj, Hyun S.; Li, G. X.; Jang, Seung I.; Babu, Uma S.; Park, M. S.; Kim, D. K.; Lillehoj, Erik P.; Neumann, Anthony P.; Rehberger, T.; Siragusa, Gregory R.

doi:10.3382/ps.2009-00418

Cited by 188 publications

(121 citation statements)

References 61 publications

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“…A reduction in intestinal colonization by pathogenic bacteria may have eliminated the need for the induction of these genes. Several studies have demonstrated the ability of probiotics to modulate the levels of several cytokines; however, discrepancies have been noted due to differences in the bacterial strains, combinations of probiotic strains, and presence or absence of a challenge [15][16][17]22]. Further supporting our findings, many reports have noted decreases in immune-related factors.…”

Section: Edens Et Al Compared the Hatchability Of Broiler Embryos Insupporting

confidence: 79%

“…Oral administration of probiotics results in enhanced heterophil oxidative burst and degranulation as well as augmented phagocytic capacity of macrophages [1,13,14]. Probiotics also influenced humoral and cell-mediated immune responses by increasing antibody production and upregulating T lymphocyte numbers and associated responses [15][16][17]. Probiotics have proven their ability to enhance the immune response by promoting the clearance of several economically important pathogens such as Eimeria spp., Salmonella spp., Escherichia coli and Clostridium perfringens, further asserting their potential use as an antibiotic alternative [6,[18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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In ovo and Dietary Supplementation of Probiotics Affects Post-Hatch Expression of Immune-Related Genes in Broiler Chicks

Pender¹,

Kim²,

Sumners³

et al. 2017

J immuno Biol

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During the first week post-hatch, the neonatal chick is immunologically vulnerable and subject to infectious threats found in the environment. Probiotics are live, non-pathogenic microorganisms known to have a positive effect on the host by improving the natural balance of gut microbiota and promoting animal health. The objective of this study was to determine the effects of administering probiotics in ovo and in the diet on broiler chick hatchability, and post-hatch immune organ weights and ileal immune-related gene expression. At embryonic day 18, 1584 eggs were injected with nothing (Dry), 1 × 10 6 , or 1 × 10 7 (P1 and P2 respectively) probiotic bacteria. The remaining 393 eggs were left non-injected to serve as a negative control. Immune organ weights and tissue samples were taken on DOH and d4, 6, 8, 14, and 20. No differences were observed for hatchability or relative bursa weights. Only on d6, the P2 birds receiving the probiotic-supplemented diet had larger spleens as a result of a 2-way interaction between in ovo treatment and post-hatch diet. Both in ovo and dietary administration of probiotics were able to modulate the expression of the immune-related genes in the ileum; however, expression patterns differed based on the gene, treatment, and time point evaluated. In conclusion, these results indicate that in ovo supplementation of this commercial probiotic product does not influence hatchability and is capable of differentially modulating expression of certain genes in the ileum. Furthermore, in ovo administration of probiotics has an effect similar to that of dietary supplementation endorsing its usage to potentially promote early colonization of beneficial bacteria to stimulate intestinal and immune system development.

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Section: Edens Et Al Compared the Hatchability Of Broiler Embryos Insupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

In ovo and Dietary Supplementation of Probiotics Affects Post-Hatch Expression of Immune-Related Genes in Broiler Chicks

Pender¹,

Kim²,

Sumners³

et al. 2017

J immuno Biol

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“…Furthermore, it has been found that spore forming probiotics can survive heat treatment (Amerah et al, 2013b) and are compatible with coccidiostats (Kampf et al, 2012). The numerically improved growth performance and feed utilisation efficiency due to DFM supplementation observed in this commercial scale study is in agreement with previous studies (Lee et al, 2010b;Amerah et al, 2013a;Sen et al, 2012). It has been reported that the use of a DFM containing Bacillus spp.…”

Section: Journal Of Applied Animal Nutritionsupporting

confidence: 92%

A direct fed microbial containing a combination of three-strain Bacillus sp. can be used as an alternative to feed antibiotic growth promoters in broiler production

Dersjant-Li¹,

Awati²,

Kromm³

et al. 2013

J. appl. anim. nutr.

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SummaryThe objective of the study was to test the effect of a direct fed microbial (DFM) on the performance of broilers compared to an antibiotic growth promoter under large scale, commercial production settings. Three dietary treatments were tested in a completely randomized design including: 1) a control (C) diet containing 500 FTU/kg phytase and a mixture of xylanase, amylase, protease ; 2) C+ a specific three-strain combination of Bacillus spp. (DFM) and 3) C+ bacitracin methylene disalicylate (BMD). Six, similar commercial broiler houses (15,300 birds per house) were used to give two replicate houses per treatment. The birds (Hubbard x Cobb500) were fed pelleted and crumbled diets ad libitum throughout the 44 day trial period. Due to the large scale, commercial nature of the trial, no significant differences were observed in production parameters among treatments, except that DFM treatment resulted in significantly lower mortality numbers in the last two days (43 to 44d) compared to the control. However, the DFM treatment group showed numerically higher live bodyweight, lower feed conversion ratio (corrected for body weight and mortality) and lower total mortality weight compared to either the control or BMD groups, resulting in an improved production efficiency factor. When compared to control, using DFM resulted in a gross benefit of US$ 0.06 /bird, while using BMD was not cost effective. In conclusion, DFM containing a three-strain combination of Bacillus spp. may be used as an alternative to antibiotic growth promoters, resulting in economic benefit under commercial production settings in broilers fed commercial diets.

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“…So, the improvement in the FCR in this study may be due to the increased efficiency of digestion and nutrient absorption processes by the probiotic bacteria. Other studies reported no or minimal effect of probiotics on broiler performance (Mountzouris et al, 2007;Lee et al, 2010;Zhang et al, 2011). Variations in efficacy of probiotics can be due to the difference in microbial species or micro-organism strains used, or to the additive preparation methods (Jin et al, 1998).…”

Section: Resultsmentioning

confidence: 99%

Effect ofBacillus SubtilisSpore (GalliPro^®) Nutrients Equivalency Value on Broiler Chicken Performance

Zaghari

Zahroojian

Riahi

et al. 2015

Italian Journal of Animal Science

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The experiment was conducted to evaluate the nutrients equivalency value of Bacillus subtilis spore (GalliPro ® ) for broiler chickens and its potential for decreasing feed nutrients concentration and cost. A total of 720 day old Ross 308 broiler chicks was allocated in 6 treatments (2 sexes×3 diets) with 6 replication for 7 weeks. Dietary treatments: main treatment (MT) was routine broiler diet added 0.2 g/kg GalliPro ® (Bacillus subtilis 4×10 9 CFU/g DSM 17299) and using nutrients equivalency of GalliPro ® for feed formulation; negative control (NC) was the same as main treatment without GalliPro ® (subtracted the nutrients equivalent value of GalliPro ® ); positive control (PC) was the same as MT diet in nutrients content but without GalliPro ® . Effect of dietary treatments on body weight (BW) was not significant. However, the average BW of male and female chicks receiving negative control diet was 2.0% (68 g) lower than PC and MT groups (P>0.05). Dietary treatments had no significant effect on average daily feed intake. Feed conversion ratio of chicks receiving PC and MT diets were 2.7% better than NC chicks (P<0.01). Male chicks were superior to female in all measured traits (P<0.01). Effect of treatments on carcass characteristics was not significant. There was no interaction between factors on measured parameters. Performance of chicks receiving diet with GalliPro ® compared with PC showed that GalliPro ® liberated 0.4 crude protein from MT diet and consequently decreased the broiler feeding cost.

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Effects of direct-fed microbials on growth performance, gut morphometry, and immune characteristics in broiler chickens

Cited by 188 publications

References 61 publications

In ovo and Dietary Supplementation of Probiotics Affects Post-Hatch Expression of Immune-Related Genes in Broiler Chicks

In ovo and Dietary Supplementation of Probiotics Affects Post-Hatch Expression of Immune-Related Genes in Broiler Chicks

A direct fed microbial containing a combination of three-strain Bacillus sp. can be used as an alternative to feed antibiotic growth promoters in broiler production

Effect ofBacillus SubtilisSpore (GalliPro^®) Nutrients Equivalency Value on Broiler Chicken Performance

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Effects of direct-fed microbials on growth performance, gut morphometry, and immune characteristics in broiler chickens

Cited by 188 publications

References 61 publications

In ovo and Dietary Supplementation of Probiotics Affects Post-Hatch Expression of Immune-Related Genes in Broiler Chicks

In ovo and Dietary Supplementation of Probiotics Affects Post-Hatch Expression of Immune-Related Genes in Broiler Chicks

A direct fed microbial containing a combination of three-strain Bacillus sp. can be used as an alternative to feed antibiotic growth promoters in broiler production

Effect ofBacillus SubtilisSpore (GalliPro®) Nutrients Equivalency Value on Broiler Chicken Performance

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Product

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About

Effect ofBacillus SubtilisSpore (GalliPro^®) Nutrients Equivalency Value on Broiler Chicken Performance