Effects of Dobutamine and Terbutaline on the Secretion of Glycoproteins from the Acinar Cells of the Rat Submandibular Gland

1. Noradrenaline-mediated secretion of fluid and protein from rat submandibular glands was enhanced by vasoactive intestinal peptide (VIP) and secretin but not by peptide histidine isoleucine (PHI) or gastric inhibitory peptide (GIP). 2. The synergistic effect of the combination of VIP with noradrenaline (NA) was antagonized by pretreatment with prazosin or phentolamine but not by pretreatment with yohimbine or propranolol. 3. These results suggest that VIP and secretin but not PHI and GIP can significantly enhance the secretion of fluid and protein that is mediated by NA in rat submandibular gland and that the synergistic effect of VIP and NA involves both alpha 1-adrenergic receptors and receptors for VIP.

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Effects of vasoactive intestinal peptide and its homologues on the noradrenaline-mediated secretion of fluid and protein from the rat submandibular gland

Iwabuchi

Masuhara

1994

General Pharmacology: The Vascular System

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Interaction Between Substance P and β-Adrenergic Agonists in the Modulation of the Secretion of Fluid and Protein by the Rat Submandibular Gland

Iwabuchi

Kimura

1998

Journal of Pharmacy and Pharmacology

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The interactions between substance P and beta-adrenergic agonists such as isoprenaline, dobutamine and terbutaline in the control of the secretion of fluid and protein from the rat submandibular gland have been examined. Substance P elicited large volumes of saliva whereas isoprenaline, dobutamine and terbutaline elicited small volumes only. The secretion of fluid in response to substance P was markedly enhanced when substance P was administered in combination with isoprenaline or dobutamine but not when it was administered in combination with terbutaline. Isoprenaline elicited large amounts of protein, whereas substance P elicited small amounts. The secretion of protein in response to isoprenaline did not change when isoprenaline was administered in combination with substance P. The secretion of fluid and protein induced by substance P in combination with isoprenaline was antagonized by metoprolol and by spantide, but it was unaffected by pretreatment with ICI118551. These results suggest that in the rat submandibular gland stimulation of beta1-adrenoceptors but not of beta2-adrenoceptors potentiates the secretion of fluid that is induced by stimulation of tachykinin receptors, whereas stimulation of tachykinin receptors does not enhance the secretion of protein that is induced by stimulation of beta1-adrenoceptors.

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Effects of Dobutamine and Terbutaline on the Secretion of Glycoproteins from the Acinar Cells of the Rat Submandibular Gland

Cited by 2 publications

References 27 publications

Effects of vasoactive intestinal peptide and its homologues on the noradrenaline-mediated secretion of fluid and protein from the rat submandibular gland

Effects of vasoactive intestinal peptide and its homologues on the noradrenaline-mediated secretion of fluid and protein from the rat submandibular gland

Interaction Between Substance P and β-Adrenergic Agonists in the Modulation of the Secretion of Fluid and Protein by the Rat Submandibular Gland

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